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Peptide record

TPDB14184

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

6 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB14184

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

dbAMP Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP and Peptipedia, with an available 3D structural model.

Sequence

FRWWHR

FASTA

>TPDB14184|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=6
FRWWHR

Formula C49H62N16O7

Absent Amino Acids ANDCEQGILKMPSTYV

Common Amino Acids RW

Mass 987.13

PI 12.40

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +2

Boman Index -2.25

Hydrophobicity -1.867

Aliphatic Index 0.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 1114.34

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0

Length

Formula

C49H62N16O7

Mass

987.13

12.40

Net Charge

Boman Index

-2.25

Hydrophobicity

-1.867

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 18 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against S. aureus (IC50 18 ug/ml), S. sanguis (IC50 10 ug/ml), E. coli (IC50 13 ug/ml). Updated 7/2021 formatted 5/2025

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 10 µg/mL

Target

Target Organism S. sanguis

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against S. aureus (IC50 18 ug/ml), S. sanguis (IC50 10 ug/ml), E. coli (IC50 13 ug/ml). Updated 7/2021 formatted 5/2025

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 13 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against S. aureus (IC50 18 ug/ml), S. sanguis (IC50 10 ug/ml), E. coli (IC50 13 ug/ml). Updated 7/2021 formatted 5/2025

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 18 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against S. aureus (IC50 18 ug/ml), S. sanguis (IC50 10 ug/ml), E. coli (IC50 13 ug/ml). Updated 7/2021 formatted 5/2025

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 10 µg/mL

Target

Target Organism S. sanguis

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against S. aureus (IC50 18 ug/ml), S. sanguis (IC50 10 ug/ml), E. coli (IC50 13 ug/ml). Updated 7/2021 formatted 5/2025

Evidence 6 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 13 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against S. aureus (IC50 18 ug/ml), S. sanguis (IC50 10 ug/ml), E. coli (IC50 13 ug/ml). Updated 7/2021 formatted 5/2025

Evidence 7 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 18 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus (IC50 18 ug/ml), S. sanguis (IC50 10 ug/ml), E. coli (IC50 13 ug/ml). Updated 7/2021 formatted 5/2025

Evidence 8 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 10 µg/mL

Target

Target Organism S. sanguis

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus (IC50 18 ug/ml), S. sanguis (IC50 10 ug/ml), E. coli (IC50 13 ug/ml). Updated 7/2021 formatted 5/2025

Evidence 9 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 13 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus (IC50 18 ug/ml), S. sanguis (IC50 10 ug/ml), E. coli (IC50 13 ug/ml). Updated 7/2021 formatted 5/2025

Evidence 10 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 18 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus (IC50 18 ug/ml), S. sanguis (IC50 10 ug/ml), E. coli (IC50 13 ug/ml). Updated 7/2021 formatted 5/2025

Evidence 11 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 10 µg/mL

Target

Target Organism S. sanguis

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus (IC50 18 ug/ml), S. sanguis (IC50 10 ug/ml), E. coli (IC50 13 ug/ml). Updated 7/2021 formatted 5/2025

Evidence 12 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 13 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus (IC50 18 ug/ml), S. sanguis (IC50 10 ug/ml), E. coli (IC50 13 ug/ml). Updated 7/2021 formatted 5/2025