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Peptide record

TPDB13680

Antibacterial Antifungal Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB13680
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
PIRTKRRWKLIKKGGKIVKDLLTKNNIIILPGGNE
Physicochemical Analysis
C183H321N55O45
ACQHMFSY
K
4011.90
11.66
10
2
12
+8
9.21
-0.543
119.71
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
5500
137.09
5
Residue Composition
number
0
A
3
R
3
N
1
D
0
C
1
E
0
Q
4
G
0
H
6
I
4
L
7
K
0
M
0
F
2
P
0
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 3 D: 1 C: 0 E: 1 Q: 0 G: 4 H: 0 I: 6 L: 4 K: 7 M: 0 F: 0 P: 2 S: 0 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
35
C183H321N55O45
4011.90
11.66
+8
9.21
-0.543
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.9 µM

Target

Staphylococcus aureus ATCC29213 or MRSA or animal isolates

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli ATCC25922 or (3.1-15.9 uM), S. aureus ATCC29213 or MRSA or animal isolates (MIC 3.9 uM). Activity against many more strains (MIC >15.9 uM).
Evidence 2 Activity

Activity

MIC
Antifungal
3.9 µM

Target

Staphylococcus aureus ATCC29213 or MRSA or animal isolates

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli ATCC25922 or (3.1-15.9 uM), S. aureus ATCC29213 or MRSA or animal isolates (MIC 3.9 uM). Activity against many more strains (MIC >15.9 uM).
Evidence 3 Activity

Activity

<10% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
<10% Hemolysis | 50 | µM | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
Marsupial and Monotreme Cathelicidins Display Antimicrobial Activity, Including Against Methicillin-Resistant Staphylococcus Aureus | Microbiology | 2017
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Madin-Darby bovine kidney cells

Target

Madin-Darby bovine kidney cells

Source & Reference

NA
DBAASP
Marsupial and Monotreme Cathelicidins Display Antimicrobial Activity, Including Against Methicillin-Resistant Staphylococcus Aureus | Microbiology | 2017