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Peptide record

TPDB13723

Antibacterial Antifungal Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB13723
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKIFKKIEKVGRNVRDGIIKAGPAVQVVGQATSIAK
Physicochemical Analysis
C184H314N54O47
CHLMY
K
4034.85
11.23
9
2
16
+7
9.28
-0.159
102.70
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
136.31
5
Residue Composition
number
4
A
2
R
1
N
1
D
0
C
1
E
2
Q
4
G
0
H
5
I
0
L
7
K
0
M
1
F
1
P
1
S
1
T
1
W
0
Y
5
V
Amino Acid Distribution
A: 4 R: 2 N: 1 D: 1 C: 0 E: 1 Q: 2 G: 4 H: 0 I: 5 L: 0 K: 7 M: 0 F: 1 P: 1 S: 1 T: 1 W: 1 Y: 0 V: 5
Chemical Descriptors
37
C184H314N54O47
4034.85
11.23
+7
9.28
-0.159
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.9 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli (MIC 4.9 ug/ml), S.aureus (MIC>200 ug/ml), B.subtilis (MIC 131.3 uM), C.albicans (MIC >200 ug/ml), P. aer
Evidence 2 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

S.aureus

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 4.9 ug/ml), S.aureus (MIC>200 ug/ml), B.subtilis (MIC 131.3 uM), C.albicans (MIC >200 ug/ml), P. aeruginosa (MIC 7 ug/ml), and
Evidence 3 Activity

Activity

MIC
Antibacterial
131.3 µM

Target

B.subtilis

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 4.9 ug/ml), S.aureus (MIC>200 ug/ml), B.subtilis (MIC 131.3 uM), C.albicans (MIC >200 ug/ml), P. aeruginosa (MIC 7 ug/ml), and K. pneumoniae (MIC 16.2 ug
Evidence 4 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

C.albicans

Source & Reference

dbAMP DRAMP

Other

ive against E. coli (MIC 4.9 ug/ml), S.aureus (MIC>200 ug/ml), B.subtilis (MIC 131.3 uM), C.albicans (MIC >200 ug/ml), P. aeruginosa (MIC 7 ug/ml), and K. pneumoniae (MIC 16.2 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
7 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

ug/ml), S.aureus (MIC>200 ug/ml), B.subtilis (MIC 131.3 uM), C.albicans (MIC >200 ug/ml), P. aeruginosa (MIC 7 ug/ml), and K. pneumoniae (MIC 16.2 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
16.2 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

B.subtilis (MIC 131.3 uM), C.albicans (MIC >200 ug/ml), P. aeruginosa (MIC 7 ug/ml), and K. pneumoniae (MIC 16.2 ug/ml).
Evidence 7 Activity

Activity

MIC
Antifungal
4.9 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E. coli (MIC 4.9 ug/ml), S.aureus (MIC>200 ug/ml), B.subtilis (MIC 131.3 uM), C.albicans (MIC >200 ug/ml), P. aer
Evidence 8 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

S.aureus

Source & Reference

dbAMP DRAMP CAFPdb

Other

active against E. coli (MIC 4.9 ug/ml), S.aureus (MIC>200 ug/ml), B.subtilis (MIC 131.3 uM), C.albicans (MIC >200 ug/ml), P. aeruginosa (MIC 7 ug/ml), and
Evidence 9 Activity

Activity

MIC
Antifungal
131.3 µM

Target

B.subtilis

Source & Reference

dbAMP DRAMP CAFPdb

Other

active against E. coli (MIC 4.9 ug/ml), S.aureus (MIC>200 ug/ml), B.subtilis (MIC 131.3 uM), C.albicans (MIC >200 ug/ml), P. aeruginosa (MIC 7 ug/ml), and K. pneumoniae (MIC 16.2 ug
Evidence 10 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

C.albicans

Source & Reference

dbAMP DRAMP CAFPdb

Other

ive against E. coli (MIC 4.9 ug/ml), S.aureus (MIC>200 ug/ml), B.subtilis (MIC 131.3 uM), C.albicans (MIC >200 ug/ml), P. aeruginosa (MIC 7 ug/ml), and K. pneumoniae (MIC 16.2 ug/ml).
Evidence 11 Activity

Activity

MIC
Antifungal
7 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb

Other

ug/ml), S.aureus (MIC>200 ug/ml), B.subtilis (MIC 131.3 uM), C.albicans (MIC >200 ug/ml), P. aeruginosa (MIC 7 ug/ml), and K. pneumoniae (MIC 16.2 ug/ml).
Evidence 12 Activity

Activity

MIC
Antifungal
16.2 µg/mL

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb

Other

B.subtilis (MIC 131.3 uM), C.albicans (MIC >200 ug/ml), P. aeruginosa (MIC 7 ug/ml), and K. pneumoniae (MIC 16.2 ug/ml).
Evidence 13 Activity

Activity

0% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 200 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Identification and screening of potent antimicrobial peptides in arthropod genomes. | Peptides | 2018
Evidence 14 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.29501691] 0% haemolysis at 10 µg/ml, 0% haemolysis at 25 µg/ml, 0% haemolysis at 50 µg/ml, 0% haemolysis at 100 µg/ml, 0% haemolysis at 200 µg/ml against sheep red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2018 May 103:26-30. doi: 10.1016/j.peptides.2018.01.017.