TPDB13656

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.69-9.38 ug/mL

Target

Target Organism Escherichia coli ATCC25922 and clinical strains

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli ATCC25922 and clinical strains (MIC 4.69-9.38 ug/mL), S. dysenteriae (MIC 1.17 ug/ml), K. Pneumoniae (MIC 9.38-18.75 ug/ml), S. maltophilia (M

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.17 µg/mL

Target

Target Organism S. dysenteriae

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli ATCC25922 and clinical strains (MIC 4.69-9.38 ug/mL), S. dysenteriae (MIC 1.17 ug/ml), K. Pneumoniae (MIC 9.38-18.75 ug/ml), S. maltophilia (MIC 18.7 ug/ml), K. oxytoca (MIC 1

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism K. Pneumoniae

Source & Reference

Database Source dbAMP

Other

Evidence Text

li ATCC25922 and clinical strains (MIC 4.69-9.38 ug/mL), S. dysenteriae (MIC 1.17 ug/ml), K. Pneumoniae (MIC 9.38-18.75 ug/ml), S. maltophilia (MIC 18.7 ug/ml), K. oxytoca (MIC 18.75 ug/ml), P. vulgaris (MIC 18.75 ug

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.7 µg/mL

Target

Target Organism Stenotrophomonas maltophilia

Source & Reference

Database Source dbAMP

Other

Evidence Text

4.69-9.38 ug/mL), S. dysenteriae (MIC 1.17 ug/ml), K. Pneumoniae (MIC 9.38-18.75 ug/ml), S. maltophilia (MIC 18.7 ug/ml), K. oxytoca (MIC 18.75 ug/ml), P. vulgaris (MIC 18.75 ug/ml), P. mirabilis (MIC 18.75 ug/

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism Klebsiella oxytoca

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 1.17 ug/ml), K. Pneumoniae (MIC 9.38-18.75 ug/ml), S. maltophilia (MIC 18.7 ug/ml), K. oxytoca (MIC 18.75 ug/ml), P. vulgaris (MIC 18.75 ug/ml), P. mirabilis (MIC 18.75 ug/ml), A. baumannii (MIC 18.75 u

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism P. vulgaris

Source & Reference

Database Source dbAMP

Other

Evidence Text

ae (MIC 9.38-18.75 ug/ml), S. maltophilia (MIC 18.7 ug/ml), K. oxytoca (MIC 18.75 ug/ml), P. vulgaris (MIC 18.75 ug/ml), P. mirabilis (MIC 18.75 ug/ml), A. baumannii (MIC 18.75 ug/ml), S. maltophilia (MIC 18.7

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism P. mirabilis

Source & Reference

Database Source dbAMP

Other

Evidence Text

altophilia (MIC 18.7 ug/ml), K. oxytoca (MIC 18.75 ug/ml), P. vulgaris (MIC 18.75 ug/ml), P. mirabilis (MIC 18.75 ug/ml), A. baumannii (MIC 18.75 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa (MIC 2.3

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism A. baumannii

Source & Reference

Database Source dbAMP

Other

Evidence Text

oxytoca (MIC 18.75 ug/ml), P. vulgaris (MIC 18.75 ug/ml), P. mirabilis (MIC 18.75 ug/ml), A. baumannii (MIC 18.75 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa (MIC 2.3-9.3 (MIC 18.75 ug/ml), S. aureu

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.75 µg/mL

Target

Target Organism Stenotrophomonas maltophilia

Source & Reference

Database Source dbAMP

Other

Evidence Text

lgaris (MIC 18.75 ug/ml), P. mirabilis (MIC 18.75 ug/ml), A. baumannii (MIC 18.75 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa (MIC 2.3-9.3 (MIC 18.75 ug/ml), S. aureus clinical strains (MIC 4.69-9.38

