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Peptide record

TPDB13953

Antibacterial Anticancer Antifungal Antiparasitic standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13953
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
ALWKTLLKKVGKVAGKAVLNAVTNMANQNEQ
Physicochemical Analysis
C148H253N43O42S1
RDCHIFPSY
AK
3338.96
10.71
5
1
15
+4
5.22
-0.135
103.87
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
164.72
8
Residue Composition
number
5
A
0
R
4
N
0
D
0
C
1
E
2
Q
2
G
0
H
0
I
4
L
5
K
1
M
0
F
0
P
0
S
2
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 5 R: 0 N: 4 D: 0 C: 0 E: 1 Q: 2 G: 2 H: 0 I: 0 L: 4 K: 5 M: 1 F: 0 P: 0 S: 0 T: 2 W: 1 Y: 0 V: 4
Chemical Descriptors
31
C148H253N43O42S1
3338.96
10.71
+4
5.22
-0.135
Evidence Records 36 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.6-12.5 µM

Target

Escherichia coli ATCC 8739 or K12 or ML35p or resistant p7

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli ATCC 8739 or K12 or ML35p or resistant p7 (MIC 1.6-12.5 uM), P. aeruginosa ATCC 9027 or ATCC 27853 (MIC 6.3-50 uM), K. pneumoniae CIP 52.211 (MIC 0.8
Evidence 2 Activity

Activity

MIC
Antibacterial
6.3-50 µM

Target

Pseudomonas aeruginosa ATCC 9027 or ATCC 27853

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli ATCC 8739 or K12 or ML35p or resistant p7 (MIC 1.6-12.5 uM), P. aeruginosa ATCC 9027 or ATCC 27853 (MIC 6.3-50 uM), K. pneumoniae CIP 52.211 (MIC 0.8 uM), K. oxytoca CIP 7932 (MIC 12.5 uM), S. enterica CI
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Klebsiella oxytoca CIP 7932

Source & Reference

dbAMP DRAMP

Other

eruginosa ATCC 9027 or ATCC 27853 (MIC 6.3-50 uM), K. pneumoniae CIP 52.211 (MIC 0.8 uM), K. oxytoca CIP 7932 (MIC 12.5 uM), S. enterica CIP 8297 (MIC 50 uM), Y. ruckeri ATGG 29473 (MIC 25 uM), Gram+ S. aureus ATC
Evidence 4 Activity

Activity

MIC
Antibacterial
50 µM

Target

S. enterica CIP 8297

Source & Reference

dbAMP DRAMP

Other

MIC 6.3-50 uM), K. pneumoniae CIP 52.211 (MIC 0.8 uM), K. oxytoca CIP 7932 (MIC 12.5 uM), S. enterica CIP 8297 (MIC 50 uM), Y. ruckeri ATGG 29473 (MIC 25 uM), Gram+ S. aureus ATCC 6538 or ST 1065 or MRSA (MIC 12.
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µM

Target

Y. ruckeri ATGG 29473

Source & Reference

dbAMP DRAMP

Other

52.211 (MIC 0.8 uM), K. oxytoca CIP 7932 (MIC 12.5 uM), S. enterica CIP 8297 (MIC 50 uM), Y. ruckeri ATGG 29473 (MIC 25 uM), Gram+ S. aureus ATCC 6538 or ST 1065 or MRSA (MIC 12.5-25 uM) also MIC >100 uM AMP-resis
Evidence 6 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

Staphylococcus aureus ATCC 6538 or ST 1065 or MRSA

Source & Reference

dbAMP DRAMP

Other

(MIC 12.5 uM), S. enterica CIP 8297 (MIC 50 uM), Y. ruckeri ATGG 29473 (MIC 25 uM), Gram+ S. aureus ATCC 6538 or ST 1065 or MRSA (MIC 12.5-25 uM) also MIC >100 uM AMP-resistant? S. epidermidis BM 3302 (MIC 12.5 uM), L. monocytogenes SO
Evidence 7 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus epidermidis BM 3302

