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Peptide record

TPDB14186

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
62 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB14186
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP DRAMP Peptipedia ACP740 _ACP240 AFP-GFuse Antifungipept CAFPdb
standard
No
A 62-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
FSKYERQKDKRPYSERKNQYTGPQFLYPPERIPPQKVIKWNEEGLPIYEIPGEGGHAEPAAA
Physicochemical Analysis
C330H497N89O95
CM
P
7231.12
9.14
11
9
19
+1
23.41
-1.300
48.87
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
12950
179.09
14
Residue Composition
number
4
A
4
R
2
N
1
D
0
C
8
E
4
Q
5
G
1
H
4
I
2
L
6
K
0
M
2
F
9
P
2
S
1
T
1
W
5
Y
1
V
Amino Acid Distribution
A: 4 R: 4 N: 2 D: 1 C: 0 E: 8 Q: 4 G: 5 H: 1 I: 4 L: 2 K: 6 M: 0 F: 2 P: 9 S: 2 T: 1 W: 1 Y: 5 V: 1
Chemical Descriptors
62
C330H497N89O95
7231.12
9.14
+1
23.41
-1.300
Evidence Records 29 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

B. subtilis ATCC 62037

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ B. subtilis ATCC 62037 (MIC 12 ug/ml), S. aureus ATCC 15752 (MIC 16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus aureus ATCC 15752

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ B. subtilis ATCC 62037 (MIC 12 ug/ml), S. aureus ATCC 15752 (MIC 16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida
Evidence 3 Activity

Activity

MIC
Antibacterial
30 µg/mL

Target

S. mutans ATCC 25175

Source & Reference

dbAMP DRAMP

Other

against Gram+ B. subtilis ATCC 62037 (MIC 12 ug/ml), S. aureus ATCC 15752 (MIC 16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp
Evidence 4 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

Escherichia coli ATCC 27325

Source & Reference

dbAMP DRAMP

Other

2 ug/ml), S. aureus ATCC 15752 (MIC 16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C.
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

P. putida ATCC 17426

Source & Reference

dbAMP DRAMP

Other

16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C. albicons ATCC 10231 (MIC 16 ug/ml),
Evidence 6 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

p. ATCC 21074

Source & Reference

dbAMP DRAMP

Other

) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C. albicons ATCC 10231 (MIC 16 ug/ml), C. neoformans ATCC 34881 (MIC 25 ug/ml)
Evidence 7 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

C. albicons ATCC 10231

Source & Reference

dbAMP DRAMP

Other

l), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C. albicons ATCC 10231 (MIC 16 ug/ml), C. neoformans ATCC 34881 (MIC 25 ug/ml), S. cerevisiae ATCC 44774 (MIC 12 ug/ml).
Evidence 8 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

C. neoformans ATCC 34881

Source & Reference

dbAMP DRAMP

Other

, Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C. albicons ATCC 10231 (MIC 16 ug/ml), C. neoformans ATCC 34881 (MIC 25 ug/ml), S. cerevisiae ATCC 44774 (MIC 12 ug/ml).
Evidence 9 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

S. cerevisiae ATCC 44774

Source & Reference

dbAMP DRAMP

Other

and fungi C. albicons ATCC 10231 (MIC 16 ug/ml), C. neoformans ATCC 34881 (MIC 25 ug/ml), S. cerevisiae ATCC 44774 (MIC 12 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

B. subtilis ATCC 62037

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ B. subtilis ATCC 62037 (MIC 12 ug/ml), S. aureus ATCC 15752 (MIC 16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli
Evidence 11 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Staphylococcus aureus ATCC 15752

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ B. subtilis ATCC 62037 (MIC 12 ug/ml), S. aureus ATCC 15752 (MIC 16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida
Evidence 12 Activity

Activity

MIC
Antifungal
30 µg/mL

Target

S. mutans ATCC 25175

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

against Gram+ B. subtilis ATCC 62037 (MIC 12 ug/ml), S. aureus ATCC 15752 (MIC 16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp
Evidence 13 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

Escherichia coli ATCC 27325

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2 ug/ml), S. aureus ATCC 15752 (MIC 16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C.
Evidence 14 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

