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Peptide record

TPDB13664

Antibacterial Antifungal Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB13664
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
SLLWRWNSMKPVGASCRDHLECGTKYCRRSICTF
Physicochemical Analysis
C173H271N53O47S5
Q
RCS
4005.68
9.21
7
2
11
+4
2.07
-0.382
57.35
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
12740
318.05
12
Residue Composition
number
1
A
4
R
1
N
1
D
4
C
1
E
0
Q
2
G
1
H
1
I
3
L
2
K
1
M
1
F
1
P
4
S
2
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 1 D: 1 C: 4 E: 1 Q: 0 G: 2 H: 1 I: 1 L: 3 K: 2 M: 1 F: 1 P: 1 S: 4 T: 2 W: 2 Y: 1 V: 1
Chemical Descriptors
34
C173H271N53O47S5
4005.68
9.21
+4
2.07
-0.382
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25-12.5 µM

Target

B. subtilis

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ bacteria B-cereus (MIC>50 uM), B. subtilis (MIC 6.25-12.5 uM), S-aureus (>50 uM), C. glutamicum (MIC 1.56-3.12 uM), S. epidermidis (MIC 12.5-25 uM), Gr
Evidence 2 Activity

Activity

MIC
Antibacterial
1.56-3.12 µM

Target

C. glutamicum

Source & Reference

dbAMP

Other

t Gram+ bacteria B-cereus (MIC>50 uM), B. subtilis (MIC 6.25-12.5 uM), S-aureus (>50 uM), C. glutamicum (MIC 1.56-3.12 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluores
Evidence 3 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

uM), B. subtilis (MIC 6.25-12.5 uM), S-aureus (>50 uM), C. glutamicum (MIC 1.56-3.12 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 12.5-25 uM), P. stutzer
Evidence 4 Activity

Activity

MIC
Antibacterial
25-50 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

50 uM), C. glutamicum (MIC 1.56-3.12 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 12.5-25 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50), E
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5-25 µM

Target

Pseudomonas fluorescens

Source & Reference

dbAMP

Other

6-3.12 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 12.5-25 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50), E. coli (25-50 uM), S. flexneri (1
Evidence 6 Activity

Activity

MIC
Antibacterial
3.1-6.25 µM

Target

Pseudomonas stutzeri

Source & Reference

dbAMP

Other

2.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 12.5-25 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50), E. coli (25-50 uM), S. flexneri (12.5-25 uM), V-parahaemolyticus,
Evidence 7 Activity

Activity

MIC
Antibacterial
3.1-6.25 µM

Target

C. neoformans

Source & Reference

dbAMP

Other

5 uM), V-parahaemolyticus, V-alginolyticus (MIC>50 uM), fungi C-albicans (MIC>50 uM), amd C. neoformans (MIC 3.1-6.25 uM). Dose-depeendent LPS stimulation led to its highest expression at 6 h. Updated Jan2020 7
Evidence 8 Activity

Activity

MIC
Antifungal
6.25-12.5 µM

Target

B. subtilis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ bacteria B-cereus (MIC>50 uM), B. subtilis (MIC 6.25-12.5 uM), S-aureus (>50 uM), C. glutamicum (MIC 1.56-3.12 uM), S. epidermidis (MIC 12.5-25 uM), Gr
Evidence 9 Activity

Activity

MIC
Antifungal
1.56-3.12 µM

Target

C. glutamicum

Source & Reference

dbAMP CAFPdb Antifungipept

Other

t Gram+ bacteria B-cereus (MIC>50 uM), B. subtilis (MIC 6.25-12.5 uM), S-aureus (>50 uM), C. glutamicum (MIC 1.56-3.12 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluores
Evidence 10 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM), B. subtilis (MIC 6.25-12.5 uM), S-aureus (>50 uM), C. glutamicum (MIC 1.56-3.12 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 12.5-25 uM), P. stutzer
Evidence 11 Activity

Activity

MIC
Antifungal
25-50 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

50 uM), C. glutamicum (MIC 1.56-3.12 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 12.5-25 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50), E
Evidence 12 Activity

Activity

MIC
Antifungal
12.5-25 µM

Target

Pseudomonas fluorescens

Source & Reference

dbAMP CAFPdb Antifungipept

Other

6-3.12 uM), S. epidermidis (MIC 12.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 12.5-25 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50), E. coli (25-50 uM), S. flexneri (1
Evidence 13 Activity

Activity

MIC
Antifungal
3.1-6.25 µM

Target

Pseudomonas stutzeri

Source & Reference

dbAMP CAFPdb Antifungipept

Other

2.5-25 uM), Gram- bacteria P. aeruginosa (MIC 25-50 uM), P. fluorescens (MIC 12.5-25 uM), P. stutzeri (MIC 3.1-6.25 uM), A-hydrophila (MIC>50), E. coli (25-50 uM), S. flexneri (12.5-25 uM), V-parahaemolyticus,
Evidence 14 Activity

Activity

MIC
Antifungal
3.1-6.25 µM

Target

C. neoformans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

5 uM), V-parahaemolyticus, V-alginolyticus (MIC>50 uM), fungi C-albicans (MIC>50 uM), amd C. neoformans (MIC 3.1-6.25 uM). Dose-depeendent LPS stimulation led to its highest expression at 6 h. Updated Jan2020 7
Evidence 15 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse hepatocytes AML12

Target

Mouse hepatocytes AML12

Source & Reference

NA
DBAASP
Antimicrobial activity and mechanisms of multiple antimicrobial peptides isolated from rockfish Sebastiscus marmoratus. | Fish Shellfish Immunol | 2019