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Peptide record

TPDB13885

Antibacterial Anticancer Antifungal Toxicity standard
53 amino acids
Basic Information
3D PDB MODEL
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TPDB13885
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
dbAMP Peptipedia dbACP Antifungipept
standard
No
A 53-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, Peptipedia, dbACP, and other sources, with an available 3D structural model.
Sequence
ACVNQCPDAIDRFIVKDKGCHGVEKKYYKQVYVACMNGQHLYCRTEWGGPCQL
Physicochemical Analysis
C265H407N75O75S7
S
C
6068.02
8.01
9
5
19
+2
10.16
-0.428
62.45
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11835
195.04
17
Residue Composition
number
3
A
2
R
2
N
3
D
6
C
2
E
4
Q
5
G
2
H
2
I
2
L
5
K
1
M
1
F
2
P
0
S
1
T
1
W
4
Y
5
V
Amino Acid Distribution
A: 3 R: 2 N: 2 D: 3 C: 6 E: 2 Q: 4 G: 5 H: 2 I: 2 L: 2 K: 5 M: 1 F: 1 P: 2 S: 0 T: 1 W: 1 Y: 4 V: 5
Chemical Descriptors
53
C265H407N75O75S7
6068.02
8.01
+2
10.16
-0.428
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

s. Active against MRSA

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
i-TB) residing inside the macrophages without any antagonistic activity against macrophages. Active against MRSA (MIC 4 uM), VRE (MIC >16 uM), S. mutans strain DIGK119 (MIC 16 uM), G-parahaemolysans strain SKVG1 (
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

S. mutans strain DIGK119

Source & Reference

dbAMP

Other

agonistic activity against macrophages. Active against MRSA (MIC 4 uM), VRE (MIC >16 uM), S. mutans strain DIGK119 (MIC 16 uM), G-parahaemolysans strain SKVG1 (MIC > 24 uM), and S-gordonii (MIC > 24 uM). Warning: oth
Evidence 3 Activity

Activity

MIC
Antifungal
4 µM

Target

s. Active against MRSA

Source & Reference

dbAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
i-TB) residing inside the macrophages without any antagonistic activity against macrophages. Active against MRSA (MIC 4 uM), VRE (MIC >16 uM), S. mutans strain DIGK119 (MIC 16 uM), G-parahaemolysans strain SKVG1 (
Evidence 4 Activity

Activity

MIC
Antifungal
16 µM

Target

S. mutans strain DIGK119

Source & Reference

dbAMP Antifungipept

Other

agonistic activity against macrophages. Active against MRSA (MIC 4 uM), VRE (MIC >16 uM), S. mutans strain DIGK119 (MIC 16 uM), G-parahaemolysans strain SKVG1 (MIC > 24 uM), and S-gordonii (MIC > 24 uM). Warning: oth
Evidence 5 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Laterosporulin10: a novel defensin like Class IId bacteriocin from Brevibacillus sp. strain SKDU10 with inhibitory activity against microbial pathogens. | Microbiology | 2016
Evidence 6 Activity

Activity

<20% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
<20% Hemolysis | 100 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Laterosporulin10: a novel defensin like Class IId bacteriocin from Brevibacillus sp. strain SKDU10 with inhibitory activity against microbial pathogens. | Microbiology | 2016
Evidence 7 Activity

Activity

<10% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
<10% Hemolysis | 40 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Anticancer properties of a defensin like class IId bacteriocin Laterosporulin10 | Sci Rep | 2017
Evidence 8 Activity

Activity

LC50
Toxicity
>20 µM
Cytotoxic
LC50 | >20 | µM | target cell: Human epithelial prostate cells RWPE-1

Target

Human epithelial prostate cells RWPE-1

Source & Reference

NA
DBAASP
Anticancer properties of a defensin like class IId bacteriocin Laterosporulin10 | Sci Rep | 2017
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2017 Apr 19 7:46541.