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.34 µg/mL

Target

Target Organism E. faecium

Source & Reference

Database Source dbAMP

Other

Evidence Text

5 ug/ml), B. cereus (MIC 9.38 (MIC 18.75 ug/ml), B. subtilis (MIC 4.69 (MIC 18.75 ug/ml), E. faecium (MIC 2.34 ug/ml), N. asteroides (MIC 2.34 ug/ml), E. faecalis (MIC 75 ug/ml), S. epidermidis (MIC 9.38 ug/

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.34 µg/mL

Target

Target Organism N. asteroides

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 18.75 ug/ml), B. subtilis (MIC 4.69 (MIC 18.75 ug/ml), E. faecium (MIC 2.34 ug/ml), N. asteroides (MIC 2.34 ug/ml), E. faecalis (MIC 75 ug/ml), S. epidermidis (MIC 9.38 ug/mL), fungi C. albicans (MIC 9.38

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 75 µg/mL

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 4.69 (MIC 18.75 ug/ml), E. faecium (MIC 2.34 ug/ml), N. asteroides (MIC 2.34 ug/ml), E. faecalis (MIC 75 ug/ml), S. epidermidis (MIC 9.38 ug/mL), fungi C. albicans (MIC 9.38 ug/ml), C. neoformans (18.7

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 ug/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP

Other

Evidence Text

E. faecium (MIC 2.34 ug/ml), N. asteroides (MIC 2.34 ug/ml), E. faecalis (MIC 75 ug/ml), S. epidermidis (MIC 9.38 ug/mL), fungi C. albicans (MIC 9.38 ug/ml), C. neoformans (18.75 ug/ml), aquatic pathogens V. br

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

ides (MIC 2.34 ug/ml), E. faecalis (MIC 75 ug/ml), S. epidermidis (MIC 9.38 ug/mL), fungi C. albicans (MIC 9.38 ug/ml), C. neoformans (18.75 ug/ml), aquatic pathogens V. brasiliensis (MIC 18.7 ug/ml), V. chol

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.7 µg/mL

Target

Target Organism V. brasiliensis

Source & Reference

Database Source dbAMP

Other

Evidence Text

g/mL), fungi C. albicans (MIC 9.38 ug/ml), C. neoformans (18.75 ug/ml), aquatic pathogens V. brasiliensis (MIC 18.7 ug/ml), V. cholerae (18.7 ug/ml), A. veronii (MIC 9.3 ug/ml), and E. tarda (MIC 18.7 ug/ml). In

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.3 µg/mL

Target

Target Organism A. veronii

Source & Reference

Database Source dbAMP

Other

Evidence Text

.75 ug/ml), aquatic pathogens V. brasiliensis (MIC 18.7 ug/ml), V. cholerae (18.7 ug/ml), A. veronii (MIC 9.3 ug/ml), and E. tarda (MIC 18.7 ug/ml). In a separate study, this peptide also showed good activi

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 18.7 µg/mL

Target

Target Organism E. tarda

Source & Reference

Database Source dbAMP

Other

Evidence Text

brasiliensis (MIC 18.7 ug/ml), V. cholerae (18.7 ug/ml), A. veronii (MIC 9.3 ug/ml), and E. tarda (MIC 18.7 ug/ml). In a separate study, this peptide also showed good activity against aquatic bacteria Gra

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.58 µM

Target

Target Organism V. alginolyticus

Source & Reference

Database Source dbAMP

Other

Evidence Text

n a separate study, this peptide also showed good activity against aquatic bacteria Gram- V. alginolyticus (MIC 4.58 uM), V. anguillarum, V. brasiliensis (MIC 1.15 uM), V. cholerae (MIC 0.57 uM), V. fluvialis (

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.15 µM

Target

Target Organism V. brasiliensis

Source & Reference

Database Source dbAMP

Other

Evidence Text

d activity against aquatic bacteria Gram- V. alginolyticus (MIC 4.58 uM), V. anguillarum, V. brasiliensis (MIC 1.15 uM), V. cholerae (MIC 0.57 uM), V. fluvialis (MIC 1.15 uM), V. harveyi (MIC 1.15 uM), V. para

