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Peptide record

TPDB13725

Antibacterial Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB13725
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GLLSRLRDFLSDRGRRLGEKIERIGQKIKDLSERFQS
Physicochemical Analysis
C189H323N63O56
ANCHMPTWYV
R
4374.03
11.26
10
6
11
+4
13.56
-0.922
94.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
6
Residue Composition
number
0
A
7
R
0
N
3
D
0
C
3
E
2
Q
4
G
0
H
3
I
6
L
3
K
0
M
2
F
0
P
4
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 3 C: 0 E: 3 Q: 2 G: 4 H: 0 I: 3 L: 6 K: 3 M: 0 F: 2 P: 0 S: 4 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
37
C189H323N63O56
4374.03
11.26
+4
13.56
-0.922
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.025 µg/mL

Target

S. aureusATCC25923

Source & Reference

NA

Other

Active against Gram+ S. aureusATCC25923 (MIC 0.025 ug/ml), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21533 (MIC 31.25 ug/ml), B. subt
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Staphylococcus epidermidis LY8

Source & Reference

NA

Other

Active against Gram+ S. aureusATCC25923 (MIC 0.025 ug/ml), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21533 (MIC 31.25 ug/ml), B. subtilis CICC24434 (MIC 0.78 ug/ml), Gr
Evidence 3 Activity

Activity

MIC
Antibacterial
31.25 µg/mL

Target

L. monocytogenes CICC21533

Source & Reference

NA

Other

ve against Gram+ S. aureusATCC25923 (MIC 0.025 ug/ml), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21533 (MIC 31.25 ug/ml), B. subtilis CICC24434 (MIC 0.78 ug/ml), Gram- S. choleraesuis C78-1 (MIC 0.78 ug/ml), S.
Evidence 4 Activity

Activity

MIC
Antibacterial
0.78 µg/mL

Target

B. subtilis CICC24434

Source & Reference

NA

Other

ug/ml), S. epidermidis LY8 (MIC 25 ug/ml), L. monocytogenes CICC21533 (MIC 31.25 ug/ml), B. subtilis CICC24434 (MIC 0.78 ug/ml), Gram- S. choleraesuis C78-1 (MIC 0.78 ug/ml), S. typhimurium SL1344 (MIC 0.78 ug/ml), P.
Evidence 5 Activity

Activity

MIC
Antibacterial
0.78 µg/mL

Target

S. choleraesuis C78-1

Source & Reference

NA

Other

monocytogenes CICC21533 (MIC 31.25 ug/ml), B. subtilis CICC24434 (MIC 0.78 ug/ml), Gram- S. choleraesuis C78-1 (MIC 0.78 ug/ml), S. typhimurium SL1344 (MIC 0.78 ug/ml), P. avium C48-3 (MIC 1.56 ug/ml), and E. coli CIC
Evidence 6 Activity

Activity

MIC
Antibacterial
0.78 µg/mL

Target

S. typhimurium SL1344

Source & Reference

NA

Other

l), B. subtilis CICC24434 (MIC 0.78 ug/ml), Gram- S. choleraesuis C78-1 (MIC 0.78 ug/ml), S. typhimurium SL1344 (MIC 0.78 ug/ml), P. avium C48-3 (MIC 1.56 ug/ml), and E. coli CICC10004 (MIC 6.25 ug/ml).
Evidence 7 Activity

Activity

MIC
Antibacterial
1.56 µg/mL

Target

P. avium C48-3

Source & Reference

NA

Other

l), Gram- S. choleraesuis C78-1 (MIC 0.78 ug/ml), S. typhimurium SL1344 (MIC 0.78 ug/ml), P. avium C48-3 (MIC 1.56 ug/ml), and E. coli CICC10004 (MIC 6.25 ug/ml).
Evidence 8 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

Escherichia coli CICC10004

Source & Reference

NA

Other

0.78 ug/ml), S. typhimurium SL1344 (MIC 0.78 ug/ml), P. avium C48-3 (MIC 1.56 ug/ml), and E. coli CICC10004 (MIC 6.25 ug/ml).
Evidence 9 Activity

Activity

<5% Hemolysis
Toxicity
1000 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 1000 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptide PMAP-37 Analogs: Increasing the Positive Charge to Enhance the Antibacterial Activity of PMAP-37. | J Pept Sci | 2019
Evidence 10 Activity

Activity

5% Hemolysis
Toxicity
1280 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 1280 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Enhancing the antibacterial activity of antimicrobial peptide PMAP-37(F34-R) by cholesterol modification. | BMC Vet Res | 2020
Evidence 11 Activity

Activity

18% Killing
Toxicity
1280 µg/mL
Cytotoxic
18% Killing | 1280 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Enhancing the antibacterial activity of antimicrobial peptide PMAP-37(F34-R) by cholesterol modification. | BMC Vet Res | 2020
Evidence 12 Activity

Activity

<10% Killing
Toxicity
320 µg/mL
Cytotoxic
<10% Killing | 320 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Enhancing the antibacterial activity of antimicrobial peptide PMAP-37(F34-R) by cholesterol modification. | BMC Vet Res | 2020