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Peptide record

TPDB13747

Antibacterial Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13747
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GLLSRLRDRLSDRGRRLGEKIERIGQKIKDLSERFQS
Physicochemical Analysis
C186H326N66O56
ANCHMPTWYV
R
4383.04
11.65
11
6
10
+5
15.50
-1.119
94.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
6
Residue Composition
number
0
A
8
R
0
N
3
D
0
C
3
E
2
Q
4
G
0
H
3
I
6
L
3
K
0
M
1
F
0
P
4
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 3 C: 0 E: 3 Q: 2 G: 4 H: 0 I: 3 L: 6 K: 3 M: 0 F: 1 P: 0 S: 4 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
37
C186H326N66O56
4383.04
11.65
+5
15.50
-1.119
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.049 µg/mL

Target

S. aureusATCC25923

Source & Reference

NA

Other

Active against Gram+ S. aureusATCC25923 (MIC 0.049 ug/ml), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21533 (MIC 62.5 ug/ml), B. subti
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Staphylococcus epidermidis LY8

Source & Reference

NA

Other

Active against Gram+ S. aureusATCC25923 (MIC 0.049 ug/ml), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21533 (MIC 62.5 ug/ml), B. subtilis CICC24434 (MIC 0.78 ug/ml), Gra
Evidence 3 Activity

Activity

MIC
Antibacterial
62.5 µg/mL

Target

L. monocytogenes CICC21533

Source & Reference

NA

Other

ve against Gram+ S. aureusATCC25923 (MIC 0.049 ug/ml), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21533 (MIC 62.5 ug/ml), B. subtilis CICC24434 (MIC 0.78 ug/ml), Gram- S. choleraesuis C78-1 (MIC 0.78 ug/ml), S.
Evidence 4 Activity

Activity

MIC
Antibacterial
0.78 µg/mL

Target

B. subtilis CICC24434

Source & Reference

NA

Other

9 ug/ml), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21533 (MIC 62.5 ug/ml), B. subtilis CICC24434 (MIC 0.78 ug/ml), Gram- S. choleraesuis C78-1 (MIC 0.78 ug/ml), S. typhimurium SL1344 (MIC 1.56 ug/ml), P.
Evidence 5 Activity

Activity

MIC
Antibacterial
0.78 µg/mL

Target

S. choleraesuis C78-1

Source & Reference

NA

Other

. monocytogenes CICC21533 (MIC 62.5 ug/ml), B. subtilis CICC24434 (MIC 0.78 ug/ml), Gram- S. choleraesuis C78-1 (MIC 0.78 ug/ml), S. typhimurium SL1344 (MIC 1.56 ug/ml), P. avium C48-3 (MIC 3.125 ug/ml), E. coli CICC10
Evidence 6 Activity

Activity

MIC
Antibacterial
1.56 µg/mL

Target

S. typhimurium SL1344

Source & Reference

NA

Other

l), B. subtilis CICC24434 (MIC 0.78 ug/ml), Gram- S. choleraesuis C78-1 (MIC 0.78 ug/ml), S. typhimurium SL1344 (MIC 1.56 ug/ml), P. avium C48-3 (MIC 3.125 ug/ml), E. coli CICC10004 (MIC 12.5 ug/ml), and S. flexneri CI
Evidence 7 Activity

Activity

MIC
Antibacterial
3.125 µg/mL

Target

P. avium C48-3

Source & Reference

NA

Other

l), Gram- S. choleraesuis C78-1 (MIC 0.78 ug/ml), S. typhimurium SL1344 (MIC 1.56 ug/ml), P. avium C48-3 (MIC 3.125 ug/ml), E. coli CICC10004 (MIC 12.5 ug/ml), and S. flexneri CICC21534 (MIC 75 ug/ml).
Evidence 8 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Escherichia coli CICC10004

Source & Reference

NA

Other

IC 0.78 ug/ml), S. typhimurium SL1344 (MIC 1.56 ug/ml), P. avium C48-3 (MIC 3.125 ug/ml), E. coli CICC10004 (MIC 12.5 ug/ml), and S. flexneri CICC21534 (MIC 75 ug/ml).
Evidence 9 Activity

Activity

MIC
Antibacterial
75 µg/mL

Target

S. flexneri CICC21534

Source & Reference

NA

Other

IC 1.56 ug/ml), P. avium C48-3 (MIC 3.125 ug/ml), E. coli CICC10004 (MIC 12.5 ug/ml), and S. flexneri CICC21534 (MIC 75 ug/ml).
Evidence 10 Activity

Activity

<5% Hemolysis
Toxicity
1000 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 1000 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptide PMAP-37 Analogs: Increasing the Positive Charge to Enhance the Antibacterial Activity of PMAP-37. | J Pept Sci | 2019