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Peptide record

TPDB14376

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
57 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB14376
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia AFP-GFuse Antifp Antifungipept dbAMP 3.0 i2APP
standard
No
A 57-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GVIPGQKQCIALKGVCRDKLCSTLDDTIGICNEGKKCCRRWWILEPYPTPVPKGKSP
Physicochemical Analysis
C277H454N78O77S6
HMF
K
6301.49
8.87
10
5
16
+5
12.28
-0.360
78.60
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12865
204.16
15
Residue Composition
number
1
A
3
R
1
N
3
D
6
C
2
E
2
Q
6
G
0
H
5
I
4
L
7
K
0
M
0
F
6
P
2
S
3
T
2
W
1
Y
3
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 3 C: 6 E: 2 Q: 2 G: 6 H: 0 I: 5 L: 4 K: 7 M: 0 F: 0 P: 6 S: 2 T: 3 W: 2 Y: 1 V: 3
Chemical Descriptors
57
C277H454N78O77S6
6301.49
8.87
+5
12.28
-0.360
Evidence Records 22 records
Evidence 1 Activity

Activity

IC50
Antibacterial
43-49 µM

Target

P. falciparum

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against P. falciparum (IC50 43-49 uM) (ref). The recombinant peptide was active against Gram+ L. monocytogenes ATCC 221633 or 1
Evidence 2 Activity

Activity

MIC
Antibacterial
25-30 µg/mL

Target

L. monocytogenes ATCC 221633 or 19115

Source & Reference

dbAMP DRAMP

Other

nst P. falciparum (IC50 43-49 uM) (ref). The recombinant peptide was active against Gram+ L. monocytogenes ATCC 221633 or 19115 (MIC 25-30 ug/ml), B. subtilis ATCC 6633 (MIC 40 ug/ml), S. aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli
Evidence 3 Activity

Activity

MIC
Antibacterial
40 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP

Other

peptide was active against Gram+ L. monocytogenes ATCC 221633 or 19115 (MIC 25-30 ug/ml), B. subtilis ATCC 6633 (MIC 40 ug/ml), S. aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli ATCC 25922 or BNCC 125783 (MIC 10 ug/
Evidence 4 Activity

Activity

MIC
Antibacterial
45 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP

Other

nocytogenes ATCC 221633 or 19115 (MIC 25-30 ug/ml), B. subtilis ATCC 6633 (MIC 40 ug/ml), S. aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli ATCC 25922 or BNCC 125783 (MIC 10 ug/ml), E. sakazakii ATCC 29544 (MIC 15
Evidence 5 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

Escherichia coli ATCC 25922 or BNCC 125783

Source & Reference

dbAMP DRAMP

Other

ug/ml), B. subtilis ATCC 6633 (MIC 40 ug/ml), S. aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli ATCC 25922 or BNCC 125783 (MIC 10 ug/ml), E. sakazakii ATCC 29544 (MIC 15 ug/ml), and S. typhimurium ATCC 14028 (MIC 15 ug/ml). It
Evidence 6 Activity

Activity

MIC
Antibacterial
15 µg/mL

Target

E. sakazakii ATCC 29544

Source & Reference

dbAMP DRAMP

Other

aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli ATCC 25922 or BNCC 125783 (MIC 10 ug/ml), E. sakazakii ATCC 29544 (MIC 15 ug/ml), and S. typhimurium ATCC 14028 (MIC 15 ug/ml). It can rapidly kill bacteria depending on
Evidence 7 Activity

Activity

MIC
Antibacterial
15 µg/mL

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

oli ATCC 25922 or BNCC 125783 (MIC 10 ug/ml), E. sakazakii ATCC 29544 (MIC 15 ug/ml), and S. typhimurium ATCC 14028 (MIC 15 ug/ml). It can rapidly kill bacteria depending on the concentration treated. Antibiofilm:bacteri
Evidence 8 Activity

Activity

IC50
Antifungal
43-49 µM

Target

P. falciparum

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against P. falciparum (IC50 43-49 uM) (ref). The recombinant peptide was active against Gram+ L. monocytogenes ATCC 221633 or 1
Evidence 9 Activity

Activity

MIC
Antifungal
25-30 µg/mL

Target

L. monocytogenes ATCC 221633 or 19115

Source & Reference

dbAMP DRAMP Antifungipept

Other

nst P. falciparum (IC50 43-49 uM) (ref). The recombinant peptide was active against Gram+ L. monocytogenes ATCC 221633 or 19115 (MIC 25-30 ug/ml), B. subtilis ATCC 6633 (MIC 40 ug/ml), S. aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli
Evidence 10 Activity

Activity

MIC
Antifungal
40 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP Antifungipept

Other

peptide was active against Gram+ L. monocytogenes ATCC 221633 or 19115 (MIC 25-30 ug/ml), B. subtilis ATCC 6633 (MIC 40 ug/ml), S. aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli ATCC 25922 or BNCC 125783 (MIC 10 ug/
Evidence 11 Activity

