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Peptide record

TPDB13677

R9-magainin Antibacterial Cell-penetrating Peptides Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB13677
R9-magainin
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and CPPsite3.0, with an available 3D structural model.
Sequence
RRRRRRRRRGGGGIGKWLHSAKKFGKAFVGEIMNS
Physicochemical Analysis
C176H298N70O41S1
DCQPTY
R
4082.81
12.95
14
1
10
+12
9.19
-1.243
47.43
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
134.71
3
Residue Composition
number
2
A
9
R
1
N
0
D
0
C
1
E
0
Q
7
G
1
H
2
I
1
L
4
K
1
M
2
F
0
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 9 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 7 H: 1 I: 2 L: 1 K: 4 M: 1 F: 2 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
35
C176H298N70O41S1
4082.81
12.95
+12
9.19
-1.243
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

E. coli (KCTC 1682)
E. coli (KCTC 1682)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
FITC-labeled & Magainin
Cytoplasm
In vivo
CCCCTTSCCCCCCHHHHCCGGGGGSGGGCGGGCC
Evidence 2 Activity

Activity

2.3% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
2.3% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Conjugation of Cell-Penetrating Peptides to Antimicrobial Peptides Enhances Antibacterial Activity. | ACS Omega | 2019
Additional Detail Fields 1 fields
CCCCTTSCCCCCCHHHHCCGGGGGSGGGCGGGCC