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Peptide record

TPDB13701

Antibacterial Antifungal Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB13701
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
PPPVIKFNRPFLMWIVERDTRSILFMGKIVNPKAP
Physicochemical Analysis
C194H308N50O44S2
CQHY
P
4109.01
11.46
6
2
16
+4
4.45
0.017
94.57
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
5500
133.85
4
Residue Composition
number
1
A
3
R
2
N
1
D
0
C
1
E
0
Q
1
G
0
H
4
I
2
L
3
K
2
M
3
F
6
P
1
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 3 N: 2 D: 1 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 4 L: 2 K: 3 M: 2 F: 3 P: 6 S: 1 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
35
C194H308N50O44S2
4109.01
11.46
+4
4.45
0.017
Evidence Records 10 records
Evidence 1 Activity

Activity

EC50
Antibacterial
0.0986 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (EC50 0.0986 uM), P. aeruginosa (EC50 4.35 uM), B. cereus (EC50 0.770 uM), and S. aureus (EC50 1.36 uM).
Evidence 2 Activity

Activity

EC50
Antibacterial
4.35 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (EC50 0.0986 uM), P. aeruginosa (EC50 4.35 uM), B. cereus (EC50 0.770 uM), and S. aureus (EC50 1.36 uM).
Evidence 3 Activity

Activity

EC50
Antibacterial
0.770 µM

Target

B. cereus

Source & Reference

dbAMP DRAMP

Other

Active against E. coli (EC50 0.0986 uM), P. aeruginosa (EC50 4.35 uM), B. cereus (EC50 0.770 uM), and S. aureus (EC50 1.36 uM).
Evidence 4 Activity

Activity

EC50
Antibacterial
1.36 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

st E. coli (EC50 0.0986 uM), P. aeruginosa (EC50 4.35 uM), B. cereus (EC50 0.770 uM), and S. aureus (EC50 1.36 uM).
Evidence 5 Activity

Activity

EC50
Antifungal
0.0986 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (EC50 0.0986 uM), P. aeruginosa (EC50 4.35 uM), B. cereus (EC50 0.770 uM), and S. aureus (EC50 1.36 uM).
Evidence 6 Activity

Activity

EC50
Antifungal
4.35 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli (EC50 0.0986 uM), P. aeruginosa (EC50 4.35 uM), B. cereus (EC50 0.770 uM), and S. aureus (EC50 1.36 uM).
Evidence 7 Activity

Activity

EC50
Antifungal
0.770 µM

Target

B. cereus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli (EC50 0.0986 uM), P. aeruginosa (EC50 4.35 uM), B. cereus (EC50 0.770 uM), and S. aureus (EC50 1.36 uM).
Evidence 8 Activity

Activity

EC50
Antifungal
1.36 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

st E. coli (EC50 0.0986 uM), P. aeruginosa (EC50 4.35 uM), B. cereus (EC50 0.770 uM), and S. aureus (EC50 1.36 uM).
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii. | BMC Microbiol | 2016
Evidence 10 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.27542832] Not hemolytic to sheep red blood cells. | Cytotoxicity: [Ref.27542832] The cell proliferation of A549 human lung epithelial cells is 170%, 180%, 182%, 180% and 180% at peptide concentrations of 1 µg/ml, 10 µg/ml, 25 µg/ml, 50 µg/ml, 100 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
BMC Microbiol. 2016 Aug 19 16(1):189.