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Peptide record

TPDB13690

Antibacterial Antifungal Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB13690
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RECRIGNGQCKNQCHENEIRIAYCIRPGTHCCLQQ
Physicochemical Analysis
C164H269N59O51S6
DMFSWV
C
4075.66
8.02
7
3
7
+2
12.06
-0.843
58.57
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1865
45.76
15
Residue Composition
number
1
A
4
R
3
N
0
D
6
C
3
E
4
Q
3
G
2
H
4
I
1
L
1
K
0
M
0
F
1
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 3 D: 0 C: 6 E: 3 Q: 4 G: 3 H: 2 I: 4 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
35
C164H269N59O51S6
4075.66
8.02
+2
12.06
-0.843
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

Active against S. aureus ATCC 25923 (MIC 25 uM), E. coli ATCC 25922 (25 uM), M. tuberculosis H37Rv (MIC 11.8 uM), and M. tuberculosis MDR
Evidence 2 Activity

Activity

MIC
Antibacterial
11.8 µM

Target

M. tuberculosis H37Rv

Source & Reference

NA

Other

Active against S. aureus ATCC 25923 (MIC 25 uM), E. coli ATCC 25922 (25 uM), M. tuberculosis H37Rv (MIC 11.8 uM), and M. tuberculosis MDR (MIC 5.9 uM) (anti-TB). In culture broth, it only showed a bacte
Evidence 3 Activity

Activity

MIC
Antibacterial
5.9 µM

Target

M. tuberculosis MDR

Source & Reference

NA

Other

C 25923 (MIC 25 uM), E. coli ATCC 25922 (25 uM), M. tuberculosis H37Rv (MIC 11.8 uM), and M. tuberculosis MDR (MIC 5.9 uM) (anti-TB). In culture broth, it only showed a bacteriostatic effect.
Evidence 4 Activity

Activity

MIC
Antifungal
25 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 25 uM), E. coli ATCC 25922 (25 uM), M. tuberculosis H37Rv (MIC 11.8 uM), and M. tuberculosis MDR
Evidence 5 Activity

Activity

MIC
Antifungal
11.8 µM

Target

M. tuberculosis H37Rv

Source & Reference

Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 25 uM), E. coli ATCC 25922 (25 uM), M. tuberculosis H37Rv (MIC 11.8 uM), and M. tuberculosis MDR (MIC 5.9 uM) (anti-TB). In culture broth, it only showed a bacte
Evidence 6 Activity

Activity

MIC
Antifungal
5.9 µM

Target

M. tuberculosis MDR

Source & Reference

Antifungipept

Other

C 25923 (MIC 25 uM), E. coli ATCC 25922 (25 uM), M. tuberculosis H37Rv (MIC 11.8 uM), and M. tuberculosis MDR (MIC 5.9 uM) (anti-TB). In culture broth, it only showed a bacteriostatic effect.
Evidence 7 Activity

Activity

1.8% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
1.8% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity and structure of a consensus human ?-defensin and its comparison to a novel putative hBD10. | Proteins | 2019