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Peptide record

TPDB14383

HFIAP-3 (hagfishes, chordates, animals) Antibacterial Anticancer Antifungal Antiparasitic Antimicrobial Anti-Gram+ Anti-Gram- modified_plain modified
31 amino acids
Basic Information
3D PDB MODEL
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TPDB14383
HFIAP-3 (hagfishes, chordates, animals)
Antibacterial Anticancer Antifungal Antiparasitic Antimicrobial Anti-Gram+ Anti-Gram-
Anti-infective peptides Cancer-related peptides
dbAMP DRAMP Peptipedia
modified_plain
Yes
A 31-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, and Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
GWFKKAWRKVKNAGRRVLKGVGIHYGVGLIZ
Physicochemical Analysis
C160H257N49O33
DCEQMPST
G
3395.11
12.17
9
0
14
+8
1.25
-0.174
94.19
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12490
367.88
2
Residue Composition
number
2
A
3
R
1
N
0
D
0
C
0
E
0
Q
6
G
1
H
2
I
2
L
5
K
0
M
1
F
0
P
0
S
0
T
2
W
1
Y
4
V
Amino Acid Distribution
A: 2 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 6 H: 1 I: 2 L: 2 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 1 V: 4
Chemical Descriptors
31
C160H257N49O33
3395.11
12.17
+8
1.25
-0.174
Evidence Records 2 records
Evidence 1 Activity

Source & Reference

dbAMP DRAMP
Evidence 2 Activity

Target

Cutibacterium acnes

Source & Reference

DRAMP
Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M.
Hagfish intestinal antimicrobial peptides are ancient cathelicidins.
Peptides. 2003 Nov 24(11):1655-1667.

Other

Source Activity Label Source Definition
Antimicrobial Antibacterial Anti-Gram+ Anti-Gram-
DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Myxine glutinosa (Atlantic hagfish)
Function: Has antibacterial against a bank of Gram-negative and Gram-positive bacteria as well as a representative fungal species. HFIAP-1 and HFIAP-3 exhibit similar inhibitory activity.