Back to search

Peptide record

TPDB14375

Psyle E Antibacterial Anticancer Antifungal Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB14375
Psyle E
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept
standard
No
A 31-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
GVIPCGESCVFIPCISSVLGCSCKNKVCYRD
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C139H227N37O42S6
AQHMTW
C
3280.91
7.62
3
2
10
+1
0.41
0.652
87.74
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
0.57
12
Residue Composition
number
0
A
1
R
1
N
1
D
6
C
1
E
0
Q
3
G
0
H
3
I
1
L
2
K
0
M
1
F
2
P
4
S
0
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 3 L: 1 K: 2 M: 0 F: 1 P: 2 S: 4 T: 0 W: 0 Y: 1 V: 4
Chemical Descriptors
31 reviewed residue count
C139H227N37O42S6 sequence-only estimate (linear, free termini)
3280.91 sequence-only estimate (linear, free termini)
7.62 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
0.41 sequence-only estimate (linear, free termini)
0.652 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Not Available Activity
Free Activity
Antibacterial Activity
Psychotria leptothyrsa Activity
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Anticancer assay: human lymphoma cell line U937-GTB (IC50 0.76 uM). Updated 7/2021 GW
Evidence 2 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2010

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 3 Activity

Activity

Antifungal

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Anticancer assay: human lymphoma cell line U937-GTB (IC50 0.76 uM). Updated 7/2021 GW
Evidence 4 Activity

Activity

IC50
Toxicity
0.76 µM
Cytotoxic
Cytotoxicity: [Ref.20575512] Cytotoxicity: the human lymphoma cell line U-937 GTB (IC50=0.76 µM).

Source & Reference

NA
DRAMP
J Nat Prod. 2010 Jul 23 73(7):1207-1213.