TPDB

3D PDB MODEL

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TPDB ID TPDB14087

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

dbAMP Peptipedia Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 132-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from dbAMP, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

DVYKGGGGGRYGGGRYGGGGGYGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGRGGGYGGGGGYGGGYGGGYGGGKYK

FASTA

>TPDB14087|Antibacterial;Antifungal|length=132
DVYKGGGGGRYGGGRYGGGGGYGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGGLGGGGLGGGKGLGGGGLGGGGLGGGRGGGYGGGGGYGGGYGGGYGGGKYK

Formula C432H669N147O144

Absent Amino Acids ANCEQHIMFPSTW

Common Amino Acids G

Mass 10225.96

PI 10.21

Basic Residues 9

Acidic Residues 1

Hydrophobic Residues 26

Net Charge +8

Boman Index -6.79

Hydrophobicity -0.193

Aliphatic Index 49.47

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 13410

Absorbance 280nm 131.14

Polar Residues 9

number

0

A

3

R

0

N

1

D

0

C

0

E

0

Q

96

G

0

H

0

I

16

L

6

K

0

M

0

F

0

P

0

S

0

T

0

W

9

Y

1

V

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 96 H: 0 I: 0 L: 16 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 9 V: 1

Length

132

Formula

C432H669N147O144

Mass

10225.96

PI

10.21

Net Charge

+8

Boman Index

-6.79

Hydrophobicity

-0.193

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.3-5.6 µM

Target

Target Organism Escherichia coli SBS363

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli SBS363 (MIC 2.3-5.6 uM) and C. albicans MDM8 (MIC 1.15-2.3 uM). Updated 2/2020

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.15-2.3 µM

Target

Target Organism Candida albicans MDM8

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli SBS363 (MIC 2.3-5.6 uM) and C. albicans MDM8 (MIC 1.15-2.3 uM). Updated 2/2020

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.3-5.6 µM

Target

Target Organism Escherichia coli SBS363

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli SBS363 (MIC 2.3-5.6 uM) and C. albicans MDM8 (MIC 1.15-2.3 uM). Updated 2/2020

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.15-2.3 µM

Target

Target Organism Candida albicans MDM8

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli SBS363 (MIC 2.3-5.6 uM) and C. albicans MDM8 (MIC 1.15-2.3 uM). Updated 2/2020