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Peptide record

TPDB13727

Antibacterial Antifungal Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB13727
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse CAFPdb
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWKFLKKIEKVGRKVRDGVIKAGPAVGVVGQATSIYK
Physicochemical Analysis
C188H317N55O46
NCHM
K
4083.93
11.23
10
2
16
+8
8.46
-0.214
97.30
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
6990
171.16
4
Residue Composition
number
3
A
3
R
0
N
1
D
0
C
1
E
1
Q
5
G
0
H
3
I
1
L
7
K
0
M
1
F
1
P
1
S
1
T
1
W
1
Y
6
V
Amino Acid Distribution
A: 3 R: 3 N: 0 D: 1 C: 0 E: 1 Q: 1 G: 5 H: 0 I: 3 L: 1 K: 7 M: 0 F: 1 P: 1 S: 1 T: 1 W: 1 Y: 1 V: 6
Chemical Descriptors
37
C188H317N55O46
4083.93
11.23
+8
8.46
-0.214
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.1 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli (MIC 2.1 ug/ml), S.aureus (MIC>100 ug/ml), B. subtilis (MIC 50 uM), C. albicans (MIC 72.5 ug/ml), P. aeru
Evidence 2 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

S.aureus

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 2.1 ug/ml), S.aureus (MIC>100 ug/ml), B. subtilis (MIC 50 uM), C. albicans (MIC 72.5 ug/ml), P. aeruginosa (MIC 5 ug/ml), and
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 2.1 ug/ml), S.aureus (MIC>100 ug/ml), B. subtilis (MIC 50 uM), C. albicans (MIC 72.5 ug/ml), P. aeruginosa (MIC 5 ug/ml), and K. pneumoniae (MIC 4.3 ug
Evidence 4 Activity

Activity

MIC
Antibacterial
72.5 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

ctive against E. coli (MIC 2.1 ug/ml), S.aureus (MIC>100 ug/ml), B. subtilis (MIC 50 uM), C. albicans (MIC 72.5 ug/ml), P. aeruginosa (MIC 5 ug/ml), and K. pneumoniae (MIC 4.3 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

ug/ml), S.aureus (MIC>100 ug/ml), B. subtilis (MIC 50 uM), C. albicans (MIC 72.5 ug/ml), P. aeruginosa (MIC 5 ug/ml), and K. pneumoniae (MIC 4.3 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
4.3 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

, B. subtilis (MIC 50 uM), C. albicans (MIC 72.5 ug/ml), P. aeruginosa (MIC 5 ug/ml), and K. pneumoniae (MIC 4.3 ug/ml).
Evidence 7 Activity

Activity

MIC
Antifungal
2.1 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E. coli (MIC 2.1 ug/ml), S.aureus (MIC>100 ug/ml), B. subtilis (MIC 50 uM), C. albicans (MIC 72.5 ug/ml), P. aeru
Evidence 8 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

S.aureus

Source & Reference

dbAMP DRAMP CAFPdb

Other

active against E. coli (MIC 2.1 ug/ml), S.aureus (MIC>100 ug/ml), B. subtilis (MIC 50 uM), C. albicans (MIC 72.5 ug/ml), P. aeruginosa (MIC 5 ug/ml), and
Evidence 9 Activity

Activity

MIC
Antifungal
50 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb

Other

active against E. coli (MIC 2.1 ug/ml), S.aureus (MIC>100 ug/ml), B. subtilis (MIC 50 uM), C. albicans (MIC 72.5 ug/ml), P. aeruginosa (MIC 5 ug/ml), and K. pneumoniae (MIC 4.3 ug
Evidence 10 Activity

Activity

MIC
Antifungal
72.5 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb

Other

ctive against E. coli (MIC 2.1 ug/ml), S.aureus (MIC>100 ug/ml), B. subtilis (MIC 50 uM), C. albicans (MIC 72.5 ug/ml), P. aeruginosa (MIC 5 ug/ml), and K. pneumoniae (MIC 4.3 ug/ml).
Evidence 11 Activity

Activity

MIC
Antifungal
5 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb

Other

ug/ml), S.aureus (MIC>100 ug/ml), B. subtilis (MIC 50 uM), C. albicans (MIC 72.5 ug/ml), P. aeruginosa (MIC 5 ug/ml), and K. pneumoniae (MIC 4.3 ug/ml).
Evidence 12 Activity

Activity

MIC
Antifungal
4.3 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb

Other

, B. subtilis (MIC 50 uM), C. albicans (MIC 72.5 ug/ml), P. aeruginosa (MIC 5 ug/ml), and K. pneumoniae (MIC 4.3 ug/ml).
Evidence 13 Activity

Activity

0% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 200 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Identification and screening of potent antimicrobial peptides in arthropod genomes. | Peptides | 2018
Evidence 14 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.29501691] 0% haemolysis at 10 µg/ml, 0% haemolysis at 25 µg/ml, 0% haemolysis at 50 µg/ml, 0% haemolysis at 100 µg/ml, 0% haemolysis at 200 µg/ml against sheep red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2018 May 103:26-30. doi: 10.1016/j.peptides.2018.01.017.