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Peptide record

TPDB13763

Antibacterial Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB13763
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 38-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GWGCNIFGGNDYRCHRHCKSIRGYKGGYCKLGGICKCY
Physicochemical Analysis
C185H278N58O48S6
AEQMPTV
G
4274.96
9.14
9
1
10
+6
0.93
-0.563
41.05
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11835
276.84
13
Residue Composition
number
0
A
3
R
2
N
1
D
6
C
0
E
0
Q
9
G
2
H
3
I
1
L
4
K
0
M
1
F
0
P
1
S
0
T
1
W
4
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 1 C: 6 E: 0 Q: 0 G: 9 H: 2 I: 3 L: 1 K: 4 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 4 V: 0
Chemical Descriptors
38
C185H278N58O48S6
4274.96
9.14
+6
0.93
-0.563
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

E. faecium VRE clinical

Source & Reference

NA

Other

Active against E. faecium VRE clinical (MIC 4-8 uM) anti-VRE, S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 8 uM), S. epidermidis AT
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus BNCC 337371 or BNCC 340652 or ATCC 6538

Source & Reference

NA

Other

Active against E. faecium VRE clinical (MIC 4-8 uM) anti-VRE, S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 8 uM), S. epidermidis ATCC 12228 (MIC 4 uM), B. cereus BNCC 103930 (MIC16 uM), B. subtilis BNCC
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

NA

Other

ical (MIC 4-8 uM) anti-VRE, S. aureus BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 8 uM), S. epidermidis ATCC 12228 (MIC 4 uM), B. cereus BNCC 103930 (MIC16 uM), B. subtilis BNCC 109047 (MIC 16 uM), M. luteus BNCC 10
Evidence 4 Activity

Activity

MIC
Antibacterial
16 µM

Target

B. cereus BNCC 103930

Source & Reference

NA

Other

BNCC 337371 or BNCC 340652 or ATCC 6538 (MIC 8 uM), S. epidermidis ATCC 12228 (MIC 4 uM), B. cereus BNCC 103930 (MIC16 uM), B. subtilis BNCC 109047 (MIC 16 uM), M. luteus BNCC 102589 (MIC 16 uM), E. faecalis clin
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µM

Target

B. subtilis BNCC 109047

Source & Reference

NA

Other

6538 (MIC 8 uM), S. epidermidis ATCC 12228 (MIC 4 uM), B. cereus BNCC 103930 (MIC16 uM), B. subtilis BNCC 109047 (MIC 16 uM), M. luteus BNCC 102589 (MIC 16 uM), E. faecalis clinical (MIC 16 uM), Gram- E. coli (MIC>
Evidence 6 Activity

Activity

MIC
Antibacterial
16 µM

Target

M. luteus BNCC 102589

Source & Reference

NA

Other

12228 (MIC 4 uM), B. cereus BNCC 103930 (MIC16 uM), B. subtilis BNCC 109047 (MIC 16 uM), M. luteus BNCC 102589 (MIC 16 uM), E. faecalis clinical (MIC 16 uM), Gram- E. coli (MIC>64 uM) and S.marcescens ATCC 14756
Evidence 7 Activity

Activity

MIC
Antibacterial
16 µM

Target

Enterococcus faecalis clinical

Source & Reference

NA

Other

03930 (MIC16 uM), B. subtilis BNCC 109047 (MIC 16 uM), M. luteus BNCC 102589 (MIC 16 uM), E. faecalis clinical (MIC 16 uM), Gram- E. coli (MIC>64 uM) and S.marcescens ATCC 14756 (MIC > 64 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
>64 µM

Target

Escherichia coli

Source & Reference

NA

Other

7 (MIC 16 uM), M. luteus BNCC 102589 (MIC 16 uM), E. faecalis clinical (MIC 16 uM), Gram- E. coli (MIC>64 uM) and S.marcescens ATCC 14756 (MIC > 64 uM).
Evidence 9 Activity

Activity

15% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
15% Hemolysis | 50 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
The second N-terminal aromatic residue of the fungal defensin, blapersin, of Blastomyces percursus is essential for its antibacterial activity. | Peptides | 2020
Evidence 10 Activity

Activity

9% Killing
Toxicity
50 µM
Cytotoxic
9% Killing | 50 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
The second N-terminal aromatic residue of the fungal defensin, blapersin, of Blastomyces percursus is essential for its antibacterial activity. | Peptides | 2020
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
128±3 µM
Hemolytic Cytotoxic
50% Hemolysis | 128±3 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
The second N-terminal aromatic residue of the fungal defensin, blapersin, of Blastomyces percursus is essential for its antibacterial activity. | Peptides | 2020