Back to search

Peptide record

TPDB14175

Antibacterial Anticancer Antifungal Antiparasitic standard
51 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB14175
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
dbAMP DRAMP Peptipedia ACP740 _ACP240 AFP-GFuse Antifungipept CAFPdb
standard
No
A 51-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
FNKLKQGSSKRTCAKCFRKIMPSVHELDERRRGANRWAAGFRKCVSSICRY
Physicochemical Analysis
C257H421N87O68S5
R
5978.01
11.09
15
3
16
+11
11.69
-0.800
49.80
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
7240
121.11
14
Residue Composition
number
4
A
8
R
2
N
1
D
4
C
2
E
1
Q
3
G
1
H
2
I
2
L
6
K
1
M
3
F
1
P
5
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 4 R: 8 N: 2 D: 1 C: 4 E: 2 Q: 1 G: 3 H: 1 I: 2 L: 2 K: 6 M: 1 F: 3 P: 1 S: 5 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
51
C257H421N87O68S5
5978.01
11.09
+11
11.69
-0.800
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.1-9.2 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Perinerin has marked activity (MIC < 15 ug/ml) against P. aeruginosa (MIC 3.1-9.2 ug/ml), B. megaterium (MIC 1.5-5 ug/ml), and A.viridans (MIC 6.2-17 ug/ml), moderate activity ag
Evidence 2 Activity

Activity

MIC
Antibacterial
1.5-5 µg/mL

Target

B. megaterium

Source & Reference

dbAMP DRAMP

Other

Perinerin has marked activity (MIC < 15 ug/ml) against P. aeruginosa (MIC 3.1-9.2 ug/ml), B. megaterium (MIC 1.5-5 ug/ml), and A.viridans (MIC 6.2-17 ug/ml), moderate activity against E. coli K-12 (MIC 12.5-25 u
Evidence 3 Activity

Activity

MIC
Antibacterial
6.2-17 µg/mL

Target

A.viridans

Source & Reference

dbAMP DRAMP

Other

15 ug/ml) against P. aeruginosa (MIC 3.1-9.2 ug/ml), B. megaterium (MIC 1.5-5 ug/ml), and A.viridans (MIC 6.2-17 ug/ml), moderate activity against E. coli K-12 (MIC 12.5-25 ug/ml), S. aureus (MIC 25-50 ug/ml),
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5-25 µg/mL

Target

Escherichia coli K-12

Source & Reference

dbAMP DRAMP

Other

egaterium (MIC 1.5-5 ug/ml), and A.viridans (MIC 6.2-17 ug/ml), moderate activity against E. coli K-12 (MIC 12.5-25 ug/ml), S. aureus (MIC 25-50 ug/ml), and M. luteus (MIC 25-50 ug/ml), and minor activity against
Evidence 5 Activity

Activity

MIC
Antibacterial
25-50 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

.viridans (MIC 6.2-17 ug/ml), moderate activity against E. coli K-12 (MIC 12.5-25 ug/ml), S. aureus (MIC 25-50 ug/ml), and M. luteus (MIC 25-50 ug/ml), and minor activity against P. vulgaris (MIC 50-100 ug/m
Evidence 6 Activity

Activity

MIC
Antibacterial
25-50 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

erate activity against E. coli K-12 (MIC 12.5-25 ug/ml), S. aureus (MIC 25-50 ug/ml), and M. luteus (MIC 25-50 ug/ml), and minor activity against P. vulgaris (MIC 50-100 ug/ml), Fungus P. heliothis was also
Evidence 7 Activity

Activity

MIC
Antibacterial
50-100 µg/mL

Target

P. vulgaris

Source & Reference

dbAMP DRAMP

Other

S. aureus (MIC 25-50 ug/ml), and M. luteus (MIC 25-50 ug/ml), and minor activity against P. vulgaris (MIC 50-100 ug/ml), Fungus P. heliothis was also killed at a MIC concentration of 25 ug/ml.
Evidence 8 Activity

Activity

MIC
Antifungal
3.1-9.2 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Perinerin has marked activity (MIC < 15 ug/ml) against P. aeruginosa (MIC 3.1-9.2 ug/ml), B. megaterium (MIC 1.5-5 ug/ml), and A.viridans (MIC 6.2-17 ug/ml), moderate activity ag
Evidence 9 Activity

Activity

MIC
Antifungal
1.5-5 µg/mL

Target

B. megaterium

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Perinerin has marked activity (MIC < 15 ug/ml) against P. aeruginosa (MIC 3.1-9.2 ug/ml), B. megaterium (MIC 1.5-5 ug/ml), and A.viridans (MIC 6.2-17 ug/ml), moderate activity against E. coli K-12 (MIC 12.5-25 u
Evidence 10 Activity

