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Peptide record

TPDB13622

Antibacterial Anticancer Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB13622
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RRIPFWPPNLPGPRRPPWFLPDFRIPRIPRKR
Physicochemical Analysis
C193H296N60O36
ACEQHMSTYV
P
4032.85
12.88
9
1
10
+8
4.49
-1.113
60.94
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
272.76
1
Residue Composition
number
0
A
8
R
1
N
1
D
0
C
0
E
0
Q
1
G
0
H
3
I
2
L
1
K
0
M
3
F
10
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 1 M: 0 F: 3 P: 10 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
32
C193H296N60O36
4032.85
12.88
+8
4.49
-1.113
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 6 uM), E. faecium ATCC 19434 (MIC 16 uM), S. aureus ATCC 25923 (MIC 32 uM), K. pneumoniae ATCC
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

E. faecium ATCC 19434

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 6 uM), E. faecium ATCC 19434 (MIC 16 uM), S. aureus ATCC 25923 (MIC 32 uM), K. pneumoniae ATCC 700603 (MIC 32 uM), A. baumannii AT
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 6 uM), E. faecium ATCC 19434 (MIC 16 uM), S. aureus ATCC 25923 (MIC 32 uM), K. pneumoniae ATCC 700603 (MIC 32 uM), A. baumannii ATCC 19606 (MIC 2 uM), P. aeruginosa
Evidence 4 Activity

Activity

MIC
Antibacterial
32 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

NA

Other

CC 25922 (MIC 6 uM), E. faecium ATCC 19434 (MIC 16 uM), S. aureus ATCC 25923 (MIC 32 uM), K. pneumoniae ATCC 700603 (MIC 32 uM), A. baumannii ATCC 19606 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 32 uM), E. agglomerans
Evidence 5 Activity

Activity

MIC
Antibacterial
2 µM

Target

A. baumannii ATCC 19606

Source & Reference

NA

Other

434 (MIC 16 uM), S. aureus ATCC 25923 (MIC 32 uM), K. pneumoniae ATCC 700603 (MIC 32 uM), A. baumannii ATCC 19606 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 32 uM), E. agglomerans clinical isolate (MIC 8 uM), S. mal
Evidence 6 Activity

Activity

MIC
Antibacterial
32 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

3 (MIC 32 uM), K. pneumoniae ATCC 700603 (MIC 32 uM), A. baumannii ATCC 19606 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 32 uM), E. agglomerans clinical isolate (MIC 8 uM), S. maltophilia ATCC 13637 (MIC 2 uM), C. alb
Evidence 7 Activity

Activity

MIC
Antibacterial
8 µM

Target

E. agglomerans clinical isolate

Source & Reference

NA

Other

03 (MIC 32 uM), A. baumannii ATCC 19606 (MIC 2 uM), P. aeruginosa ATCC 27853 (MIC 32 uM), E. agglomerans clinical isolate (MIC 8 uM), S. maltophilia ATCC 13637 (MIC 2 uM), C. albicans ATCC 90029 (MIC 4 uM),
Evidence 8 Activity

Activity

MIC
Antibacterial
2 µM

Target

Stenotrophomonas maltophilia ATCC 13637

Source & Reference

NA

Other

2 uM), P. aeruginosa ATCC 27853 (MIC 32 uM), E. agglomerans clinical isolate (MIC 8 uM), S. maltophilia ATCC 13637 (MIC 2 uM), C. albicans ATCC 90029 (MIC 4 uM),
Evidence 9 Activity

Activity

MIC
Antibacterial
4 µM

Target

Candida albicans ATCC 90029

Source & Reference

NA

Other

32 uM), E. agglomerans clinical isolate (MIC 8 uM), S. maltophilia ATCC 13637 (MIC 2 uM), C. albicans ATCC 90029 (MIC 4 uM),
Evidence 10 Activity

Activity

0% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
0% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020
Evidence 11 Activity

Activity

15% Killing
Toxicity
32 µM
Cytotoxic
15% Killing | 32 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020
Evidence 12 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:0% Hemolysis=32µM | Cytotoxicity: HaCat: 15% Killing=32µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2020 Oct 6 21(19):7367.