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.57 µM

Target

Target Organism V. cholerae

Source & Reference

Database Source dbAMP

Other

Evidence Text

eria Gram- V. alginolyticus (MIC 4.58 uM), V. anguillarum, V. brasiliensis (MIC 1.15 uM), V. cholerae (MIC 0.57 uM), V. fluvialis (MIC 1.15 uM), V. harveyi (MIC 1.15 uM), V. parahaemolyticus (MIC 0.57 uM),

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.15 µM

Target

Target Organism V. fluvialis

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 4.58 uM), V. anguillarum, V. brasiliensis (MIC 1.15 uM), V. cholerae (MIC 0.57 uM), V. fluvialis (MIC 1.15 uM), V. harveyi (MIC 1.15 uM), V. parahaemolyticus (MIC 0.57 uM), V. splendidus (MIC 1.15 uM)

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.15 µM

Target

Target Organism V. harveyi

Source & Reference

Database Source dbAMP

Other

Evidence Text

um, V. brasiliensis (MIC 1.15 uM), V. cholerae (MIC 0.57 uM), V. fluvialis (MIC 1.15 uM), V. harveyi (MIC 1.15 uM), V. parahaemolyticus (MIC 0.57 uM), V. splendidus (MIC 1.15 uM), V. vulnificus. (MIC 4.58

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.57 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source dbAMP

Other

Evidence Text

.15 uM), V. cholerae (MIC 0.57 uM), V. fluvialis (MIC 1.15 uM), V. harveyi (MIC 1.15 uM), V. parahaemolyticus (MIC 0.57 uM), V. splendidus (MIC 1.15 uM), V. vulnificus. (MIC 4.58 uM), A. hydrophila (MIC 1.15 uM),

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.15 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source dbAMP

Other

Evidence Text

V. fluvialis (MIC 1.15 uM), V. harveyi (MIC 1.15 uM), V. parahaemolyticus (MIC 0.57 uM), V. splendidus (MIC 1.15 uM), V. vulnificus. (MIC 4.58 uM), A. hydrophila (MIC 1.15 uM), A. sobria (MIC 2.29 uM), A.ve

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.15 µM

Target

Target Organism A. hydrophila

Source & Reference

Database Source dbAMP

Other

Evidence Text

arahaemolyticus (MIC 0.57 uM), V. splendidus (MIC 1.15 uM), V. vulnificus. (MIC 4.58 uM), A. hydrophila (MIC 1.15 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 2.29 uM), and N. asteroides (MIC 1.15 uM) ( Ouya

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.29 µM

Target

Target Organism A. sobria

Source & Reference

Database Source dbAMP

Other

Evidence Text

, V. splendidus (MIC 1.15 uM), V. vulnificus. (MIC 4.58 uM), A. hydrophila (MIC 1.15 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 2.29 uM), and N. asteroides (MIC 1.15 uM) ( Ouyang et al., 2022 ).

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.29 µM

Target

Target Organism A.veronii

Source & Reference

Database Source dbAMP

Other

Evidence Text

uM), V. vulnificus. (MIC 4.58 uM), A. hydrophila (MIC 1.15 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 2.29 uM), and N. asteroides (MIC 1.15 uM) ( Ouyang et al., 2022 ).

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.15 µM

Target

Target Organism N. asteroides

Source & Reference

Database Source dbAMP

Other

Evidence Text

8 uM), A. hydrophila (MIC 1.15 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 2.29 uM), and N. asteroides (MIC 1.15 uM) ( Ouyang et al., 2022 ).

