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Peptide record

TPDB14038

Antibacterial Antifungal standard
101 amino acids
Basic Information
3D PDB MODEL
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TPDB14038
Antibacterial Antifungal
Anti-infective peptides
dbAMP Peptipedia Antifungipept
standard
No
A 101-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from dbAMP, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
DGIWTQLIFTLVKNLATLWQSGDFQFLDHECHYRIKPTFRRLKWKYKGKFWCPSWTSITGRATKSSRSGAVEHSVRNFVGQAKSSGLITQRQAEQFISQYN
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C537H816N152O146S2
M
S
11801.44
10.48
18
6
37
+9
1.96
-0.552
66.63
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
32095
2.72
34
Residue Composition
number
5
A
7
R
3
N
3
D
2
C
3
E
8
Q
7
G
3
H
6
I
7
L
8
K
0
M
7
F
2
P
10
S
8
T
5
W
3
Y
4
V
Amino Acid Distribution
A: 5 R: 7 N: 3 D: 3 C: 2 E: 3 Q: 8 G: 7 H: 3 I: 6 L: 7 K: 8 M: 0 F: 7 P: 2 S: 10 T: 8 W: 5 Y: 3 V: 4
Chemical Descriptors
101 reviewed residue count
C537H816N152O146S2 sequence-only estimate (linear, free termini)
11801.44 sequence-only estimate (linear, free termini)
10.48 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
1.96 sequence-only estimate (linear, free termini)
-0.552 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. typhimurium 7 strains (4 strains: minimal antibacterial dose 1.3-10 ug 3 strains> 20 ug), S. minnesota R595 and 1114W (0.12-7.45 ug) and multiple strains such as S-aureus 209P were insenstive at 20 ug dose. Peptide sequence was established in 1987 (J. Biochem. 101 (6), 1321-1330) and 3D structure was determined in 1993 (EMBO J. 12 (9), 3351-3356). Warning: the recombinant protein contains four additional residues at the N terminus (Glu-Ala-Glu-Ala) not present in the native protein. Updated 11/2014 8/2025
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. typhimurium 7 strains (4 strains: minimal antibacterial dose 1.3-10 ug 3 strains> 20 ug), S. minnesota R595 and 1114W (0.12-7.45 ug) and multiple strains such as S-aureus 209P were insenstive at 20 ug dose. Peptide sequence was established in 1987 (J. Biochem. 101 (6), 1321-1330) and 3D structure was determined in 1993 (EMBO J. 12 (9), 3351-3356). Warning: the recombinant protein contains four additional residues at the N terminus (Glu-Ala-Glu-Ala) not present in the native protein. Updated 11/2014 8/2025