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Peptide record

TPDB14112

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB14112
Antibacterial Anticancer Antifungal Antiparasitic Antiviral
Anti-infective peptides Cancer-related peptides
dbAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb DRAMP i2APP
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, AntiCP 2.0, and other sources, with an available 3D structural model.
Sequence
EGPVGLADPDGPASAPLGAP
Physicochemical Analysis
C78H122N20O28
RNCQHIKMFTWY
P
1787.94
2.87
0
3
7
-3
5.17
-0.095
73.50
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
4
A
0
R
0
N
2
D
0
C
1
E
0
Q
4
G
0
H
0
I
2
L
0
K
0
M
0
F
5
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 2 C: 0 E: 1 Q: 0 G: 4 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 5 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C78H122N20O28
1787.94
2.87
-3
5.17
-0.095
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Only showed weak antibacterial activity. Active against fungi: P. capsici (87.22% inhibition), V. dahliae (40.55% inhibition), F. graminearum (21.35% inhibition), and F. omysporum (15.98% inhibition). Interstingly, the same peptide has also been identified in Lactobacillus crustorum MN047 ( Yi et al., 2018 ). Inhibition zone assays reveal broad-spectrum activity. active against Gram+ S. aureus ATCC 29213, 25923 (15.3-17.4 mm), E. faecalis ATCC 29212 (10.2 mm), L. monocytogenes CMCC 54004 (12.1 mm), Gram- E. coli ATCC 25922 (12.3 mm), Salmonella CMCC 50071 (12.1 mm), C. sakazakii ATCC 29544 (15 mm), also active against antibiotic0resistant C. sakazakii (14.6-18.1 mm) and Salmonella 557D (12 mm). Found in multiple species. UPdated 7/2021
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Only showed weak antibacterial activity. Active against fungi: P. capsici (87.22% inhibition), V. dahliae (40.55% inhibition), F. graminearum (21.35% inhibition), and F. omysporum (15.98% inhibition). Interstingly, the same peptide has also been identified in Lactobacillus crustorum MN047 ( Yi et al., 2018 ). Inhibition zone assays reveal broad-spectrum activity. active against Gram+ S. aureus ATCC 29213, 25923 (15.3-17.4 mm), E. faecalis ATCC 29212 (10.2 mm), L. monocytogenes CMCC 54004 (12.1 mm), Gram- E. coli ATCC 25922 (12.3 mm), Salmonella CMCC 50071 (12.1 mm), C. sakazakii ATCC 29544 (15 mm), also active against antibiotic0resistant C. sakazakii (14.6-18.1 mm) and Salmonella 557D (12 mm). Found in multiple species. UPdated 7/2021
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Only showed weak antibacterial activity. Active against fungi: P. capsici (87.22% inhibition), V. dahliae (40.55% inhibition), F. graminearum (21.35% inhibition), and F. omysporum (15.98% inhibition). Interstingly, the same peptide has also been identified in Lactobacillus crustorum MN047 ( Yi et al., 2018 ). Inhibition zone assays reveal broad-spectrum activity. active against Gram+ S. aureus ATCC 29213, 25923 (15.3-17.4 mm), E. faecalis ATCC 29212 (10.2 mm), L. monocytogenes CMCC 54004 (12.1 mm), Gram- E. coli ATCC 25922 (12.3 mm), Salmonella CMCC 50071 (12.1 mm), C. sakazakii ATCC 29544 (15 mm), also active against antibiotic0resistant C. sakazakii (14.6-18.1 mm) and Salmonella 557D (12 mm). Found in multiple species. UPdated 7/2021
Evidence 4 Activity

Activity

Antiviral

Source & Reference

DRAMP

Other

Only showed weak antibacterial activity. Active against fungi: P. capsici (87.22% inhibition), V. dahliae (40.55% inhibition), F. graminearum (21.35% inhibition), and F. omysporum (15.98% inhibition). Interstingly, the same peptide has also been identified in Lactobacillus crustorum MN047 ( Yi et al., 2018 ). Inhibition zone assays reveal broad-spectrum activity. active against Gram+ S. aureus ATCC 29213, 25923 (15.3-17.4 mm), E. faecalis ATCC 29212 (10.2 mm), L. monocytogenes CMCC 54004 (12.1 mm), Gram- E. coli ATCC 25922 (12.3 mm), Salmonella CMCC 50071 (12.1 mm), C. sakazakii ATCC 29544 (15 mm), also active against antibiotic0resistant C. sakazakii (14.6-18.1 mm) and Salmonella 557D (12 mm). Found in multiple species. UPdated 7/2021