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Peptide record

TPDB13838

Antibacterial Anticancer Antifungal Antiparasitic Antiviral standard

46 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB13838

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 46-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

KSCCRNTVARNCYNVCRIPGTPRPVCAATCDCKLITGTKCPPGYEK

FASTA

>TPDB13838|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral|length=46
KSCCRNTVARNCYNVCRIPGTPRPVCAATCDCKLITGTKCPPGYEK

Formula C207H345N65O62S8

Absent Amino Acids QHMFW

Common Amino Acids C

Mass 4992.89

PI 8.74

Basic Residues 8

Acidic Residues 2

Hydrophobic Residues 11

Net Charge +6

Boman Index 9.54

Hydrophobicity -0.357

Aliphatic Index 50.87

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 3480

Absorbance 280nm 69.70

Polar Residues 19

number

Amino Acid Distribution

A: 3 R: 4 N: 3 D: 1 C: 8 E: 1 Q: 0 G: 3 H: 0 I: 2 L: 1 K: 4 M: 0 F: 0 P: 5 S: 1 T: 5 W: 0 Y: 2 V: 3

Length

Formula

C207H345N65O62S8

Mass

4992.89

8.74

Net Charge

Boman Index

9.54

Hydrophobicity

-0.357

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 11 µg/mL

Target

Target Organism E. carotovora

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against bacteria E. carotovora (IC50 11 ug/ml), A. radiobacter (IC50 15 ug/ml), A. rhizogenes (IC50 20 ug/ml), C. michiganensis (IC50 14

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 15 µg/mL

Target

Target Organism A. radiobacter

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against bacteria E. carotovora (IC50 11 ug/ml), A. radiobacter (IC50 15 ug/ml), A. rhizogenes (IC50 20 ug/ml), C. michiganensis (IC50 14 ug/ml), C. flaccumfaciens (IC50

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 20 µg/mL

Target

Target Organism A. rhizogenes

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against bacteria E. carotovora (IC50 11 ug/ml), A. radiobacter (IC50 15 ug/ml), A. rhizogenes (IC50 20 ug/ml), C. michiganensis (IC50 14 ug/ml), C. flaccumfaciens (IC50 13 ug/ml), fungi F. oxysporum

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 14 µg/mL

Target

Target Organism C. michiganensis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

arotovora (IC50 11 ug/ml), A. radiobacter (IC50 15 ug/ml), A. rhizogenes (IC50 20 ug/ml), C. michiganensis (IC50 14 ug/ml), C. flaccumfaciens (IC50 13 ug/ml), fungi F. oxysporum (IC50 2 ug/ml), and G. candidum (I

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 13 µg/mL

Target

Target Organism C. flaccumfaciens

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

obacter (IC50 15 ug/ml), A. rhizogenes (IC50 20 ug/ml), C. michiganensis (IC50 14 ug/ml), C. flaccumfaciens (IC50 13 ug/ml), fungi F. oxysporum (IC50 2 ug/ml), and G. candidum (IC50 2 ug/ml). Updated 7/2021

Evidence 6 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

C50 20 ug/ml), C. michiganensis (IC50 14 ug/ml), C. flaccumfaciens (IC50 13 ug/ml), fungi F. oxysporum (IC50 2 ug/ml), and G. candidum (IC50 2 ug/ml). Updated 7/2021

Evidence 7 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism G. candidum

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

IC50 14 ug/ml), C. flaccumfaciens (IC50 13 ug/ml), fungi F. oxysporum (IC50 2 ug/ml), and G. candidum (IC50 2 ug/ml). Updated 7/2021

Evidence 8 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 11 µg/mL

Target

Target Organism E. carotovora

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against bacteria E. carotovora (IC50 11 ug/ml), A. radiobacter (IC50 15 ug/ml), A. rhizogenes (IC50 20 ug/ml), C. michiganensis (IC50 14

Evidence 9 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 15 µg/mL

Target

Target Organism A. radiobacter

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against bacteria E. carotovora (IC50 11 ug/ml), A. radiobacter (IC50 15 ug/ml), A. rhizogenes (IC50 20 ug/ml), C. michiganensis (IC50 14 ug/ml), C. flaccumfaciens (IC50

