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Peptide record

TPDB13679

Antibacterial Anticancer Antifungal Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB13679
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWKIFKKIEKMGRNIRDGIVKAGPAIQVLGSAKAI
Physicochemical Analysis
C177H303N53O43S1
CHTY
IK
3893.74
11.62
9
2
16
+7
7.07
-0.134
106.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
141.25
3
Residue Composition
number
4
A
3
R
1
N
1
D
0
C
1
E
1
Q
4
G
0
H
6
I
1
L
6
K
1
M
1
F
1
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 4 H: 0 I: 6 L: 1 K: 6 M: 1 F: 1 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
35
C177H303N53O43S1
3893.74
11.62
+7
7.07
-0.134
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Killing
Toxicity
200 µM
Cytotoxic
10% Killing | 200 | µM | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Enhanced Silkworm Cecropin B Antimicrobial Activity against Pseudomonas aeruginosa from Single Amino Acid Variation. | ACS Infect Dis | 2019
Evidence 2 Activity

Activity

1% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
1% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Enhanced Silkworm Cecropin B Antimicrobial Activity against Pseudomonas aeruginosa from Single Amino Acid Variation. | ACS Infect Dis | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
0.1 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31045339] 0.1% hemolysis at 20µM, 0.5% hemolysis at 30µM, 0.5% hemolysis at 200µM against human red blood cells | Cytotoxicity: [Ref.31045339] ①The cell viability of Hela cells induced by CecB Q53 is 102.6%, 104.0%, 99.1% and 95.6% at peptide concentrations of 10, 20, 30 and 200 µM. ②The cell viability of CCD cells induced by CecB Q53 is 108.4%, 111.5%, 108.8% and 88.5% at peptide concentrations of 10, 20, 30 and 200 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Infect Dis. 2019 May 10. doi: 10.1021/acsinfecdis.9b00042.