Source & Reference

dbAMP DRAMP

Other

+ S. aureus ATCC 6538 or ST 1065 or MRSA (MIC 12.5-25 uM) also MIC >100 uM AMP-resistant? S. epidermidis BM 3302 (MIC 12.5 uM), L. monocytogenes SOR 100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae AT
Evidence 8 Activity

Activity

MIC
Antibacterial
100 µM

Target

L. monocytogenes SOR 100

Source & Reference

dbAMP DRAMP

Other

SA (MIC 12.5-25 uM) also MIC >100 uM AMP-resistant? S. epidermidis BM 3302 (MIC 12.5 uM), L. monocytogenes SOR 100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP
Evidence 9 Activity

Activity

MIC
Antibacterial
100 µM

Target

Enterococcus faecalis CIP A186

Source & Reference

dbAMP DRAMP

Other

P-resistant? S. epidermidis BM 3302 (MIC 12.5 uM), L. monocytogenes SOR 100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP 103015 (MIC 12.5 uM), and K. rhizop
Evidence 10 Activity

Activity

MIC
Antibacterial
100 µM

Target

L. garvieae ATCC 43921

Source & Reference

dbAMP DRAMP

Other

(MIC 12.5 uM), L. monocytogenes SOR 100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP 103015 (MIC 12.5 uM), and K. rhizophila ATCC 9341 (MIC 0.8 uM).
Evidence 11 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Enterococcus faecalis CIP 103015

Source & Reference

dbAMP DRAMP

Other

100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP 103015 (MIC 12.5 uM), and K. rhizophila ATCC 9341 (MIC 0.8 uM).
Evidence 12 Activity

Activity

MIC
Antibacterial
0.8 µM

Target

K. rhizophila ATCC 9341

Source & Reference

dbAMP DRAMP

Other

C 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP 103015 (MIC 12.5 uM), and K. rhizophila ATCC 9341 (MIC 0.8 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
1.6-12.5 µM

Target

Escherichia coli ATCC 8739 or K12 or ML35p or resistant p7

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- E. coli ATCC 8739 or K12 or ML35p or resistant p7 (MIC 1.6-12.5 uM), P. aeruginosa ATCC 9027 or ATCC 27853 (MIC 6.3-50 uM), K. pneumoniae CIP 52.211 (MIC 0.8
Evidence 14 Activity

Activity

MIC
Antifungal
6.3-50 µM

Target

Pseudomonas aeruginosa ATCC 9027 or ATCC 27853

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against Gram- E. coli ATCC 8739 or K12 or ML35p or resistant p7 (MIC 1.6-12.5 uM), P. aeruginosa ATCC 9027 or ATCC 27853 (MIC 6.3-50 uM), K. pneumoniae CIP 52.211 (MIC 0.8 uM), K. oxytoca CIP 7932 (MIC 12.5 uM), S. enterica CI
Evidence 15 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Klebsiella oxytoca CIP 7932

Source & Reference

dbAMP DRAMP Antifungipept

Other

eruginosa ATCC 9027 or ATCC 27853 (MIC 6.3-50 uM), K. pneumoniae CIP 52.211 (MIC 0.8 uM), K. oxytoca CIP 7932 (MIC 12.5 uM), S. enterica CIP 8297 (MIC 50 uM), Y. ruckeri ATGG 29473 (MIC 25 uM), Gram+ S. aureus ATC
Evidence 16 Activity

Activity

MIC
Antifungal
50 µM

Target

S. enterica CIP 8297

Source & Reference

dbAMP DRAMP Antifungipept

Other

MIC 6.3-50 uM), K. pneumoniae CIP 52.211 (MIC 0.8 uM), K. oxytoca CIP 7932 (MIC 12.5 uM), S. enterica CIP 8297 (MIC 50 uM), Y. ruckeri ATGG 29473 (MIC 25 uM), Gram+ S. aureus ATCC 6538 or ST 1065 or MRSA (MIC 12.
Evidence 17 Activity