P. putida ATCC 17426

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C. albicons ATCC 10231 (MIC 16 ug/ml),
Evidence 15 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

p. ATCC 21074

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C. albicons ATCC 10231 (MIC 16 ug/ml), C. neoformans ATCC 34881 (MIC 25 ug/ml)
Evidence 16 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

C. albicons ATCC 10231

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

l), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C. albicons ATCC 10231 (MIC 16 ug/ml), C. neoformans ATCC 34881 (MIC 25 ug/ml), S. cerevisiae ATCC 44774 (MIC 12 ug/ml).
Evidence 17 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

C. neoformans ATCC 34881

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C. albicons ATCC 10231 (MIC 16 ug/ml), C. neoformans ATCC 34881 (MIC 25 ug/ml), S. cerevisiae ATCC 44774 (MIC 12 ug/ml).
Evidence 18 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

S. cerevisiae ATCC 44774

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

and fungi C. albicons ATCC 10231 (MIC 16 ug/ml), C. neoformans ATCC 34881 (MIC 25 ug/ml), S. cerevisiae ATCC 44774 (MIC 12 ug/ml).
Evidence 19 Activity

Activity

MIC
Antiparasitic
12 µg/mL

Target

B. subtilis ATCC 62037

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ B. subtilis ATCC 62037 (MIC 12 ug/ml), S. aureus ATCC 15752 (MIC 16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli
Evidence 20 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Staphylococcus aureus ATCC 15752

Source & Reference

DRAMP

Other

Active against Gram+ B. subtilis ATCC 62037 (MIC 12 ug/ml), S. aureus ATCC 15752 (MIC 16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida
Evidence 21 Activity

Activity

MIC
Antiparasitic
30 µg/mL

Target

S. mutans ATCC 25175

Source & Reference

DRAMP

Other

against Gram+ B. subtilis ATCC 62037 (MIC 12 ug/ml), S. aureus ATCC 15752 (MIC 16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp
Evidence 22 Activity

Activity

MIC
Antiparasitic
12 µg/mL

Target

Escherichia coli ATCC 27325

Source & Reference

DRAMP

Other

2 ug/ml), S. aureus ATCC 15752 (MIC 16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C.
Evidence 23 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

P. putida ATCC 17426

Source & Reference

DRAMP

Other

16 ug/ml), S. mutans ATCC 25175 (MIC 30 ug/ml) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C. albicons ATCC 10231 (MIC 16 ug/ml),
Evidence 24 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

p. ATCC 21074

Source & Reference

DRAMP

Other

) Gram- E. coli ATCC 27325 (MIC 12 ug/ml), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C. albicons ATCC 10231 (MIC 16 ug/ml), C. neoformans ATCC 34881 (MIC 25 ug/ml)
Evidence 25 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

C. albicons ATCC 10231

Source & Reference

DRAMP

Other

l), P. putida ATCC 17426 (MIC 16 ug/ml), Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C. albicons ATCC 10231 (MIC 16 ug/ml), C. neoformans ATCC 34881 (MIC 25 ug/ml), S. cerevisiae ATCC 44774 (MIC 12 ug/ml).
Evidence 26 Activity

Activity

MIC
Antiparasitic
25 µg/mL

Target

C. neoformans ATCC 34881

Source & Reference

DRAMP

Other

, Seratia sp. ATCC 21074 (MIC 16 ug/ml), and fungi C. albicons ATCC 10231 (MIC 16 ug/ml), C. neoformans ATCC 34881 (MIC 25 ug/ml), S. cerevisiae ATCC 44774 (MIC 12 ug/ml).
Evidence 27 Activity

Activity

MIC
Antiparasitic
12 µg/mL

Target

S. cerevisiae ATCC 44774

Source & Reference

DRAMP

Other

and fungi C. albicons ATCC 10231 (MIC 16 ug/ml), C. neoformans ATCC 34881 (MIC 25 ug/ml), S. cerevisiae ATCC 44774 (MIC 12 ug/ml).
Evidence 28 Activity

Activity

0% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization. | Biochim Biophys Acta | 1998
Evidence 29 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.9784609]0.02% hemolytic activity at 5 µg/ml, 0.06% hemolytic activity at 10 µg/ml, 0.14% hemolytic activity at 25 µg/ml, 0.19% hemolytic activity at 50 µg/ml, 0.23% hemolytic activity at 100 µg/ml against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 1998 Oct 22 1408(1):67-76.