Activity

MIC
Antifungal
6.2-17 µg/mL

Target

A.viridans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

15 ug/ml) against P. aeruginosa (MIC 3.1-9.2 ug/ml), B. megaterium (MIC 1.5-5 ug/ml), and A.viridans (MIC 6.2-17 ug/ml), moderate activity against E. coli K-12 (MIC 12.5-25 ug/ml), S. aureus (MIC 25-50 ug/ml),
Evidence 11 Activity

Activity

MIC
Antifungal
12.5-25 µg/mL

Target

Escherichia coli K-12

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

egaterium (MIC 1.5-5 ug/ml), and A.viridans (MIC 6.2-17 ug/ml), moderate activity against E. coli K-12 (MIC 12.5-25 ug/ml), S. aureus (MIC 25-50 ug/ml), and M. luteus (MIC 25-50 ug/ml), and minor activity against
Evidence 12 Activity

Activity

MIC
Antifungal
25-50 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

.viridans (MIC 6.2-17 ug/ml), moderate activity against E. coli K-12 (MIC 12.5-25 ug/ml), S. aureus (MIC 25-50 ug/ml), and M. luteus (MIC 25-50 ug/ml), and minor activity against P. vulgaris (MIC 50-100 ug/m
Evidence 13 Activity

Activity

MIC
Antifungal
25-50 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

erate activity against E. coli K-12 (MIC 12.5-25 ug/ml), S. aureus (MIC 25-50 ug/ml), and M. luteus (MIC 25-50 ug/ml), and minor activity against P. vulgaris (MIC 50-100 ug/ml), Fungus P. heliothis was also
Evidence 14 Activity

Activity

MIC
Antifungal
50-100 µg/mL

Target

P. vulgaris

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. aureus (MIC 25-50 ug/ml), and M. luteus (MIC 25-50 ug/ml), and minor activity against P. vulgaris (MIC 50-100 ug/ml), Fungus P. heliothis was also killed at a MIC concentration of 25 ug/ml.
Evidence 15 Activity

Activity

MIC
Antiparasitic
3.1-9.2 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Perinerin has marked activity (MIC < 15 ug/ml) against P. aeruginosa (MIC 3.1-9.2 ug/ml), B. megaterium (MIC 1.5-5 ug/ml), and A.viridans (MIC 6.2-17 ug/ml), moderate activity ag
Evidence 16 Activity

Activity

MIC
Antiparasitic
1.5-5 µg/mL

Target

B. megaterium

Source & Reference

DRAMP

Other

Perinerin has marked activity (MIC < 15 ug/ml) against P. aeruginosa (MIC 3.1-9.2 ug/ml), B. megaterium (MIC 1.5-5 ug/ml), and A.viridans (MIC 6.2-17 ug/ml), moderate activity against E. coli K-12 (MIC 12.5-25 u
Evidence 17 Activity

Activity

MIC
Antiparasitic
6.2-17 µg/mL

Target

A.viridans

Source & Reference

DRAMP

Other

15 ug/ml) against P. aeruginosa (MIC 3.1-9.2 ug/ml), B. megaterium (MIC 1.5-5 ug/ml), and A.viridans (MIC 6.2-17 ug/ml), moderate activity against E. coli K-12 (MIC 12.5-25 ug/ml), S. aureus (MIC 25-50 ug/ml),
Evidence 18 Activity

Activity

MIC
Antiparasitic
12.5-25 µg/mL

Target

Escherichia coli K-12

Source & Reference

DRAMP

Other

egaterium (MIC 1.5-5 ug/ml), and A.viridans (MIC 6.2-17 ug/ml), moderate activity against E. coli K-12 (MIC 12.5-25 ug/ml), S. aureus (MIC 25-50 ug/ml), and M. luteus (MIC 25-50 ug/ml), and minor activity against
Evidence 19 Activity

Activity

MIC
Antiparasitic
25-50 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

.viridans (MIC 6.2-17 ug/ml), moderate activity against E. coli K-12 (MIC 12.5-25 ug/ml), S. aureus (MIC 25-50 ug/ml), and M. luteus (MIC 25-50 ug/ml), and minor activity against P. vulgaris (MIC 50-100 ug/m
Evidence 20 Activity

Activity

MIC
Antiparasitic
25-50 µg/mL

Target

M. luteus

Source & Reference

DRAMP

Other

erate activity against E. coli K-12 (MIC 12.5-25 ug/ml), S. aureus (MIC 25-50 ug/ml), and M. luteus (MIC 25-50 ug/ml), and minor activity against P. vulgaris (MIC 50-100 ug/ml), Fungus P. heliothis was also
Evidence 21 Activity

Activity

MIC
Antiparasitic
50-100 µg/mL

Target

P. vulgaris

Source & Reference

DRAMP

Other

S. aureus (MIC 25-50 ug/ml), and M. luteus (MIC 25-50 ug/ml), and minor activity against P. vulgaris (MIC 50-100 ug/ml), Fungus P. heliothis was also killed at a MIC concentration of 25 ug/ml.