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Peptide record

TPDB13629

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard

32 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB13629

Activity

Antibacterial Anticancer Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis

Sequence_Type

standard

Has_Modification No

Description A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

AGGKRIVKRIKKFLRGAGGKRIVKRIKKFLRG

FASTA

>TPDB13629|Antibacterial;Anticancer;Antifungal;Hemolysis;Toxicity|length=32
AGGKRIVKRIKKFLRGAGGKRIVKRIKKFLRG

Formula C166H300N58O33

Absent Amino Acids NDCEQHMPSTWY

Common Amino Acids K

Mass 3636.58

PI 13.11

Basic Residues 14

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +14

Boman Index 8.02

Hydrophobicity -0.544

Aliphatic Index 97.50

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 2 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 6 H: 0 I: 4 L: 2 K: 8 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

Formula

C166H300N58O33

Mass

3636.58

13.11

Net Charge

+14

Boman Index

8.02

Hydrophobicity

-0.544

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.625 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against E. coli (MIC 0.625 uM), P. aeruginosa (MIC 0.625 uM), S. aureus (MIC 0.625 uM), and C. albicans (MIC 1.25 uM). W

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.625 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against E. coli (MIC 0.625 uM), P. aeruginosa (MIC 0.625 uM), S. aureus (MIC 0.625 uM), and C. albicans (MIC 1.25 uM). Warning: Nonstandard assays.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.625 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against E. coli (MIC 0.625 uM), P. aeruginosa (MIC 0.625 uM), S. aureus (MIC 0.625 uM), and C. albicans (MIC 1.25 uM). Warning: Nonstandard assays.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

ainst E. coli (MIC 0.625 uM), P. aeruginosa (MIC 0.625 uM), S. aureus (MIC 0.625 uM), and C. albicans (MIC 1.25 uM). Warning: Nonstandard assays.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.625 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against E. coli (MIC 0.625 uM), P. aeruginosa (MIC 0.625 uM), S. aureus (MIC 0.625 uM), and C. albicans (MIC 1.25 uM). W

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.625 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 0.625 uM), P. aeruginosa (MIC 0.625 uM), S. aureus (MIC 0.625 uM), and C. albicans (MIC 1.25 uM). Warning: Nonstandard assays.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.625 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against E. coli (MIC 0.625 uM), P. aeruginosa (MIC 0.625 uM), S. aureus (MIC 0.625 uM), and C. albicans (MIC 1.25 uM). Warning: Nonstandard assays.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.25 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ainst E. coli (MIC 0.625 uM), P. aeruginosa (MIC 0.625 uM), S. aureus (MIC 0.625 uM), and C. albicans (MIC 1.25 uM). Warning: Nonstandard assays.

Evidence 9 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability. | Front Microbiol | 2020

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Front Microbiol. 2020 Feb 21 11:169.

Evidence 11 Hemolysis

Source & Reference

source PD_Hemolysis

Database Source PD_Hemolysis