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Peptide record

TPDB13679

Antibacterial Anticancer Antifungal Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB13679
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 35-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWKIFKKIEKMGRNIRDGIVKAGPAIQVLGSAKAI
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C177H303N53O43S1
CHTY
IK
3893.74
11.62
9
2
16
+7
1.37
-0.134
106.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
1.41
3
Residue Composition
number
4
A
3
R
1
N
1
D
0
C
1
E
1
Q
4
G
0
H
6
I
1
L
6
K
1
M
1
F
1
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 4 H: 0 I: 6 L: 1 K: 6 M: 1 F: 1 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
35 reviewed residue count
C177H303N53O43S1 sequence-only estimate (linear, free termini)
3893.74 sequence-only estimate (linear, free termini)
11.62 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
1.37 sequence-only estimate (linear, free termini)
-0.134 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Killing
Toxicity
200 µM
Cytotoxic
10% Killing | 200 | µM | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Enhanced Silkworm Cecropin B Antimicrobial Activity against Pseudomonas aeruginosa from Single Amino Acid Variation. | ACS Infect Dis | 2019
Evidence 2 Activity

Activity

1% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
1% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Enhanced Silkworm Cecropin B Antimicrobial Activity against Pseudomonas aeruginosa from Single Amino Acid Variation. | ACS Infect Dis | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
0.1 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31045339] 0.1% hemolysis at 20µM, 0.5% hemolysis at 30µM, 0.5% hemolysis at 200µM against human red blood cells | Cytotoxicity: [Ref.31045339] ①The cell viability of Hela cells induced by CecB Q53 is 102.6%, 104.0%, 99.1% and 95.6% at peptide concentrations of 10, 20, 30 and 200 µM. ②The cell viability of CCD cells induced by CecB Q53 is 108.4%, 111.5%, 108.8% and 88.5% at peptide concentrations of 10, 20, 30 and 200 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Infect Dis. 2019 May 10. doi: 10.1021/acsinfecdis.9b00042.