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Peptide record

TPDB13771

Antibacterial Toxicity standard

38 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB13771

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 38-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

GYGCNIFGGNDYRCHRHCKSIRGYKGGYCKLGGICKCY

FASTA

>TPDB13771|Antibacterial;Toxicity|length=38
GYGCNIFGGNDYRCHRHCKSIRGYKGGYCKLGGICKCY

Formula C183H277N57O49S6

Absent Amino Acids AEQMPTWV

Common Amino Acids G

Mass 4251.92

PI 9.11

Basic Residues 9

Acidic Residues 1

Hydrophobic Residues 10

Net Charge +6

Boman Index 1.84

Hydrophobicity -0.574

Aliphatic Index 41.05

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 7825

Absorbance 280nm 184.03

Polar Residues 14

number

Amino Acid Distribution

A: 0 R: 3 N: 2 D: 1 C: 6 E: 0 Q: 0 G: 9 H: 2 I: 3 L: 1 K: 4 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 5 V: 0

Length

Formula

C183H277N57O49S6

Mass

4251.92

9.11

Net Charge

Boman Index

1.84

Hydrophobicity

-0.574

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2-4 µM

Target

Target Organism Staphylococcus aureus BNCC 337371 or BNCC 340652 or ATCC 6538

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 2-4 uM), B. cereus BNCC 103930 (MIC 4 uM), B. subtilis BNCC 109047 (MIC 4 uM), M. luteus BNCC 102

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism B. cereus BNCC 103930

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram+ S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 2-4 uM), B. cereus BNCC 103930 (MIC 4 uM), B. subtilis BNCC 109047 (MIC 4 uM), M. luteus BNCC 102589 (MIC 2 uM), S. epidermidis ATC

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism B. subtilis BNCC 109047

Source & Reference

Database Source NA

Other

Evidence Text

s BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 2-4 uM), B. cereus BNCC 103930 (MIC 4 uM), B. subtilis BNCC 109047 (MIC 4 uM), M. luteus BNCC 102589 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 2 uM), E. faecalis clin

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism M. luteus BNCC 102589

Source & Reference

Database Source NA

Other

Evidence Text

6538 (MIC 2-4 uM), B. cereus BNCC 103930 (MIC 4 uM), B. subtilis BNCC 109047 (MIC 4 uM), M. luteus BNCC 102589 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 2 uM), E. faecalis clinical (MIC 2 uM), E. faecium (MIC 1

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source NA

Other

Evidence Text

103930 (MIC 4 uM), B. subtilis BNCC 109047 (MIC 4 uM), M. luteus BNCC 102589 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 2 uM), E. faecalis clinical (MIC 2 uM), E. faecium (MIC 1 uM) anti-VRE, Gram- E.coli ATCC 8739

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µM

Target

Target Organism Enterococcus faecalis clinical

Source & Reference

Database Source NA

Other

Evidence Text

09047 (MIC 4 uM), M. luteus BNCC 102589 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 2 uM), E. faecalis clinical (MIC 2 uM), E. faecium (MIC 1 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens AT

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µM

Target

Target Organism E. faecium

Source & Reference

Database Source NA

Other

Evidence Text

102589 (MIC 2 uM), S. epidermidis ATCC 12228 (MIC 2 uM), E. faecalis clinical (MIC 2 uM), E. faecium (MIC 1 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens ATCC 14756 (MIC >64 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >64 µM

Target

Target Organism S.marcescens ATCC 14756

Source & Reference

Database Source NA

Other

Evidence Text

ical (MIC 2 uM), E. faecium (MIC 1 uM) anti-VRE, Gram- E.coli ATCC 8739 (MIC> 64 uM), and S.marcescens ATCC 14756 (MIC >64 uM).

Evidence 9 Activity

Activity

Activity Endpoint 13% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

13% Hemolysis | 50 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The second N-terminal aromatic residue of the fungal defensin, blapersin, of Blastomyces percursus is essential for its antibacterial activity. | Peptides | 2020

Evidence 10 Activity

Activity

Activity Endpoint 3% Killing

Detail Source Activity Toxicity

Activity Measurement 50 µM

Toxicity Type Cytotoxic

Toxicity Raw

3% Killing | 50 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Target Cell Human embryonic kidney HEK293 cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The second N-terminal aromatic residue of the fungal defensin, blapersin, of Blastomyces percursus is essential for its antibacterial activity. | Peptides | 2020