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Peptide record

TPDB13683

Antibacterial Anticancer Antiparasitic Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB13683
Antibacterial Anticancer Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia dbAMP 3.0
standard
No
A 35-aa standard-residue multi-activity (Antibacterial, Anticancer, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and dbAMP 3.0, with an available 3D structural model.
Sequence
MDKYIRKEDLGMKMLDVAKILGRRIEKRMEYIAKK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C188H326N54O50S4
NCQHFPSTW
K
4271.23
10.34
11
6
16
+5
2.63
-0.711
92.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2980
0.70
2
Residue Composition
number
2
A
4
R
0
N
3
D
0
C
3
E
0
Q
2
G
0
H
4
I
3
L
7
K
4
M
0
F
0
P
0
S
0
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 3 C: 0 E: 3 Q: 0 G: 2 H: 0 I: 4 L: 3 K: 7 M: 4 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 2 V: 1
Chemical Descriptors
35 reviewed residue count
C188H326N54O50S4 sequence-only estimate (linear, free termini)
4271.23 sequence-only estimate (linear, free termini)
10.34 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
2.63 sequence-only estimate (linear, free termini)
-0.711 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
8-256 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 8-256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation. | PLoS Negl Trop Dis | 2013