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.69-9.38 ug/mL

Target

Target Organism Escherichia coli ATCC25922 and clinical strains

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli ATCC25922 and clinical strains (MIC 4.69-9.38 ug/mL), S. dysenteriae (MIC 1.17 ug/ml), K. Pneumoniae (MIC 9.38-18.75 ug/ml), S. maltophilia (M

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.17 µg/mL

Target

Target Organism S. dysenteriae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC25922 and clinical strains (MIC 4.69-9.38 ug/mL), S. dysenteriae (MIC 1.17 ug/ml), K. Pneumoniae (MIC 9.38-18.75 ug/ml), S. maltophilia (MIC 18.7 ug/ml), K. oxytoca (MIC 1

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38-18.75 µg/mL

Target

Target Organism K. Pneumoniae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

li ATCC25922 and clinical strains (MIC 4.69-9.38 ug/mL), S. dysenteriae (MIC 1.17 ug/ml), K. Pneumoniae (MIC 9.38-18.75 ug/ml), S. maltophilia (MIC 18.7 ug/ml), K. oxytoca (MIC 18.75 ug/ml), P. vulgaris (MIC 18.75 ug

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.7 µg/mL

Target

Target Organism Stenotrophomonas maltophilia

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

4.69-9.38 ug/mL), S. dysenteriae (MIC 1.17 ug/ml), K. Pneumoniae (MIC 9.38-18.75 ug/ml), S. maltophilia (MIC 18.7 ug/ml), K. oxytoca (MIC 18.75 ug/ml), P. vulgaris (MIC 18.75 ug/ml), P. mirabilis (MIC 18.75 ug/

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism Klebsiella oxytoca

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 1.17 ug/ml), K. Pneumoniae (MIC 9.38-18.75 ug/ml), S. maltophilia (MIC 18.7 ug/ml), K. oxytoca (MIC 18.75 ug/ml), P. vulgaris (MIC 18.75 ug/ml), P. mirabilis (MIC 18.75 ug/ml), A. baumannii (MIC 18.75 u

Evidence 34 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism P. vulgaris

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ae (MIC 9.38-18.75 ug/ml), S. maltophilia (MIC 18.7 ug/ml), K. oxytoca (MIC 18.75 ug/ml), P. vulgaris (MIC 18.75 ug/ml), P. mirabilis (MIC 18.75 ug/ml), A. baumannii (MIC 18.75 ug/ml), S. maltophilia (MIC 18.7

Evidence 35 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism P. mirabilis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

altophilia (MIC 18.7 ug/ml), K. oxytoca (MIC 18.75 ug/ml), P. vulgaris (MIC 18.75 ug/ml), P. mirabilis (MIC 18.75 ug/ml), A. baumannii (MIC 18.75 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa (MIC 2.3

Evidence 36 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism A. baumannii

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

oxytoca (MIC 18.75 ug/ml), P. vulgaris (MIC 18.75 ug/ml), P. mirabilis (MIC 18.75 ug/ml), A. baumannii (MIC 18.75 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa (MIC 2.3-9.3 (MIC 18.75 ug/ml), S. aureu

Evidence 37 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.75 µg/mL

Target

Target Organism Stenotrophomonas maltophilia

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

lgaris (MIC 18.75 ug/ml), P. mirabilis (MIC 18.75 ug/ml), A. baumannii (MIC 18.75 ug/ml), S. maltophilia (MIC 18.75 ug/ml), P. aeruginosa (MIC 2.3-9.3 (MIC 18.75 ug/ml), S. aureus clinical strains (MIC 4.69-9.38

Evidence 38 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.34 µg/mL

Target

Target Organism E. faecium

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

5 ug/ml), B. cereus (MIC 9.38 (MIC 18.75 ug/ml), B. subtilis (MIC 4.69 (MIC 18.75 ug/ml), E. faecium (MIC 2.34 ug/ml), N. asteroides (MIC 2.34 ug/ml), E. faecalis (MIC 75 ug/ml), S. epidermidis (MIC 9.38 ug/

Evidence 39 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.34 µg/mL

Target

Target Organism N. asteroides

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 18.75 ug/ml), B. subtilis (MIC 4.69 (MIC 18.75 ug/ml), E. faecium (MIC 2.34 ug/ml), N. asteroides (MIC 2.34 ug/ml), E. faecalis (MIC 75 ug/ml), S. epidermidis (MIC 9.38 ug/mL), fungi C. albicans (MIC 9.38

