TPDB

3D PDB MODEL

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TPDB ID TPDB13611

Activity

Antibacterial Anticancer Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.

Sequence

RRIRFPFPPFPWQWPPAGFPTFHIPRIPRKQ

FASTA

>TPDB13611|Antibacterial;Anticancer;Antifungal;Toxicity|length=31
RRIRFPFPPFPWQWPPAGFPTFHIPRIPRKQ

Formula C191H273N53O35

Absent Amino Acids NDCELMSYV

Common Amino Acids P

Mass 3871.60

PI 13.00

Basic Residues 7

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +6

Boman Index 0.91

Hydrophobicity -0.794

Aliphatic Index 40.97

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 284.12

Polar Residues 3

number

1

A

5

R

0

N

0

D

0

C

0

E

2

Q

1

G

1

H

3

I

0

L

1

K

0

M

5

F

9

P

0

S

1

T

2

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 1 I: 3 L: 0 K: 1 M: 0 F: 5 P: 9 S: 0 T: 1 W: 2 Y: 0 V: 0

Length

31

Formula

C191H273N53O35

Mass

3871.60

PI

13.00

Net Charge

+6

Boman Index

0.91

Hydrophobicity

-0.794

Evidence 1 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 32 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020

Evidence 2 Activity

Activity

Activity Endpoint 12% Killing

Detail Source Activity Toxicity

Activity Measurement 32 µM

Toxicity Type Cytotoxic

Toxicity Raw

12% Killing | 32 | µM | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020

Evidence 3 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Toxicity

Activity Measurement 0 %

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Human erythrocytes:0% Hemolysis=32µM | Cytotoxicity: HaCat: 12% Killing=32µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Int J Mol Sci. 2020 Oct 6 21(19):7367.