Back to search

Peptide record

TPDB13611

Antibacterial Anticancer Antifungal Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB13611
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 31-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
RRIRFPFPPFPWQWPPAGFPTFHIPRIPRKQ
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C191H273N53O35
NDCELMSYV
P
3871.60
13.00
7
0
11
+6
1.98
-0.794
40.97
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
2.84
3
Residue Composition
number
1
A
5
R
0
N
0
D
0
C
0
E
2
Q
1
G
1
H
3
I
0
L
1
K
0
M
5
F
9
P
0
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 1 I: 3 L: 0 K: 1 M: 0 F: 5 P: 9 S: 0 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
31 reviewed residue count
C191H273N53O35 sequence-only estimate (linear, free termini)
3871.60 sequence-only estimate (linear, free termini)
13.00 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
1.98 sequence-only estimate (linear, free termini)
-0.794 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
0% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020
Evidence 2 Activity

Activity

12% Killing
Toxicity
32 µM
Cytotoxic
12% Killing | 32 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Characterization of Cetacean Proline-Rich Antimicrobial Peptides Displaying Activity against ESKAPE Pathogens. | Int J Mol Sci | 2020
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:0% Hemolysis=32µM | Cytotoxicity: HaCat: 12% Killing=32µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2020 Oct 6 21(19):7367.