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Peptide record

TPDB13710

Antibacterial Hemolysis Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB13710
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 36-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
GRFRRLRKKTRKRLKKIGKVLKWIWWIVGSIPLGCG
Physicochemical Analysis
C203H342N64O39S1
ANDEQHMY
K
4335.41
12.72
13
0
14
+13
2.30
-0.422
102.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
16500
380.59
3
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
0
Q
5
G
0
H
4
I
4
L
7
K
0
M
1
F
1
P
1
S
1
T
3
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 5 H: 0 I: 4 L: 4 K: 7 M: 0 F: 1 P: 1 S: 1 T: 1 W: 3 Y: 0 V: 2
Chemical Descriptors
36
C203H342N64O39S1
4335.41
12.72
+13
2.30
-0.422
Evidence Records 8 records
Evidence 1 Activity

Activity

12% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
12% Hemolysis | 128 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of the antibacterial peptide PMAP-36 and its analogues. | Microb Pathog | 2019
Evidence 2 Activity

Activity

26% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
26% Hemolysis | 512 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of the antibacterial peptide PMAP-36 and its analogues. | Microb Pathog | 2019
Evidence 3 Activity

Activity

30% Killing
Toxicity
512 µg/mL
Cytotoxic
30% Killing | 512 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Antimicrobial activity of the antibacterial peptide PMAP-36 and its analogues. | Microb Pathog | 2019
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 80 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
N-terminal Myristoylation Enhanced the Antimicrobial Activity of Antimicrobial Peptide PMAP-36PW | Front Cell Infect Microbiol | 2020
Evidence 5 Activity

Activity

28% Hemolysis
Toxicity
640 µg/mL
Hemolytic Cytotoxic
28% Hemolysis | 640 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
N-terminal Myristoylation Enhanced the Antimicrobial Activity of Antimicrobial Peptide PMAP-36PW | Front Cell Infect Microbiol | 2020
Evidence 6 Activity

Activity

18% Killing
Toxicity
80 µg/mL
Cytotoxic
18% Killing | 80 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
N-terminal Myristoylation Enhanced the Antimicrobial Activity of Antimicrobial Peptide PMAP-36PW | Front Cell Infect Microbiol | 2020
Evidence 7 Activity

Activity

28% Killing
Toxicity
640 µg/mL
Cytotoxic
28% Killing | 640 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
N-terminal Myristoylation Enhanced the Antimicrobial Activity of Antimicrobial Peptide PMAP-36PW | Front Cell Infect Microbiol | 2020
Evidence 8 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis