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Peptide record

TPDB13782

Antibacterial Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB13782
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 39-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
EPRWKVFKKIEKMGRNIRDGIIKAGPAVAVLGDAKALGK
Physicochemical Analysis
C193H327N57O49S1
CQHSTY
K
4262.13
10.89
10
4
17
+6
11.02
-0.321
95.13
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
5500
129.04
1
Residue Composition
number
5
A
3
R
1
N
2
D
0
C
2
E
0
Q
5
G
0
H
4
I
2
L
7
K
1
M
1
F
2
P
0
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 5 R: 3 N: 1 D: 2 C: 0 E: 2 Q: 0 G: 5 H: 0 I: 4 L: 2 K: 7 M: 1 F: 1 P: 2 S: 0 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
39
C193H327N57O49S1
4262.13
10.89
+6
11.02
-0.321
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
29.3 µM

Target

Pseudomonas aeruginosa ATCC700603

Source & Reference

NA

Other

Active against Salmonella ATCC13076 (MIC 2.9 uM), E. coli ATCC25922 (1.8 uM), P. aeruginosa ATCC700603 (MIC 29.3 uM), and K. pneumoniae ATCC27853 (MIC 3.7 uM), but did not inhibit B.cereus or S.aureus at 25
Evidence 2 Activity

Activity

MIC
Antibacterial
3.7 µM

Target

Klebsiella pneumoniae ATCC27853

Source & Reference

NA

Other

076 (MIC 2.9 uM), E. coli ATCC25922 (1.8 uM), P. aeruginosa ATCC700603 (MIC 29.3 uM), and K. pneumoniae ATCC27853 (MIC 3.7 uM), but did not inhibit B.cereus or S.aureus at 250.00 ug/mL (>58 uM).
Evidence 3 Activity

Activity

14.47±1.03% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
14.47±1.03% Hemolysis | 500 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Identification and characteristics of a novel cecropin from the armyworm, Mythimna separata. | BMC Microbiol | 2020
Evidence 4 Activity

Activity

5% Hemolysis
Toxicity
300 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 300 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Identification and characteristics of a novel cecropin from the armyworm, Mythimna separata. | BMC Microbiol | 2020
Evidence 5 Activity

Activity

<10% Killing
Toxicity
500 µg/mL
Cytotoxic
<10% Killing | 500 | µg/mL | target cell: Swine testis cells ST

Target

Swine testis cells ST

Source & Reference

NA
DBAASP
Identification and characteristics of a novel cecropin from the armyworm, Mythimna separata. | BMC Microbiol | 2020