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Peptide record

TPDB14225

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
72 amino acids
Basic Information
3D PDB MODEL
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TPDB14225
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia Antifungipept CAFPdb dbAMP 3.0 i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 72-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GFREKHFQRFVKYAVPESTLRTVLQTVVHKVGKTQFGCPAYQGYCDDHCQDIEKKEGFCHGFKCKCGIPMGF
Physicochemical Analysis
C370H560N102O100S7
NW
GK
8261.56
8.56
15
7
23
+4
16.92
-0.460
48.61
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
58.65
19
Residue Composition
number
2
A
3
R
0
N
3
D
6
C
4
E
5
Q
8
G
4
H
2
I
2
L
8
K
1
M
7
F
3
P
1
S
4
T
0
W
3
Y
6
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 3 C: 6 E: 4 Q: 5 G: 8 H: 4 I: 2 L: 2 K: 8 M: 1 F: 7 P: 3 S: 1 T: 4 W: 0 Y: 3 V: 6
Chemical Descriptors
72
C370H560N102O100S7
8261.56
8.56
+4
16.92
-0.460
Evidence Records 5 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
10.3 14.8 %
[Ref.20045493]10.3% hemolytic activity at 10 µM, 14.8% hemolytic activity at 20 µM against mouse erythrocytes

Target

mouse erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Biochim Biophys Acta. 2010 Apr 1804(4):872-883.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
10% Hemolysis | 10 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity | Biochim Biophys Acta | 2010
Evidence 3 Activity

Activity

15% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
15% Hemolysis | 20 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity | Biochim Biophys Acta | 2010
Evidence 4 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.20045493]10.3% hemolytic activity at 10 µM, 14.8% hemolytic activity at 20 µM against mouse erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2010 Apr 1804(4):872-883.
Evidence 5 Hemolysis

Activity

10.3 14.8 %
% Hemolysis
[Ref.20045493]10.3% hemolytic activity at 10 µM, 14.8% hemolytic activity at 20 µM against mouse erythrocytes
Hemolysis

Target

mouse erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Biochim Biophys Acta. 2010 Apr 1804(4):872-883.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.