Activity

MIC
Antifungal
25 µM

Target

Y. ruckeri ATGG 29473

Source & Reference

dbAMP DRAMP Antifungipept

Other

52.211 (MIC 0.8 uM), K. oxytoca CIP 7932 (MIC 12.5 uM), S. enterica CIP 8297 (MIC 50 uM), Y. ruckeri ATGG 29473 (MIC 25 uM), Gram+ S. aureus ATCC 6538 or ST 1065 or MRSA (MIC 12.5-25 uM) also MIC >100 uM AMP-resis
Evidence 18 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

Staphylococcus aureus ATCC 6538 or ST 1065 or MRSA

Source & Reference

dbAMP DRAMP Antifungipept

Other

(MIC 12.5 uM), S. enterica CIP 8297 (MIC 50 uM), Y. ruckeri ATGG 29473 (MIC 25 uM), Gram+ S. aureus ATCC 6538 or ST 1065 or MRSA (MIC 12.5-25 uM) also MIC >100 uM AMP-resistant? S. epidermidis BM 3302 (MIC 12.5 uM), L. monocytogenes SO
Evidence 19 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus epidermidis BM 3302

Source & Reference

dbAMP DRAMP Antifungipept

Other

+ S. aureus ATCC 6538 or ST 1065 or MRSA (MIC 12.5-25 uM) also MIC >100 uM AMP-resistant? S. epidermidis BM 3302 (MIC 12.5 uM), L. monocytogenes SOR 100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae AT
Evidence 20 Activity

Activity

MIC
Antifungal
100 µM

Target

L. monocytogenes SOR 100

Source & Reference

dbAMP DRAMP Antifungipept

Other

SA (MIC 12.5-25 uM) also MIC >100 uM AMP-resistant? S. epidermidis BM 3302 (MIC 12.5 uM), L. monocytogenes SOR 100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP
Evidence 21 Activity

Activity

MIC
Antifungal
100 µM

Target

Enterococcus faecalis CIP A186

Source & Reference

dbAMP DRAMP Antifungipept

Other

P-resistant? S. epidermidis BM 3302 (MIC 12.5 uM), L. monocytogenes SOR 100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP 103015 (MIC 12.5 uM), and K. rhizop
Evidence 22 Activity

Activity

MIC
Antifungal
100 µM

Target

L. garvieae ATCC 43921

Source & Reference

dbAMP DRAMP Antifungipept

Other

(MIC 12.5 uM), L. monocytogenes SOR 100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP 103015 (MIC 12.5 uM), and K. rhizophila ATCC 9341 (MIC 0.8 uM).
Evidence 23 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Enterococcus faecalis CIP 103015

Source & Reference

dbAMP DRAMP Antifungipept

Other

100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP 103015 (MIC 12.5 uM), and K. rhizophila ATCC 9341 (MIC 0.8 uM).
Evidence 24 Activity

Activity

MIC
Antifungal
0.8 µM

Target

K. rhizophila ATCC 9341

Source & Reference

dbAMP DRAMP Antifungipept

Other

C 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP 103015 (MIC 12.5 uM), and K. rhizophila ATCC 9341 (MIC 0.8 uM).
Evidence 25 Activity

Activity

MIC
Antiparasitic
1.6-12.5 µM

Target

Escherichia coli ATCC 8739 or K12 or ML35p or resistant p7

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- E. coli ATCC 8739 or K12 or ML35p or resistant p7 (MIC 1.6-12.5 uM), P. aeruginosa ATCC 9027 or ATCC 27853 (MIC 6.3-50 uM), K. pneumoniae CIP 52.211 (MIC 0.8
Evidence 26 Activity

Activity

MIC
Antiparasitic
6.3-50 µM

Target

Pseudomonas aeruginosa ATCC 9027 or ATCC 27853

Source & Reference

DRAMP

Other

Active against Gram- E. coli ATCC 8739 or K12 or ML35p or resistant p7 (MIC 1.6-12.5 uM), P. aeruginosa ATCC 9027 or ATCC 27853 (MIC 6.3-50 uM), K. pneumoniae CIP 52.211 (MIC 0.8 uM), K. oxytoca CIP 7932 (MIC 12.5 uM), S. enterica CI
Evidence 27 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Klebsiella oxytoca CIP 7932

