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Peptide record

TPDB13636

Antibacterial Hemolysis Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB13636
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
GLRRLLRKIRGRWKGGGRLLRPLLQLLKQKLR
Physicochemical Analysis
C174H315N63O35
ANDCEHMFSTYV
L
3849.82
13.25
12
0
12
+12
4.34
-0.644
134.06
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
142.86
2
Residue Composition
number
0
A
8
R
0
N
0
D
0
C
0
E
2
Q
5
G
0
H
1
I
10
L
4
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 5 H: 0 I: 1 L: 10 K: 4 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
32
C174H315N63O35
3849.82
13.25
+12
4.34
-0.644
Evidence Records 3 records
Evidence 1 Activity

Activity

18% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
18% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Enhancement of the antimicrobial activity and selectivity of GNU7 against Gram-negative bacteria by fusion with LPS-targeting peptide. | Peptides | 2016
Evidence 2 Activity

Activity

18% Killing
Toxicity
8 µM
Cytotoxic
18% Killing | 8 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Enhancement of the antimicrobial activity and selectivity of GNU7 against Gram-negative bacteria by fusion with LPS-targeting peptide. | Peptides | 2016
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis