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Peptide record

TPDB14215

animals) chordates hagfishes HFIAP-1 (HFIAP-2 Antibacterial Anticancer Antifungal Antiparasitic Antimicrobial Anti-Gram+ Anti-Gram- modified_plain modified
38 amino acids
Basic Information
3D PDB MODEL
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TPDB14215
animals) chordates hagfishes HFIAP-1 (HFIAP-2
Antibacterial Anticancer Antifungal Antiparasitic Antimicrobial Anti-Gram+ Anti-Gram-
Anti-infective peptides Cancer-related peptides
dbAMP DRAMP Peptipedia CAFPdb
modified_plain
Yes
A 38-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Modified, details unspecified
Sequence
GFFKKAWRKVKHAGRRVLDTAKGVGRHYVNNWLNRYRZ
Physicochemical Analysis
C205H319N69O46
CEQIMPS
R
4486.22
12.14
13
1
15
+10
5.21
-1.005
58.95
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
13980
311.62
6
Residue Composition
number
3
A
6
R
3
N
1
D
0
C
0
E
0
Q
4
G
2
H
0
I
2
L
5
K
0
M
2
F
0
P
0
S
1
T
2
W
2
Y
4
V
Amino Acid Distribution
A: 3 R: 6 N: 3 D: 1 C: 0 E: 0 Q: 0 G: 4 H: 2 I: 0 L: 2 K: 5 M: 0 F: 2 P: 0 S: 0 T: 1 W: 2 Y: 2 V: 4
Chemical Descriptors
38
C205H319N69O46
4486.22
12.14
+10
5.21
-1.005
Evidence Records 2 records
Evidence 1 Activity

Source & Reference

dbAMP DRAMP CAFPdb
Evidence 2 Activity

Target

Cutibacterium acnes

Source & Reference

DRAMP
Uzzell T, Stolzenberg ED, Shinnar AE, Zasloff M.
Hagfish intestinal antimicrobial peptides are ancient cathelicidins.
Peptides. 2003 Nov 24(11):1655-1667.

Other

Myxine glutinosa (Atlantic hagfish)
Function: Has antibacterial against a bank of Gram-negative and Gram-positive bacteria as well as a representative fungal species. Sequence similarity: Sequences for HFIAP-1 and -2 are identical, but HFIAP-2 is brominated only at residue 7 they differ from MgCath37 by conservative replacements.