Activity

MIC
Antifungal
45 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP DRAMP Antifungipept

Other

nocytogenes ATCC 221633 or 19115 (MIC 25-30 ug/ml), B. subtilis ATCC 6633 (MIC 40 ug/ml), S. aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli ATCC 25922 or BNCC 125783 (MIC 10 ug/ml), E. sakazakii ATCC 29544 (MIC 15
Evidence 12 Activity

Activity

MIC
Antifungal
10 µg/mL

Target

Escherichia coli ATCC 25922 or BNCC 125783

Source & Reference

dbAMP DRAMP Antifungipept

Other

ug/ml), B. subtilis ATCC 6633 (MIC 40 ug/ml), S. aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli ATCC 25922 or BNCC 125783 (MIC 10 ug/ml), E. sakazakii ATCC 29544 (MIC 15 ug/ml), and S. typhimurium ATCC 14028 (MIC 15 ug/ml). It
Evidence 13 Activity

Activity

MIC
Antifungal
15 µg/mL

Target

E. sakazakii ATCC 29544

Source & Reference

dbAMP DRAMP Antifungipept

Other

aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli ATCC 25922 or BNCC 125783 (MIC 10 ug/ml), E. sakazakii ATCC 29544 (MIC 15 ug/ml), and S. typhimurium ATCC 14028 (MIC 15 ug/ml). It can rapidly kill bacteria depending on
Evidence 14 Activity

Activity

MIC
Antifungal
15 µg/mL

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP Antifungipept

Other

oli ATCC 25922 or BNCC 125783 (MIC 10 ug/ml), E. sakazakii ATCC 29544 (MIC 15 ug/ml), and S. typhimurium ATCC 14028 (MIC 15 ug/ml). It can rapidly kill bacteria depending on the concentration treated. Antibiofilm:bacteri
Evidence 15 Activity

Activity

IC50
Antiparasitic
43-49 µM

Target

P. falciparum

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against P. falciparum (IC50 43-49 uM) (ref). The recombinant peptide was active against Gram+ L. monocytogenes ATCC 221633 or 1
Evidence 16 Activity

Activity

MIC
Antiparasitic
25-30 µg/mL

Target

L. monocytogenes ATCC 221633 or 19115

Source & Reference

dbAMP 3.0 DRAMP

Other

nst P. falciparum (IC50 43-49 uM) (ref). The recombinant peptide was active against Gram+ L. monocytogenes ATCC 221633 or 19115 (MIC 25-30 ug/ml), B. subtilis ATCC 6633 (MIC 40 ug/ml), S. aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli
Evidence 17 Activity

Activity

MIC
Antiparasitic
40 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP 3.0 DRAMP

Other

peptide was active against Gram+ L. monocytogenes ATCC 221633 or 19115 (MIC 25-30 ug/ml), B. subtilis ATCC 6633 (MIC 40 ug/ml), S. aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli ATCC 25922 or BNCC 125783 (MIC 10 ug/
Evidence 18 Activity

Activity

MIC
Antiparasitic
45 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP 3.0 DRAMP

Other

nocytogenes ATCC 221633 or 19115 (MIC 25-30 ug/ml), B. subtilis ATCC 6633 (MIC 40 ug/ml), S. aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli ATCC 25922 or BNCC 125783 (MIC 10 ug/ml), E. sakazakii ATCC 29544 (MIC 15
Evidence 19 Activity

Activity

MIC
Antiparasitic
10 µg/mL

Target

Escherichia coli ATCC 25922 or BNCC 125783

Source & Reference

dbAMP 3.0 DRAMP

Other

ug/ml), B. subtilis ATCC 6633 (MIC 40 ug/ml), S. aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli ATCC 25922 or BNCC 125783 (MIC 10 ug/ml), E. sakazakii ATCC 29544 (MIC 15 ug/ml), and S. typhimurium ATCC 14028 (MIC 15 ug/ml). It
Evidence 20 Activity

Activity

MIC
Antiparasitic
15 µg/mL

Target

E. sakazakii ATCC 29544

Source & Reference

dbAMP 3.0 DRAMP

Other

aureus ATCC 25923 (MIC 45 ug/ml), Gram- E. coli ATCC 25922 or BNCC 125783 (MIC 10 ug/ml), E. sakazakii ATCC 29544 (MIC 15 ug/ml), and S. typhimurium ATCC 14028 (MIC 15 ug/ml). It can rapidly kill bacteria depending on
Evidence 21 Activity

Activity

MIC
Antiparasitic
15 µg/mL

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP 3.0 DRAMP

Other

oli ATCC 25922 or BNCC 125783 (MIC 10 ug/ml), E. sakazakii ATCC 29544 (MIC 15 ug/ml), and S. typhimurium ATCC 14028 (MIC 15 ug/ml). It can rapidly kill bacteria depending on the concentration treated. Antibiofilm:bacteri
Evidence 22 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Involvement of ?-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum. | Sci Rep | 2017