Back to search

Peptide record

TPDB13654

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13654
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb AI4AVP dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
VVCACRRALCLPLERRAGFCRIRGRIHPLCCRR
Physicochemical Analysis
C161H282N62O36S6
NDQKMSTWY
R
3854.76
11.51
10
1
12
+8
5.39
0.139
97.58
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
375
9.73
6
Residue Composition
number
3
A
9
R
0
N
0
D
6
C
1
E
0
Q
2
G
1
H
2
I
4
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 9 N: 0 D: 0 C: 6 E: 1 Q: 0 G: 2 H: 1 I: 2 L: 4 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
33
C161H282N62O36S6
3854.76
11.51
+8
5.39
0.139
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
log deduction after 20 min incubation with 50 ug/ml peptide. Active against S. aureus strains 566, 502A, J.F. (reduction 2.4->4.1 logs), S. epidermidis UCLA-622 (reduction >4.1 logs), S. pneumoniae Type III (reduction >3.5 log), S. agalactiae Type I-A or III (reduction 2.0-2.9 logs), L. monocytogenes 450 (reduction 2.1 logs), P. aeruginosa PAO579 (reduction 3.2 logs), E. coli ATCC 29648 (reduction 0.8 logs), K. pneumoniae ATCC 13883 (reduction 1.1 logs), S. marcescens (reduction 1.0 log), H. influenzae Type 3A (reduction 2.1 log), B. bronchiseptica UCLA-342 (reduction 0.1 log).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
log deduction after 20 min incubation with 50 ug/ml peptide. Active against S. aureus strains 566, 502A, J.F. (reduction 2.4->4.1 logs), S. epidermidis UCLA-622 (reduction >4.1 logs), S. pneumoniae Type III (reduction >3.5 log), S. agalactiae Type I-A or III (reduction 2.0-2.9 logs), L. monocytogenes 450 (reduction 2.1 logs), P. aeruginosa PAO579 (reduction 3.2 logs), E. coli ATCC 29648 (reduction 0.8 logs), K. pneumoniae ATCC 13883 (reduction 1.1 logs), S. marcescens (reduction 1.0 log), H. influenzae Type 3A (reduction 2.1 log), B. bronchiseptica UCLA-342 (reduction 0.1 log).
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
log deduction after 20 min incubation with 50 ug/ml peptide. Active against S. aureus strains 566, 502A, J.F. (reduction 2.4->4.1 logs), S. epidermidis UCLA-622 (reduction >4.1 logs), S. pneumoniae Type III (reduction >3.5 log), S. agalactiae Type I-A or III (reduction 2.0-2.9 logs), L. monocytogenes 450 (reduction 2.1 logs), P. aeruginosa PAO579 (reduction 3.2 logs), E. coli ATCC 29648 (reduction 0.8 logs), K. pneumoniae ATCC 13883 (reduction 1.1 logs), S. marcescens (reduction 1.0 log), H. influenzae Type 3A (reduction 2.1 log), B. bronchiseptica UCLA-342 (reduction 0.1 log).
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
log deduction after 20 min incubation with 50 ug/ml peptide. Active against S. aureus strains 566, 502A, J.F. (reduction 2.4->4.1 logs), S. epidermidis UCLA-622 (reduction >4.1 logs), S. pneumoniae Type III (reduction >3.5 log), S. agalactiae Type I-A or III (reduction 2.0-2.9 logs), L. monocytogenes 450 (reduction 2.1 logs), P. aeruginosa PAO579 (reduction 3.2 logs), E. coli ATCC 29648 (reduction 0.8 logs), K. pneumoniae ATCC 13883 (reduction 1.1 logs), S. marcescens (reduction 1.0 log), H. influenzae Type 3A (reduction 2.1 log), B. bronchiseptica UCLA-342 (reduction 0.1 log).
Evidence 5 Activity

Activity

2% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides. | Eur J Clin Microbiol Infect Dis | 2000