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Peptide record

TPDB14098

Antibacterial Antifungal standard
149 amino acids
Basic Information
3D PDB MODEL
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TPDB14098
Antibacterial Antifungal
Anti-infective peptides
dbAMP Peptipedia Antifungipept
standard
No
A 149-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from dbAMP, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
EEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGWEWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C734H1104N202O224S7
S
16566.48
7.64
18
14
51
+1
1.78
-0.496
60.87
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
43805
2.64
52
Residue Composition
number
9
A
8
R
7
N
6
D
6
C
8
E
3
Q
11
G
3
H
4
I
11
L
7
K
1
M
5
F
10
P
23
S
6
T
6
W
7
Y
8
V
Amino Acid Distribution
A: 9 R: 8 N: 7 D: 6 C: 6 E: 8 Q: 3 G: 11 H: 3 I: 4 L: 11 K: 7 M: 1 F: 5 P: 10 S: 23 T: 6 W: 6 Y: 7 V: 8
Chemical Descriptors
149 reviewed residue count
C734H1104N202O224S7 sequence-only estimate (linear, free termini)
16566.48 sequence-only estimate (linear, free termini)
7.64 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
1.78 sequence-only estimate (linear, free termini)
-0.496 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram-positive L. monocytogenes, L. innocua, and E. faecalis. Its interaction with peptidoglycan carbohydrate depends on sugar chain length PNAS 2010 .
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram-positive L. monocytogenes, L. innocua, and E. faecalis. Its interaction with peptidoglycan carbohydrate depends on sugar chain length PNAS 2010 .