TPDB

3D PDB MODEL

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TPDB ID TPDB14375

Peptide_Name

Psyle E

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.

Sequence

GVIPCGESCVFIPCISSVLGCSCKNKVCYRD

FASTA

>TPDB14375|Antibacterial;Anticancer;Antifungal;Toxicity|length=31
GVIPCGESCVFIPCISSVLGCSCKNKVCYRD

Formula C139H227N37O42S6

Absent Amino Acids AQHMTW

Common Amino Acids C

Mass 3280.91

PI 7.62

Basic Residues 3

Acidic Residues 2

Hydrophobic Residues 10

Net Charge +1

Boman Index 3.19

Hydrophobicity 0.652

Aliphatic Index 87.74

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1865

Absorbance 280nm 56.84

Polar Residues 12

number

0

A

1

R

1

N

1

D

6

C

1

E

0

Q

3

G

0

H

3

I

1

L

2

K

0

M

1

F

2

P

4

S

0

T

0

W

1

Y

4

V

Amino Acid Distribution

A: 0 R: 1 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 3 L: 1 K: 2 M: 0 F: 1 P: 2 S: 4 T: 0 W: 0 Y: 1 V: 4

Length

31

Formula

C139H227N37O42S6

Mass

3280.91

PI

7.62

Net Charge

+1

Boman Index

3.19

Hydrophobicity

0.652

C_terminal_Modification

Free

Chirality

L

Linear_or_Cyclic

Not Available

N_terminal_Modification

Free

Nature

Antibacterial

Origin

Psychotria leptothyrsa

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Anticancer assay: human lymphoma cell line U937-GTB (IC50 0.76 uM). Updated 7/2021 GW

Evidence 2 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Not Available

Cell Line Not Available

Tissue Affected Not Available

Assay & Model

Assay Not Available

Testing Time Not Available

Source & Reference

Database Source CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2010

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.

Evidence 3 Activity

Activity

Detail Source Activity Antifungal

Source & Reference

Database Source dbAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Anticancer assay: human lymphoma cell line U937-GTB (IC50 0.76 uM). Updated 7/2021 GW

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 0.76 µM

Toxicity Type Cytotoxic

Toxicity Raw

Cytotoxicity: [Ref.20575512] Cytotoxicity: the human lymphoma cell line U-937 GTB (IC50=0.76 µM).

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Nat Prod. 2010 Jul 23 73(7):1207-1213.