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Peptide record

TPDB13660

Antibacterial Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB13660
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 34-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
NIKISGKWKAQKRFLKGGGRLLRPLLQLLKQKLR
Physicochemical Analysis
C184H322N58O40
DCEHMTYV
L
3986.95
12.89
11
0
13
+11
4.70
-0.594
117.65
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
5500
137.95
5
Residue Composition
number
1
A
4
R
1
N
0
D
0
C
0
E
3
Q
4
G
0
H
2
I
8
L
7
K
0
M
1
F
1
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 3 G: 4 H: 0 I: 2 L: 8 K: 7 M: 0 F: 1 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
34
C184H322N58O40
3986.95
12.89
+11
4.70
-0.594
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
5% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Enhancement of the antimicrobial activity and selectivity of GNU7 against Gram-negative bacteria by fusion with LPS-targeting peptide. | Peptides | 2016
Evidence 2 Activity

Activity

15% Killing
Toxicity
8 µM
Cytotoxic
15% Killing | 8 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Enhancement of the antimicrobial activity and selectivity of GNU7 against Gram-negative bacteria by fusion with LPS-targeting peptide. | Peptides | 2016