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Peptide record

TPDB13635

Antibacterial Anticancer Antifungal Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13635
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
RRIPFWPIPLRWQWPPPWFPPSFPIPRISRKR
Physicochemical Analysis
C204H296N56O36
ANDCEGHMTYV
P
4108.95
13.10
7
0
12
+7
-1.40
-0.794
60.94
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
535.42
3
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
4
I
1
L
1
K
0
M
3
F
10
P
2
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 4 L: 1 K: 1 M: 0 F: 3 P: 10 S: 2 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
32
C204H296N56O36
4108.95
13.10
+7
-1.40
-0.794
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli ATCC 25922 (MIC 6 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM), K-pneumoniae ATCC 700
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

E. faecium ATCC 19434

Source & Reference

dbAMP

Other

active against E. coli ATCC 25922 (MIC 6 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM), K-pneumoniae ATCC 700603 (MIC >64 uM), A. baumannii ATC
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

active against E. coli ATCC 25922 (MIC 6 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM), K-pneumoniae ATCC 700603 (MIC >64 uM), A. baumannii ATCC 19606 (MIC 4 uM), P. aeruginosa
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP

Other

19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM), K-pneumoniae ATCC 700603 (MIC >64 uM), A. baumannii ATCC 19606 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), E. agglomerans clinical isolate (MIC 8 uM), S. mal
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

23 (MIC 8 uM), K-pneumoniae ATCC 700603 (MIC >64 uM), A. baumannii ATCC 19606 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), E. agglomerans clinical isolate (MIC 8 uM), S. maltophilia ATCC 13637 (MIC 4 uM), C. alb
Evidence 6 Activity

Activity

MIC
Antibacterial
8 µM

Target

E. agglomerans clinical isolate

Source & Reference

dbAMP

Other

3 (MIC >64 uM), A. baumannii ATCC 19606 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), E. agglomerans clinical isolate (MIC 8 uM), S. maltophilia ATCC 13637 (MIC 4 uM), C. albicans ATCC 90029 (MIC 8 uM),
Evidence 7 Activity

Activity

MIC
Antibacterial
4 µM

Target

Stenotrophomonas maltophilia ATCC 13637

Source & Reference

dbAMP

Other

4 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), E. agglomerans clinical isolate (MIC 8 uM), S. maltophilia ATCC 13637 (MIC 4 uM), C. albicans ATCC 90029 (MIC 8 uM),
Evidence 8 Activity

Activity

MIC
Antibacterial
8 µM

Target

Candida albicans ATCC 90029

Source & Reference

dbAMP

Other

16 uM), E. agglomerans clinical isolate (MIC 8 uM), S. maltophilia ATCC 13637 (MIC 4 uM), C. albicans ATCC 90029 (MIC 8 uM),
Evidence 9 Activity

Activity

MIC
Antifungal
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against E. coli ATCC 25922 (MIC 6 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM), K-pneumoniae ATCC 700
Evidence 10 Activity

Activity

MIC
Antifungal
4 µM

Target

E. faecium ATCC 19434

Source & Reference

dbAMP CAFPdb

Other

active against E. coli ATCC 25922 (MIC 6 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM), K-pneumoniae ATCC 700603 (MIC >64 uM), A. baumannii ATC
Evidence 11 Activity

Activity

MIC
Antifungal
8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb

Other

active against E. coli ATCC 25922 (MIC 6 uM), E. faecium ATCC 19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM), K-pneumoniae ATCC 700603 (MIC >64 uM), A. baumannii ATCC 19606 (MIC 4 uM), P. aeruginosa
Evidence 12 Activity

Activity

MIC
Antifungal
4 µM

Target

A. baumannii ATCC 19606

Source & Reference

dbAMP CAFPdb

Other

19434 (MIC 4 uM), S. aureus ATCC 25923 (MIC 8 uM), K-pneumoniae ATCC 700603 (MIC >64 uM), A. baumannii ATCC 19606 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), E. agglomerans clinical isolate (MIC 8 uM), S. mal
Evidence 13 Activity

Activity

MIC
Antifungal
16 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb

Other

23 (MIC 8 uM), K-pneumoniae ATCC 700603 (MIC >64 uM), A. baumannii ATCC 19606 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), E. agglomerans clinical isolate (MIC 8 uM), S. maltophilia ATCC 13637 (MIC 4 uM), C. alb
Evidence 14 Activity

Activity

MIC
Antifungal
8 µM

Target

E. agglomerans clinical isolate

Source & Reference

dbAMP CAFPdb

Other

3 (MIC >64 uM), A. baumannii ATCC 19606 (MIC 4 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), E. agglomerans clinical isolate (MIC 8 uM), S. maltophilia ATCC 13637 (MIC 4 uM), C. albicans ATCC 90029 (MIC 8 uM),
Evidence 15 Activity

Activity

MIC
Antifungal
4 µM

Target

Stenotrophomonas maltophilia ATCC 13637

Source & Reference

dbAMP CAFPdb

Other

4 uM), P. aeruginosa ATCC 27853 (MIC 16 uM), E. agglomerans clinical isolate (MIC 8 uM), S. maltophilia ATCC 13637 (MIC 4 uM), C. albicans ATCC 90029 (MIC 8 uM),
Evidence 16 Activity

Activity

MIC
Antifungal
8 µM

Target

Candida albicans ATCC 90029

Source & Reference

dbAMP CAFPdb

Other

16 uM), E. agglomerans clinical isolate (MIC 8 uM), S. maltophilia ATCC 13637 (MIC 4 uM), C. albicans ATCC 90029 (MIC 8 uM),
Evidence 17 Activity

Activity

25% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
25% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020
Evidence 18 Activity

Activity

10% Killing
Toxicity
32 µM
Cytotoxic
10% Killing | 32 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020
Evidence 19 Activity

Activity

% Hemolysis
Toxicity
25 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:25% Hemolysis=32µM | Cytotoxicity: HaCat: 10% Killing=32µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2020 Oct 6 21(19):7367.