Source & Reference

DRAMP

Other

eruginosa ATCC 9027 or ATCC 27853 (MIC 6.3-50 uM), K. pneumoniae CIP 52.211 (MIC 0.8 uM), K. oxytoca CIP 7932 (MIC 12.5 uM), S. enterica CIP 8297 (MIC 50 uM), Y. ruckeri ATGG 29473 (MIC 25 uM), Gram+ S. aureus ATC
Evidence 28 Activity

Activity

MIC
Antiparasitic
50 µM

Target

S. enterica CIP 8297

Source & Reference

DRAMP

Other

MIC 6.3-50 uM), K. pneumoniae CIP 52.211 (MIC 0.8 uM), K. oxytoca CIP 7932 (MIC 12.5 uM), S. enterica CIP 8297 (MIC 50 uM), Y. ruckeri ATGG 29473 (MIC 25 uM), Gram+ S. aureus ATCC 6538 or ST 1065 or MRSA (MIC 12.
Evidence 29 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Y. ruckeri ATGG 29473

Source & Reference

DRAMP

Other

52.211 (MIC 0.8 uM), K. oxytoca CIP 7932 (MIC 12.5 uM), S. enterica CIP 8297 (MIC 50 uM), Y. ruckeri ATGG 29473 (MIC 25 uM), Gram+ S. aureus ATCC 6538 or ST 1065 or MRSA (MIC 12.5-25 uM) also MIC >100 uM AMP-resis
Evidence 30 Activity

Activity

MIC
Antiparasitic
12.5-25 µM

Target

Staphylococcus aureus ATCC 6538 or ST 1065 or MRSA

Source & Reference

DRAMP

Other

(MIC 12.5 uM), S. enterica CIP 8297 (MIC 50 uM), Y. ruckeri ATGG 29473 (MIC 25 uM), Gram+ S. aureus ATCC 6538 or ST 1065 or MRSA (MIC 12.5-25 uM) also MIC >100 uM AMP-resistant? S. epidermidis BM 3302 (MIC 12.5 uM), L. monocytogenes SO
Evidence 31 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Staphylococcus epidermidis BM 3302

Source & Reference

DRAMP

Other

+ S. aureus ATCC 6538 or ST 1065 or MRSA (MIC 12.5-25 uM) also MIC >100 uM AMP-resistant? S. epidermidis BM 3302 (MIC 12.5 uM), L. monocytogenes SOR 100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae AT
Evidence 32 Activity

Activity

MIC
Antiparasitic
100 µM

Target

L. monocytogenes SOR 100

Source & Reference

DRAMP

Other

SA (MIC 12.5-25 uM) also MIC >100 uM AMP-resistant? S. epidermidis BM 3302 (MIC 12.5 uM), L. monocytogenes SOR 100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP
Evidence 33 Activity

Activity

MIC
Antiparasitic
100 µM

Target

Enterococcus faecalis CIP A186

Source & Reference

DRAMP

Other

P-resistant? S. epidermidis BM 3302 (MIC 12.5 uM), L. monocytogenes SOR 100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP 103015 (MIC 12.5 uM), and K. rhizop
Evidence 34 Activity

Activity

MIC
Antiparasitic
100 µM

Target

L. garvieae ATCC 43921

Source & Reference

DRAMP

Other

(MIC 12.5 uM), L. monocytogenes SOR 100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP 103015 (MIC 12.5 uM), and K. rhizophila ATCC 9341 (MIC 0.8 uM).
Evidence 35 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Enterococcus faecalis CIP 103015

Source & Reference

DRAMP

Other

100 (MIC 100 uM), E. faecalis CIP A186 (MIC 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP 103015 (MIC 12.5 uM), and K. rhizophila ATCC 9341 (MIC 0.8 uM).
Evidence 36 Activity

Activity

MIC
Antiparasitic
0.8 µM

Target

K. rhizophila ATCC 9341

Source & Reference

DRAMP

Other

C 100 uM), L. garvieae ATCC 43921 (MIC 100 uM), E. faecalis CIP 103015 (MIC 12.5 uM), and K. rhizophila ATCC 9341 (MIC 0.8 uM).