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Peptide record

TPDB13646

Antibacterial Antifungal Antiviral Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB13646
Antibacterial Antifungal Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP DRAVP 2.0 ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GFSSLFKAGAKYLLKQVGKAGAQQLACKAANNC
Physicochemical Analysis
C150H245N43O42S2
RDEHIMPTW
A
3386.98
10.21
5
0
15
+5
0.79
0.033
77.27
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1615
47.68
10
Residue Composition
number
7
A
0
R
2
N
0
D
2
C
0
E
3
Q
4
G
0
H
0
I
4
L
5
K
0
M
2
F
0
P
2
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 7 R: 0 N: 2 D: 0 C: 2 E: 0 Q: 3 G: 4 H: 0 I: 0 L: 4 K: 5 M: 0 F: 2 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
33
C150H245N43O42S2
3386.98
10.21
+5
0.79
0.033
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Weakly active against S. aureus (MIC 64 uM) and E. faecalis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (
Evidence 2 Activity

Activity

MIC
Antibacterial
64 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP

Other

Weakly active against S. aureus (MIC 64 uM) and E. faecalis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (M
Evidence 3 Activity

Activity

MIC
Antibacterial
>512 µM

Target

E.coli

Source & Reference

dbAMP

Other

ctive against S. aureus (MIC 64 uM) and E. faecalis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (MIC >512 uM) and C.albicans (MIC >256 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
>512 µM

Target

P.aeruginosa

Source & Reference

dbAMP

Other

us (MIC 64 uM) and E. faecalis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (MIC >512 uM) and C.albicans (MIC >256 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
>512 µM

Target

K.pneumoniae

Source & Reference

dbAMP

Other

lis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (MIC >512 uM) and C.albicans (MIC >256 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
>256 µM

Target

C.albicans

Source & Reference

dbAMP

Other

-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (MIC >512 uM) and C.albicans (MIC >256 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
64 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Weakly active against S. aureus (MIC 64 uM) and E. faecalis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (
Evidence 8 Activity

Activity

MIC
Antifungal
64 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Weakly active against S. aureus (MIC 64 uM) and E. faecalis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (M
Evidence 9 Activity

Activity

MIC
Antifungal
>512 µM

Target

E.coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ctive against S. aureus (MIC 64 uM) and E. faecalis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (MIC >512 uM) and C.albicans (MIC >256 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
>512 µM

Target

P.aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

us (MIC 64 uM) and E. faecalis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (MIC >512 uM) and C.albicans (MIC >256 uM).
Evidence 11 Activity

Activity

MIC
Antifungal
>512 µM

Target

K.pneumoniae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

lis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (MIC >512 uM) and C.albicans (MIC >256 uM).
Evidence 12 Activity

Activity

MIC
Antifungal
>256 µM

Target

C.albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (MIC >512 uM) and C.albicans (MIC >256 uM).
Evidence 13 Activity

Activity

MIC
Antiviral
64 µM

Target

Staphylococcus aureus

Source & Reference

DRAVP 2.0

Other

Weakly active against S. aureus (MIC 64 uM) and E. faecalis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (
Evidence 14 Activity

Activity

MIC
Antiviral
64 µM

Target

Enterococcus faecalis

Source & Reference

DRAVP 2.0

Other

Weakly active against S. aureus (MIC 64 uM) and E. faecalis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (M
Evidence 15 Activity

Activity

MIC
Antiviral
>512 µM

Target

E.coli

Source & Reference

DRAVP 2.0

Other

ctive against S. aureus (MIC 64 uM) and E. faecalis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (MIC >512 uM) and C.albicans (MIC >256 uM).
Evidence 16 Activity

Activity

MIC
Antiviral
>512 µM

Target

P.aeruginosa

Source & Reference

DRAVP 2.0

Other

us (MIC 64 uM) and E. faecalis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (MIC >512 uM) and C.albicans (MIC >256 uM).
Evidence 17 Activity

Activity

MIC
Antiviral
>512 µM

Target

K.pneumoniae

Source & Reference

DRAVP 2.0

Other

lis (MIC 64 uM). Inactive: MRSA-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (MIC >512 uM) and C.albicans (MIC >256 uM).
Evidence 18 Activity

Activity

MIC
Antiviral
>256 µM

Target

C.albicans

Source & Reference

DRAVP 2.0

Other

-inactive, E.coli (MIC>512 uM), P.aeruginosa (MIC>512 uM), K.pneumoniae (MIC >512 uM) and C.albicans (MIC >256 uM).
Evidence 19 Activity

Activity

55% Cytotoxicity
Toxicity
100 µM
Cytotoxic
55% Cytotoxicity | 100 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Brevinin-2GHk From Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity | Antibiotics (Basel) | 2020
Evidence 20 Activity

Activity

23% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
23% Hemolysis | 128 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Brevinin-2GHk From Sylvirana guentheri and the Design of Truncated Analogs Exhibiting the Enhancement of Antimicrobial Activity | Antibiotics (Basel) | 2020
Evidence 21 Activity

Activity

<10% Cytotoxicity
Toxicity
20 µM
Cytotoxic
<10% Cytotoxicity | 20 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Brevinin-2GHk, a Peptide Derived from the Skin of Fejervarya limnocharis, Inhibits Zika Virus Infection by Disrupting Viral Integrity | Viruses | 2021
Evidence 22 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.34960651]exhibited no significant toxicity to Vero, Hela, and Huh7 cells in the concentration range 0-20 µM.

Source & Reference

NA
DRAMP
Viruses. 2021 Nov 28 13(12):2382.