Back to search

Peptide record

TPDB14292

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
56 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB14292
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia ACP740 _ACP240 AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 56-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GLGSVFGRLARILGRVIPKVAKKLGPKVAKVLPKVMKEAIPMAVEMAKSQEEQQPQ
Physicochemical Analysis
C272H471N77O71S3
NDCHTWY
K
6052.39
10.96
11
4
25
+7
17.23
-0.055
102.68
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
6
Residue Composition
number
6
A
3
R
0
N
0
D
0
C
4
E
4
Q
5
G
0
H
3
I
5
L
8
K
3
M
1
F
5
P
2
S
0
T
0
W
0
Y
7
V
Amino Acid Distribution
A: 6 R: 3 N: 0 D: 0 C: 0 E: 4 Q: 4 G: 5 H: 0 I: 3 L: 5 K: 8 M: 3 F: 1 P: 5 S: 2 T: 0 W: 0 Y: 0 V: 7
Chemical Descriptors
56
C272H471N77O71S3
6052.39
10.96
+7
17.23
-0.055
Evidence Records 9 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
the full length peptide, not determined yet. The peptide is likely to be active since the antimicrobial activity of an N-terminal segment (20 residues) has been demonstrated (see APXXX).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
the full length peptide, not determined yet. The peptide is likely to be active since the antimicrobial activity of an N-terminal segment (20 residues) has been demonstrated (see APXXX).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

the full length peptide, not determined yet. The peptide is likely to be active since the antimicrobial activity of an N-terminal segment (20 residues) has been demonstrated (see APXXX).
Evidence 4 Activity

Activity

Antiviral

Source & Reference

DRAMP

Other

the full length peptide, not determined yet. The peptide is likely to be active since the antimicrobial activity of an N-terminal segment (20 residues) has been demonstrated (see APXXX).
Evidence 5 Activity

Activity

Hemolysis
Hemolysis
40 µM
[Ref.9813247]Complete lysis in the presence of pilosulin 1 was obtained at a concentration of 40 µM with evidence of partial lysis visible down to 1.25 µM

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Arch Biochem Biophys. 2005 Feb 15 434(2):358-364.##Cytometry. 1998 Aug 1 32(4):268-273.##Arch Biochem Biophys. 2005 Feb 15 434(2):358-364.##Biochem Mol Biol Int. 1996 Aug 39(5):877-885.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 6 Activity

Activity

100% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
100% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cytotoxicity of pilosulin 1, a peptide from the venom of the jumper ant Myrmecia pilosula. | Biochim Biophys Acta | 1998
Evidence 7 Activity

Activity

50% Cell death
Toxicity
0.4 µM
Cytotoxic
50% Cell death | 0.4 | µM | target cell: EBV B-cells

Target

EBV B-cells

Source & Reference

NA
DBAASP
Cytotoxicity of pilosulin 1, a peptide from the venom of the jumper ant Myrmecia pilosula. | Biochim Biophys Acta | 1998
Evidence 8 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.9813247]Complete lysis in the presence of pilosulin 1 was obtained at a concentration of 40 µM with evidence of partial lysis visible down to 1.25 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Arch Biochem Biophys. 2005 Feb 15 434(2):358-364.##Cytometry. 1998 Aug 1 32(4):268-273.##Arch Biochem Biophys. 2005 Feb 15 434(2):358-364.##Biochem Mol Biol Int. 1996 Aug 39(5):877-885.
Evidence 9 Hemolysis

Activity

40 µM
Hemolysis
[Ref.9813247]Complete lysis in the presence of pilosulin 1 was obtained at a concentration of 40 µM with evidence of partial lysis visible down to 1.25 µM
Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Arch Biochem Biophys. 2005 Feb 15 434(2):358-364.##Cytometry. 1998 Aug 1 32(4):268-273.##Arch Biochem Biophys. 2005 Feb 15 434(2):358-364.##Biochem Mol Biol Int. 1996 Aug 39(5):877-885.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.