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Peptide record

TPDB13614

Antibacterial Antifungal Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB13614
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 32-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
KKCWNGGRCRKKCKENEKPIGYCRNGKKCCVN
Physicochemical Analysis
C154H260N54O42S6
ADQHLMFST
K
3732.46
10.01
11
2
4
+9
12.09
-1.481
21.25
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
7365
197.32
11
Residue Composition
number
0
A
3
R
4
N
0
D
6
C
2
E
0
Q
4
G
0
H
1
I
0
L
8
K
0
M
0
F
1
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 4 D: 0 C: 6 E: 2 Q: 0 G: 4 H: 0 I: 1 L: 0 K: 8 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
32
C154H260N54O42S6
3732.46
10.01
+9
12.09
-1.481
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

NA

Other

Active against S. aureus ATCC25923 (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), and M. tuberculosis H37Rv or MDR (MIC 8.8-25.9 uM) (anti-
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli ATCC25922

Source & Reference

NA

Other

Active against S. aureus ATCC25923 (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), and M. tuberculosis H37Rv or MDR (MIC 8.8-25.9 uM) (anti-TB). In culture broth, it only
Evidence 3 Activity

Activity

MIC
Antibacterial
8.8-25.9 µM

Target

M. tuberculosis H37Rv or MDR

Source & Reference

NA

Other

Active against S. aureus ATCC25923 (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), and M. tuberculosis H37Rv or MDR (MIC 8.8-25.9 uM) (anti-TB). In culture broth, it only showed a bacteriostatic effect.
Evidence 4 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

Antifungipept

Other

Active against S. aureus ATCC25923 (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), and M. tuberculosis H37Rv or MDR (MIC 8.8-25.9 uM) (anti-
Evidence 5 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli ATCC25922

Source & Reference

Antifungipept

Other

Active against S. aureus ATCC25923 (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), and M. tuberculosis H37Rv or MDR (MIC 8.8-25.9 uM) (anti-TB). In culture broth, it only
Evidence 6 Activity

Activity

MIC
Antifungal
8.8-25.9 µM

Target

M. tuberculosis H37Rv or MDR

Source & Reference

Antifungipept

Other

Active against S. aureus ATCC25923 (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), and M. tuberculosis H37Rv or MDR (MIC 8.8-25.9 uM) (anti-TB). In culture broth, it only showed a bacteriostatic effect.
Evidence 7 Activity

Activity

1.6% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
1.6% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity and structure of a consensus human ?-defensin and its comparison to a novel putative hBD10. | Proteins | 2019