Back to search

Peptide record

TPDB13621

Antibacterial Anticancer Antifungal Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13621
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
VKRTKRGARRGLTKVLKKIFGSIVKKAVSKGV
Physicochemical Analysis
C158H290N52O37
NDCEQHMPWY
K
3510.37
12.90
12
0
12
+12
8.88
-0.306
100.31
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
2
A
4
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
2
I
2
L
8
K
0
M
1
F
0
P
2
S
2
T
0
W
0
Y
5
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 2 L: 2 K: 8 M: 0 F: 1 P: 0 S: 2 T: 2 W: 0 Y: 0 V: 5
Chemical Descriptors
32
C158H290N52O37
3510.37
12.90
+12
8.88
-0.306
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.85 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

NA

Other

MIC assays using gram-positive strains, S. aureus ATCC 6538 (MIC 0.85 uM), Bacillus cereus ATCC 10876 (MIC 8.5 uM), and E. faecalis ATCC 29212 (MIC 0.57 uM), and 3
Evidence 2 Activity

Activity

MIC
Antibacterial
0.57 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

NA

Other

strains, S. aureus ATCC 6538 (MIC 0.85 uM), Bacillus cereus ATCC 10876 (MIC 8.5 uM), and E. faecalis ATCC 29212 (MIC 0.57 uM), and 3 gram-negative strains, E. coli ATCC 25922 (MIC 0.21 uM), P. aeruginosa ATCC 27853
Evidence 3 Activity

Activity

MIC
Antibacterial
0.21 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

0876 (MIC 8.5 uM), and E. faecalis ATCC 29212 (MIC 0.57 uM), and 3 gram-negative strains, E. coli ATCC 25922 (MIC 0.21 uM), P. aeruginosa ATCC 27853 (MIC 0.57 uM), and S. typhimurium ATCC 14028 (MIC 0.57 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
0.57 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

ATCC 29212 (MIC 0.57 uM), and 3 gram-negative strains, E. coli ATCC 25922 (MIC 0.21 uM), P. aeruginosa ATCC 27853 (MIC 0.57 uM), and S. typhimurium ATCC 14028 (MIC 0.57 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
0.57 µM

Target

S. typhimurium ATCC 14028

Source & Reference

NA

Other

ve strains, E. coli ATCC 25922 (MIC 0.21 uM), P. aeruginosa ATCC 27853 (MIC 0.57 uM), and S. typhimurium ATCC 14028 (MIC 0.57 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
0.85 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

Antifungipept

Other

MIC assays using gram-positive strains, S. aureus ATCC 6538 (MIC 0.85 uM), Bacillus cereus ATCC 10876 (MIC 8.5 uM), and E. faecalis ATCC 29212 (MIC 0.57 uM), and 3
Evidence 7 Activity

Activity

MIC
Antifungal
0.57 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

Antifungipept

Other

strains, S. aureus ATCC 6538 (MIC 0.85 uM), Bacillus cereus ATCC 10876 (MIC 8.5 uM), and E. faecalis ATCC 29212 (MIC 0.57 uM), and 3 gram-negative strains, E. coli ATCC 25922 (MIC 0.21 uM), P. aeruginosa ATCC 27853
Evidence 8 Activity

Activity

MIC
Antifungal
0.21 µM

Target

Escherichia coli ATCC 25922

Source & Reference

Antifungipept

Other

0876 (MIC 8.5 uM), and E. faecalis ATCC 29212 (MIC 0.57 uM), and 3 gram-negative strains, E. coli ATCC 25922 (MIC 0.21 uM), P. aeruginosa ATCC 27853 (MIC 0.57 uM), and S. typhimurium ATCC 14028 (MIC 0.57 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
0.57 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

Antifungipept

Other

ATCC 29212 (MIC 0.57 uM), and 3 gram-negative strains, E. coli ATCC 25922 (MIC 0.21 uM), P. aeruginosa ATCC 27853 (MIC 0.57 uM), and S. typhimurium ATCC 14028 (MIC 0.57 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
0.57 µM

Target

S. typhimurium ATCC 14028

Source & Reference

Antifungipept

Other

ve strains, E. coli ATCC 25922 (MIC 0.21 uM), P. aeruginosa ATCC 27853 (MIC 0.57 uM), and S. typhimurium ATCC 14028 (MIC 0.57 uM).
Evidence 11 Activity

Activity

0% Cytotoxicity
Toxicity
16 µg/mL
Cytotoxic
0% Cytotoxicity | 16 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 12 Activity

Activity

33% Cytotoxicity
Toxicity
32 µg/mL
Cytotoxic
33% Cytotoxicity | 32 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 13 Activity

Activity

44.3% Cytotoxicity
Toxicity
64 µg/mL
Cytotoxic
44.3% Cytotoxicity | 64 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 14 Activity

Activity

8.6% Cytotoxicity
Toxicity
16 µg/mL
Cytotoxic
8.6% Cytotoxicity | 16 | µg/mL | target cell: Human Primary Epidermal Keratinocytes (HEK)

Target

Human Primary Epidermal Keratinocytes (HEK)

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 15 Activity

Activity

43.8% Cytotoxicity
Toxicity
32 µg/mL
Cytotoxic
43.8% Cytotoxicity | 32 | µg/mL | target cell: Human Primary Epidermal Keratinocytes (HEK)

Target

Human Primary Epidermal Keratinocytes (HEK)

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 16 Activity

Activity

94.2% Cytotoxicity
Toxicity
64 µg/mL
Cytotoxic
94.2% Cytotoxicity | 64 | µg/mL | target cell: Human Primary Epidermal Keratinocytes (HEK)

Target

Human Primary Epidermal Keratinocytes (HEK)

Source & Reference

NA
DBAASP
Opossum Cathelicidins Exhibit Antimicrobial Activity Against a Broad Spectrum of Pathogens Including West Nile Virus | Front Immunol | 2020
Evidence 17 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Immunol. 2020 Mar 3 11:347.