Evidence 40 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 75 µg/mL

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 4.69 (MIC 18.75 ug/ml), E. faecium (MIC 2.34 ug/ml), N. asteroides (MIC 2.34 ug/ml), E. faecalis (MIC 75 ug/ml), S. epidermidis (MIC 9.38 ug/mL), fungi C. albicans (MIC 9.38 ug/ml), C. neoformans (18.7

Evidence 41 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 ug/mL

Target

Target Organism Staphylococcus epidermidis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

E. faecium (MIC 2.34 ug/ml), N. asteroides (MIC 2.34 ug/ml), E. faecalis (MIC 75 ug/ml), S. epidermidis (MIC 9.38 ug/mL), fungi C. albicans (MIC 9.38 ug/ml), C. neoformans (18.75 ug/ml), aquatic pathogens V. br

Evidence 42 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ides (MIC 2.34 ug/ml), E. faecalis (MIC 75 ug/ml), S. epidermidis (MIC 9.38 ug/mL), fungi C. albicans (MIC 9.38 ug/ml), C. neoformans (18.75 ug/ml), aquatic pathogens V. brasiliensis (MIC 18.7 ug/ml), V. chol

Evidence 43 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.7 µg/mL

Target

Target Organism V. brasiliensis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

g/mL), fungi C. albicans (MIC 9.38 ug/ml), C. neoformans (18.75 ug/ml), aquatic pathogens V. brasiliensis (MIC 18.7 ug/ml), V. cholerae (18.7 ug/ml), A. veronii (MIC 9.3 ug/ml), and E. tarda (MIC 18.7 ug/ml). In

Evidence 44 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.3 µg/mL

Target

Target Organism A. veronii

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

.75 ug/ml), aquatic pathogens V. brasiliensis (MIC 18.7 ug/ml), V. cholerae (18.7 ug/ml), A. veronii (MIC 9.3 ug/ml), and E. tarda (MIC 18.7 ug/ml). In a separate study, this peptide also showed good activi

Evidence 45 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 18.7 µg/mL

Target

Target Organism E. tarda

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

brasiliensis (MIC 18.7 ug/ml), V. cholerae (18.7 ug/ml), A. veronii (MIC 9.3 ug/ml), and E. tarda (MIC 18.7 ug/ml). In a separate study, this peptide also showed good activity against aquatic bacteria Gra

Evidence 46 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.58 µM

Target

Target Organism V. alginolyticus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

n a separate study, this peptide also showed good activity against aquatic bacteria Gram- V. alginolyticus (MIC 4.58 uM), V. anguillarum, V. brasiliensis (MIC 1.15 uM), V. cholerae (MIC 0.57 uM), V. fluvialis (

Evidence 47 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.15 µM

Target

Target Organism V. brasiliensis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

d activity against aquatic bacteria Gram- V. alginolyticus (MIC 4.58 uM), V. anguillarum, V. brasiliensis (MIC 1.15 uM), V. cholerae (MIC 0.57 uM), V. fluvialis (MIC 1.15 uM), V. harveyi (MIC 1.15 uM), V. para

Evidence 48 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.57 µM

Target

Target Organism V. cholerae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

eria Gram- V. alginolyticus (MIC 4.58 uM), V. anguillarum, V. brasiliensis (MIC 1.15 uM), V. cholerae (MIC 0.57 uM), V. fluvialis (MIC 1.15 uM), V. harveyi (MIC 1.15 uM), V. parahaemolyticus (MIC 0.57 uM),

Evidence 49 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.15 µM

Target

Target Organism V. fluvialis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 4.58 uM), V. anguillarum, V. brasiliensis (MIC 1.15 uM), V. cholerae (MIC 0.57 uM), V. fluvialis (MIC 1.15 uM), V. harveyi (MIC 1.15 uM), V. parahaemolyticus (MIC 0.57 uM), V. splendidus (MIC 1.15 uM)

