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Peptide record

TPDB14244

Antibacterial Antifungal standard

99 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB14244

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

dbAMP Peptipedia AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 99-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from dbAMP, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.

Sequence

GGWLDIVKAIVVPAARETIKTQEITLLDHYCTLSRSPYIKSLELHYRAEVTCPGWTIIRGRGSNHRNPTNSGKDALKDFMTQAVAAGLVTKEEAAPWLN

FASTA

>TPDB14244|Antibacterial;Antifungal|length=99
GGWLDIVKAIVVPAARETIKTQEITLLDHYCTLSRSPYIKSLELHYRAEVTCPGWTIIRGRGSNHRNPTNSGKDALKDFMTQAVAAGLVTKEEAAPWLN

Formula C488H778N138O143S3

Absent Amino Acids

Common Amino Acids A

Mass 10962.56

PI 8.87

Basic Residues 15

Acidic Residues 10

Hydrophobic Residues 40

Net Charge +2

Boman Index 19.09

Hydrophobicity -0.254

Aliphatic Index 90.71

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 21095

Absorbance 280nm 192.43

Polar Residues 25

number

Amino Acid Distribution

A: 10 R: 6 N: 4 D: 4 C: 2 E: 6 Q: 2 G: 7 H: 3 I: 7 L: 9 K: 6 M: 1 F: 1 P: 5 S: 5 T: 9 W: 3 Y: 3 V: 6

Length

Formula

C488H778N138O143S3

Mass

10962.56

8.87

Net Charge

Boman Index

19.09

Hydrophobicity

-0.254

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.66-3.32 µM

Target

Target Organism V. alginolyticus L59

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

n protein containing this peptide is active against bacteria ( Liu Y et al., 2012 ) Gram- V. alginolyticus L59 (MIC 1.66-3.32 uM), P. aeruginosa P25 (MIC 26.57-53.14 uM), Gram+ M.luteus M2 (MIC >106.28 uM), S.aureus S7

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 26.57-53.14 µM

Target

Target Organism Pseudomonas aeruginosa P25

Source & Reference

Database Source dbAMP

Other

Evidence Text

ve against bacteria ( Liu Y et al., 2012 ) Gram- V. alginolyticus L59 (MIC 1.66-3.32 uM), P. aeruginosa P25 (MIC 26.57-53.14 uM), Gram+ M.luteus M2 (MIC >106.28 uM), S.aureus S7 (MIC >106.28 uM), and fungus P. pastoris

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >106.28 µM

Target

Target Organism M.luteus M2

Source & Reference

Database Source dbAMP

Other

Evidence Text

m- V. alginolyticus L59 (MIC 1.66-3.32 uM), P. aeruginosa P25 (MIC 26.57-53.14 uM), Gram+ M.luteus M2 (MIC >106.28 uM), S.aureus S7 (MIC >106.28 uM), and fungus P. pastoris GS115 (MIC 53.14-106.28 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >106.28 µM

Target

Target Organism S.aureus S7

Source & Reference

Database Source dbAMP

Other

Evidence Text

.66-3.32 uM), P. aeruginosa P25 (MIC 26.57-53.14 uM), Gram+ M.luteus M2 (MIC >106.28 uM), S.aureus S7 (MIC >106.28 uM), and fungus P. pastoris GS115 (MIC 53.14-106.28 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 53.14-106.28 µM

Target

Target Organism P. pastoris GS115

Source & Reference

Database Source dbAMP

Other

Evidence Text

7-53.14 uM), Gram+ M.luteus M2 (MIC >106.28 uM), S.aureus S7 (MIC >106.28 uM), and fungus P. pastoris GS115 (MIC 53.14-106.28 uM).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.66-3.32 µM

Target

Target Organism V. alginolyticus L59

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 26.57-53.14 µM

Target

Target Organism Pseudomonas aeruginosa P25

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >106.28 µM

Target

Target Organism M.luteus M2

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >106.28 µM

Target

Target Organism S.aureus S7

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

.66-3.32 uM), P. aeruginosa P25 (MIC 26.57-53.14 uM), Gram+ M.luteus M2 (MIC >106.28 uM), S.aureus S7 (MIC >106.28 uM), and fungus P. pastoris GS115 (MIC 53.14-106.28 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 53.14-106.28 µM

Target

Target Organism P. pastoris GS115

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

7-53.14 uM), Gram+ M.luteus M2 (MIC >106.28 uM), S.aureus S7 (MIC >106.28 uM), and fungus P. pastoris GS115 (MIC 53.14-106.28 uM).