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Peptide record

TPDB13681

Antibacterial Anticancer Antifungal Antiparasitic standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB13681
Antibacterial Anticancer Antifungal Antiparasitic
Anti-infective peptides Cancer-related peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept
standard
No
A 35-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWKIFKKIERVGQNVRDGIIKAGPAIQVLGTAKAL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C177H301N53O44
CHMSY
IK
3875.67
11.58
8
2
16
+6
1.30
-0.074
114.29
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
1.42
4
Residue Composition
number
4
A
3
R
1
N
1
D
0
C
1
E
2
Q
4
G
0
H
5
I
2
L
5
K
0
M
1
F
1
P
0
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 2 G: 4 H: 0 I: 5 L: 2 K: 5 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
35 reviewed residue count
C177H301N53O44 sequence-only estimate (linear, free termini)
3875.67 sequence-only estimate (linear, free termini)
11.58 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
1.30 sequence-only estimate (linear, free termini)
-0.074 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli KCTC 1682 (LC 9.3 uM), E. cloacae KCTC 2361 (LC 9.3 uM), P. aeruginosa KCTC 2004 (LC 37.5 uM), S. typhymurium KCTC 1925 (LC 3.7 uM), S. sonnei KCTC 2518 (LC 4.6 uM), B. megaterium KCTC 3007 (LC 4.6 uM), M. luteus KCTC 3063 (LC 6.5 uM), and C. tropicalis KCTC 7221 (LC 3.7 uM). LC = lethal concentration. UPdated 7/2021 5/2023
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli KCTC 1682 (LC 9.3 uM), E. cloacae KCTC 2361 (LC 9.3 uM), P. aeruginosa KCTC 2004 (LC 37.5 uM), S. typhymurium KCTC 1925 (LC 3.7 uM), S. sonnei KCTC 2518 (LC 4.6 uM), B. megaterium KCTC 3007 (LC 4.6 uM), M. luteus KCTC 3063 (LC 6.5 uM), and C. tropicalis KCTC 7221 (LC 3.7 uM). LC = lethal concentration. UPdated 7/2021 5/2023
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

DRAMP

Other

Active against E. coli KCTC 1682 (LC 9.3 uM), E. cloacae KCTC 2361 (LC 9.3 uM), P. aeruginosa KCTC 2004 (LC 37.5 uM), S. typhymurium KCTC 1925 (LC 3.7 uM), S. sonnei KCTC 2518 (LC 4.6 uM), B. megaterium KCTC 3007 (LC 4.6 uM), M. luteus KCTC 3063 (LC 6.5 uM), and C. tropicalis KCTC 7221 (LC 3.7 uM). LC = lethal concentration. UPdated 7/2021 5/2023