Evidence 50 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.15 µM

Target

Target Organism V. harveyi

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

um, V. brasiliensis (MIC 1.15 uM), V. cholerae (MIC 0.57 uM), V. fluvialis (MIC 1.15 uM), V. harveyi (MIC 1.15 uM), V. parahaemolyticus (MIC 0.57 uM), V. splendidus (MIC 1.15 uM), V. vulnificus. (MIC 4.58

Evidence 51 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.57 µM

Target

Target Organism V. parahaemolyticus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

.15 uM), V. cholerae (MIC 0.57 uM), V. fluvialis (MIC 1.15 uM), V. harveyi (MIC 1.15 uM), V. parahaemolyticus (MIC 0.57 uM), V. splendidus (MIC 1.15 uM), V. vulnificus. (MIC 4.58 uM), A. hydrophila (MIC 1.15 uM),

Evidence 52 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.15 µM

Target

Target Organism V. splendidus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

V. fluvialis (MIC 1.15 uM), V. harveyi (MIC 1.15 uM), V. parahaemolyticus (MIC 0.57 uM), V. splendidus (MIC 1.15 uM), V. vulnificus. (MIC 4.58 uM), A. hydrophila (MIC 1.15 uM), A. sobria (MIC 2.29 uM), A.ve

Evidence 53 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.15 µM

Target

Target Organism A. hydrophila

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

arahaemolyticus (MIC 0.57 uM), V. splendidus (MIC 1.15 uM), V. vulnificus. (MIC 4.58 uM), A. hydrophila (MIC 1.15 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 2.29 uM), and N. asteroides (MIC 1.15 uM) ( Ouya

Evidence 54 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.29 µM

Target

Target Organism A. sobria

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

, V. splendidus (MIC 1.15 uM), V. vulnificus. (MIC 4.58 uM), A. hydrophila (MIC 1.15 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 2.29 uM), and N. asteroides (MIC 1.15 uM) ( Ouyang et al., 2022 ).

Evidence 55 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.29 µM

Target

Target Organism A.veronii

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

uM), V. vulnificus. (MIC 4.58 uM), A. hydrophila (MIC 1.15 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 2.29 uM), and N. asteroides (MIC 1.15 uM) ( Ouyang et al., 2022 ).

Evidence 56 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.15 µM

Target

Target Organism N. asteroides

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

8 uM), A. hydrophila (MIC 1.15 uM), A. sobria (MIC 2.29 uM), A.veronii (MIC 2.29 uM), and N. asteroides (MIC 1.15 uM) ( Ouyang et al., 2022 ).

Evidence 57 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Toxicity

Activity Measurement 238.2 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

IC50 | 238.2 | µg/mL | target cell: Human umbilical vein endothelial cells HUVEC

Target

Target Cell Human umbilical vein endothelial cells HUVEC

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Diversity, immunoregulatory action and structure-activity relationship of green sea turtle cathelicidins. | Dev Comp Immunol

Evidence 58 Activity

Activity

Activity Endpoint 2.05% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

2.05% Hemolysis | 10 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Diversity, immunoregulatory action and structure-activity relationship of green sea turtle cathelicidins. | Dev Comp Immunol

Evidence 59 Activity

Activity

Activity Endpoint 7.91% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

7.91% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Diversity, immunoregulatory action and structure-activity relationship of green sea turtle cathelicidins. | Dev Comp Immunol

Evidence 60 Activity

Activity

Activity Endpoint 10.53% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

10.53% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Diversity, immunoregulatory action and structure-activity relationship of green sea turtle cathelicidins. | Dev Comp Immunol

Evidence 61 Activity

Activity

Activity Endpoint 12.2% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 150 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

12.2% Hemolysis | 150 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Diversity, immunoregulatory action and structure-activity relationship of green sea turtle cathelicidins. | Dev Comp Immunol

Evidence 62 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Dev Comp Immunol. 2019 Sep 98:189-204.