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Peptide record

TPDB13841

Antibacterial Antifungal Antiparasitic standard

46 amino acids

3D PDB MODEL

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TPDB ID TPDB13841

Activity

Antibacterial Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept dbAMP 3.0 i2APP

Sequence_Type

standard

Has_Modification No

Description A 46-aa standard natural multi-activity (Antibacterial, Antifungal, and Antiparasitic) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

LIGSLFRGAKAIFRGARQGWRSHKAVSRYRARYVRRPVIYYHRVYP

FASTA

>TPDB13841|Antibacterial;Antifungal;Antiparasitic|length=46
LIGSLFRGAKAIFRGARQGWRSHKAVSRYRARYVRRPVIYYHRVYP

Formula C255H398N84O56

Absent Amino Acids NDCEMT

Common Amino Acids R

Mass 5536.49

PI 12.24

Basic Residues 14

Acidic Residues 0

Hydrophobic Residues 22

Net Charge +12

Boman Index 2.48

Hydrophobicity -0.539

Aliphatic Index 78.48

Half Life

Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 12950

Absorbance 280nm 233.90

Polar Residues 9

number

Amino Acid Distribution

A: 5 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 4 H: 2 I: 3 L: 2 K: 2 M: 0 F: 2 P: 2 S: 3 T: 0 W: 1 Y: 5 V: 4

Length

Formula

C255H398N84O56

Mass

5536.49

12.24

Net Charge

+12

Boman Index

2.48

Hydrophobicity

-0.539

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.26-4.52 µM

Target

Target Organism S. iniae

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

fish pathogens S. iniae (MIC 2.26-4.52 uM), L. garvieae (MIC 9.03 uM), V. anguillarum (MIC 4.52 uM), A-salmonicida (MIC >36.12 uM),

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.03 µM

Target

Target Organism L. garvieae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

fish pathogens S. iniae (MIC 2.26-4.52 uM), L. garvieae (MIC 9.03 uM), V. anguillarum (MIC 4.52 uM), A-salmonicida (MIC >36.12 uM), human pathogens E. faecalis

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.52 µM

Target

Target Organism V. anguillarum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

fish pathogens S. iniae (MIC 2.26-4.52 uM), L. garvieae (MIC 9.03 uM), V. anguillarum (MIC 4.52 uM), A-salmonicida (MIC >36.12 uM), human pathogens E. faecalis (MIC 4.52 uM), S. aureus (MIC

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.52 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

IC 9.03 uM), V. anguillarum (MIC 4.52 uM), A-salmonicida (MIC >36.12 uM), human pathogens E. faecalis (MIC 4.52 uM), S. aureus (MIC 4.52 uM), S. flexneri (MIC 1.13-2.26 uM), and E. coli (MIC 1.13 uM). Its

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.52 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

(MIC 4.52 uM), A-salmonicida (MIC >36.12 uM), human pathogens E. faecalis (MIC 4.52 uM), S. aureus (MIC 4.52 uM), S. flexneri (MIC 1.13-2.26 uM), and E. coli (MIC 1.13 uM). Its minimum parasiticidal con

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.13-2.26 µM

Target

Target Organism S. flexneri

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

cida (MIC >36.12 uM), human pathogens E. faecalis (MIC 4.52 uM), S. aureus (MIC 4.52 uM), S. flexneri (MIC 1.13-2.26 uM), and E. coli (MIC 1.13 uM). Its minimum parasiticidal concentrations (PCmin 0.56 uM PC10

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.13 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

s E. faecalis (MIC 4.52 uM), S. aureus (MIC 4.52 uM), S. flexneri (MIC 1.13-2.26 uM), and E. coli (MIC 1.13 uM). Its minimum parasiticidal concentrations (PCmin 0.56 uM PC100 1.10 uM). Updated 4/2024

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.26-4.52 µM

Target

Target Organism S. iniae

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

fish pathogens S. iniae (MIC 2.26-4.52 uM), L. garvieae (MIC 9.03 uM), V. anguillarum (MIC 4.52 uM), A-salmonicida (MIC >36.12 uM),

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.03 µM

Target

Target Organism L. garvieae

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

fish pathogens S. iniae (MIC 2.26-4.52 uM), L. garvieae (MIC 9.03 uM), V. anguillarum (MIC 4.52 uM), A-salmonicida (MIC >36.12 uM), human pathogens E. faecalis

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.52 µM

Target

Target Organism V. anguillarum

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

fish pathogens S. iniae (MIC 2.26-4.52 uM), L. garvieae (MIC 9.03 uM), V. anguillarum (MIC 4.52 uM), A-salmonicida (MIC >36.12 uM), human pathogens E. faecalis (MIC 4.52 uM), S. aureus (MIC

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.52 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.52 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.13-2.26 µM

Target

Target Organism S. flexneri

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.13 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

s E. faecalis (MIC 4.52 uM), S. aureus (MIC 4.52 uM), S. flexneri (MIC 1.13-2.26 uM), and E. coli (MIC 1.13 uM). Its minimum parasiticidal concentrations (PCmin 0.56 uM PC100 1.10 uM). Updated 4/2024

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 2.26-4.52 µM

Target

Target Organism S. iniae

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

fish pathogens S. iniae (MIC 2.26-4.52 uM), L. garvieae (MIC 9.03 uM), V. anguillarum (MIC 4.52 uM), A-salmonicida (MIC >36.12 uM),

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 9.03 µM

Target

Target Organism L. garvieae

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

fish pathogens S. iniae (MIC 2.26-4.52 uM), L. garvieae (MIC 9.03 uM), V. anguillarum (MIC 4.52 uM), A-salmonicida (MIC >36.12 uM), human pathogens E. faecalis

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.52 µM

Target

Target Organism V. anguillarum

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

fish pathogens S. iniae (MIC 2.26-4.52 uM), L. garvieae (MIC 9.03 uM), V. anguillarum (MIC 4.52 uM), A-salmonicida (MIC >36.12 uM), human pathogens E. faecalis (MIC 4.52 uM), S. aureus (MIC

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.52 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.52 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.13-2.26 µM

Target

Target Organism S. flexneri

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.13 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

s E. faecalis (MIC 4.52 uM), S. aureus (MIC 4.52 uM), S. flexneri (MIC 1.13-2.26 uM), and E. coli (MIC 1.13 uM). Its minimum parasiticidal concentrations (PCmin 0.56 uM PC100 1.10 uM). Updated 4/2024