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Peptide record

TPDB14293

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
78 amino acids
Basic Information
3D PDB MODEL
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TPDB14293
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia dbACP dbAMP 3.0 AFP-GFuse Antifungipept CAFPdb
standard
No
A 78-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GLICESCRKIIQKLEDMVGPQPNEDTVTQAASRVCDKMKILRGVCKKIMRTFLRRISKDILTGKKPQAICVDIKICKE
Physicochemical Analysis
C380H664N112O109S9
HWY
K
8834.68
9.75
17
9
27
+8
25.74
-0.213
97.44
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
375
4.24
18
Residue Composition
number
3
A
6
R
1
N
5
D
6
C
4
E
4
Q
4
G
0
H
10
I
5
L
11
K
3
M
1
F
3
P
3
S
4
T
0
W
0
Y
5
V
Amino Acid Distribution
A: 3 R: 6 N: 1 D: 5 C: 6 E: 4 Q: 4 G: 4 H: 0 I: 10 L: 5 K: 11 M: 3 F: 1 P: 3 S: 3 T: 4 W: 0 Y: 0 V: 5
Chemical Descriptors
78
C380H664N112O109S9
8834.68
9.75
+8
25.74
-0.213
Evidence Records 1 records
Evidence 1 Activity

Activity

% Hemolysis
Toxicity
90 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.7737114] It exhibits no hemolytic activity at 170 µM against sheep red blood cells. | Cytotoxicity: [Ref.7737114] NK-lysin at 50µg/ml was able to give 90% lysis of 5'Cr-labelled YAC-1 cells in a medium with 2% fetal calf serum(FCS) and 75% lysis in phosphate-buffered saline(PBS), 15% lysis suspended in medium E.

Target

erythrocytes

Source & Reference

NA
DRAMP
EMBO J. 1995 Apr 18 14(8):1615-1625.##Nat Struct Biol. 1997 Oct 4(10):793-795.