Evidence 10 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 20 µg/mL

Target

Target Organism A. rhizogenes

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 14 µg/mL

Target

Target Organism C. michiganensis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 13 µg/mL

Target

Target Organism C. flaccumfaciens

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism F. oxysporum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

C50 20 ug/ml), C. michiganensis (IC50 14 ug/ml), C. flaccumfaciens (IC50 13 ug/ml), fungi F. oxysporum (IC50 2 ug/ml), and G. candidum (IC50 2 ug/ml). Updated 7/2021

Evidence 14 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism G. candidum

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

IC50 14 ug/ml), C. flaccumfaciens (IC50 13 ug/ml), fungi F. oxysporum (IC50 2 ug/ml), and G. candidum (IC50 2 ug/ml). Updated 7/2021

Evidence 15 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 11 µg/mL

Target

Target Organism E. carotovora

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against bacteria E. carotovora (IC50 11 ug/ml), A. radiobacter (IC50 15 ug/ml), A. rhizogenes (IC50 20 ug/ml), C. michiganensis (IC50 14

Evidence 16 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 15 µg/mL

Target

Target Organism A. radiobacter

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against bacteria E. carotovora (IC50 11 ug/ml), A. radiobacter (IC50 15 ug/ml), A. rhizogenes (IC50 20 ug/ml), C. michiganensis (IC50 14 ug/ml), C. flaccumfaciens (IC50

Evidence 17 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 20 µg/mL

Target

Target Organism A. rhizogenes

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 14 µg/mL

Target

Target Organism C. michiganensis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 13 µg/mL

Target

Target Organism C. flaccumfaciens

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 2 µg/mL

Target

Target Organism F. oxysporum

Source & Reference

Database Source DRAMP

Other

Evidence Text

C50 20 ug/ml), C. michiganensis (IC50 14 ug/ml), C. flaccumfaciens (IC50 13 ug/ml), fungi F. oxysporum (IC50 2 ug/ml), and G. candidum (IC50 2 ug/ml). Updated 7/2021

Evidence 21 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiparasitic

Activity Measurement 2 µg/mL

Target

Target Organism G. candidum

Source & Reference

Database Source DRAMP

Other

Evidence Text

IC50 14 ug/ml), C. flaccumfaciens (IC50 13 ug/ml), fungi F. oxysporum (IC50 2 ug/ml), and G. candidum (IC50 2 ug/ml). Updated 7/2021

Evidence 22 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 11 µg/mL

Target

Target Organism E. carotovora

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against bacteria E. carotovora (IC50 11 ug/ml), A. radiobacter (IC50 15 ug/ml), A. rhizogenes (IC50 20 ug/ml), C. michiganensis (IC50 14

Evidence 23 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 15 µg/mL

Target

Target Organism A. radiobacter

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against bacteria E. carotovora (IC50 11 ug/ml), A. radiobacter (IC50 15 ug/ml), A. rhizogenes (IC50 20 ug/ml), C. michiganensis (IC50 14 ug/ml), C. flaccumfaciens (IC50

Evidence 24 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 20 µg/mL

Target

Target Organism A. rhizogenes

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 14 µg/mL

Target

Target Organism C. michiganensis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 13 µg/mL

Target

Target Organism C. flaccumfaciens

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism F. oxysporum

Source & Reference

Database Source DRAMP

Other

Evidence Text

C50 20 ug/ml), C. michiganensis (IC50 14 ug/ml), C. flaccumfaciens (IC50 13 ug/ml), fungi F. oxysporum (IC50 2 ug/ml), and G. candidum (IC50 2 ug/ml). Updated 7/2021

Evidence 28 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism G. candidum

Source & Reference

Database Source DRAMP

Other

Evidence Text

IC50 14 ug/ml), C. flaccumfaciens (IC50 13 ug/ml), fungi F. oxysporum (IC50 2 ug/ml), and G. candidum (IC50 2 ug/ml). Updated 7/2021