TPDB

3D PDB MODEL

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TPDB ID TPDB14177

Activity

Antibacterial Antifungal Antiviral

Activity_category_statistics

Anti-infective peptides

Database_Source

dbAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 73-aa standard natural multi-activity (Antibacterial, Antifungal, and Antiviral) peptide sequence curated from dbAMP, Peptipedia, and Antifungipept, with an available 3D structural model.

Sequence

FPMFKRGRCLCIGPGVKAVKVADIEKASIMYPSNNCDKIEVIITLKENKGQRCLNPKSKQARLIIKKVERKNF

FASTA

>TPDB14177|Antibacterial;Antifungal;Antiviral|length=73
FPMFKRGRCLCIGPGVKAVKVADIEKASIMYPSNNCDKIEVIITLKENKGQRCLNPKSKQARLIIKKVERKNF

Formula C368H623N107O98S6

Absent Amino Acids HW

Common Amino Acids K

Mass 8307.01

PI 10.42

Basic Residues 17

Acidic Residues 6

Hydrophobic Residues 27

Net Charge +11

Boman Index 21.30

Hydrophobicity -0.351

Aliphatic Index 89.45

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 1740

Absorbance 280nm 20.95

Polar Residues 16

number

4

A

5

R

5

N

2

D

4

C

4

E

2

Q

4

G

0

H

8

I

4

L

12

K

2

M

3

F

4

P

3

S

1

T

0

W

1

Y

5

V

Amino Acid Distribution

A: 4 R: 5 N: 5 D: 2 C: 4 E: 4 Q: 2 G: 4 H: 0 I: 8 L: 4 K: 12 M: 2 F: 3 P: 4 S: 3 T: 1 W: 0 Y: 1 V: 5

Length

73

Formula

C368H623N107O98S6

Mass

8307.01

PI

10.42

Net Charge

+11

Boman Index

21.30

Hydrophobicity

-0.351

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.5 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli (MIC 6.5 ug/ml) and L. monocytogenes (MIC 8.0 ug/ml). Antimicrobial activity was also established by ( Ya

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.0 µg/mL

Target

Target Organism L. monocytogenes

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli (MIC 6.5 ug/ml) and L. monocytogenes (MIC 8.0 ug/ml). Antimicrobial activity was also established by ( Yang et al., 2003 ). At 10 ug/ml, it ki

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.5 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli (MIC 6.5 ug/ml) and L. monocytogenes (MIC 8.0 ug/ml). Antimicrobial activity was also established by ( Ya

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.0 µg/mL

Target

Target Organism L. monocytogenes

Source & Reference

Database Source dbAMP Antifungipept

Other

Evidence Text

Active against E. coli (MIC 6.5 ug/ml) and L. monocytogenes (MIC 8.0 ug/ml). Antimicrobial activity was also established by ( Yang et al., 2003 ). At 10 ug/ml, it ki

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 6.5 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 6.5 ug/ml) and L. monocytogenes (MIC 8.0 ug/ml). Antimicrobial activity was also established by ( Ya

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8.0 µg/mL

Target

Target Organism L. monocytogenes

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli (MIC 6.5 ug/ml) and L. monocytogenes (MIC 8.0 ug/ml). Antimicrobial activity was also established by ( Yang et al., 2003 ). At 10 ug/ml, it ki