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Peptide record

TPDB14200

Antibacterial Antifungal standard
149 amino acids
Basic Information
3D PDB MODEL
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TPDB14200
Antibacterial Antifungal
Anti-infective peptides
dbAMP Peptipedia Antifungipept
standard
No
A 149-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from dbAMP, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
GEVAKKDAPSSRSSCPKGSRAYGSYCYALFSVSKNWYDADMACQKRPSGHLVSVLSGAEASFLSSMIKSSGNSGQYVWIGLHDPTLGYEPNRGGWEWSNADVMNYINWETNPSSSSGNHCGTLSRASGFLKWRENYCNLELPYVCKFKA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C722H1080N200O222S9
S
16402.26
8.27
18
12
53
+3
1.66
-0.526
55.03
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
46785
2.85
54
Residue Composition
number
11
A
6
R
10
N
5
D
6
C
7
E
2
Q
14
G
3
H
3
I
10
L
9
K
3
M
4
F
7
P
24
S
3
T
6
W
9
Y
7
V
Amino Acid Distribution
A: 11 R: 6 N: 10 D: 5 C: 6 E: 7 Q: 2 G: 14 H: 3 I: 3 L: 10 K: 9 M: 3 F: 4 P: 7 S: 24 T: 3 W: 6 Y: 9 V: 7
Chemical Descriptors
149 reviewed residue count
C722H1080N200O222S9 sequence-only estimate (linear, free termini)
16402.26 sequence-only estimate (linear, free termini)
8.27 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
1.66 sequence-only estimate (linear, free termini)
-0.526 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram-positive L. monocytogenes, L. innocua, and E. faecalis. It interacts with peptidoglycan carbohydrate. This protein is essential in keeping bacteria away from ~50 micrometer zone that separates bacteria from the small intestinal cell surface Science 2011 .
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram-positive L. monocytogenes, L. innocua, and E. faecalis. It interacts with peptidoglycan carbohydrate. This protein is essential in keeping bacteria away from ~50 micrometer zone that separates bacteria from the small intestinal cell surface Science 2011 .