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Peptide record

TPDB13598

Anti-inflammatory Antibacterial Antifungal Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB13598
Anti-inflammatory Antibacterial Antifungal Toxicity
Anti-infective peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia AntiBP3 Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiBP3, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KFFKKLKKSVKKHVKKFFKKPKVIGVSIPF
Physicochemical Analysis
C179H294N44O33
ARNDCEQMTWY
K
3590.58
11.55
13
0
12
+12
7.46
-0.387
77.67
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
2
I
1
L
12
K
0
M
5
F
2
P
2
S
0
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 2 L: 1 K: 12 M: 0 F: 5 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 4
Chemical Descriptors
30
C179H294N44O33
3590.58
11.55
+12
7.46
-0.387
Evidence Records 25 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5.22-20.88 µM

Target

Escherichia coli ATCC25922 or clinical strain

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli ATCC25922 or clinical strain (MIC 5.22-20.88 uM), S. dysenteriae clinical strain (MIC 10.44 uM), K. peneumoniae clinical strain (MIC 10.44
Evidence 2 Activity

Activity

MIC
Antibacterial
10.44 µM

Target

S. dysenteriae clinical strain

Source & Reference

dbAMP

Other

Active against Gram- E. coli ATCC25922 or clinical strain (MIC 5.22-20.88 uM), S. dysenteriae clinical strain (MIC 10.44 uM), K. peneumoniae clinical strain (MIC 10.44 uM), P. aeruginosa ATCC27853 (MIC 10.44 uM), G
Evidence 3 Activity

Activity

MIC
Antibacterial
10.44 µM

Target

K. peneumoniae clinical strain

Source & Reference

dbAMP

Other

22 or clinical strain (MIC 5.22-20.88 uM), S. dysenteriae clinical strain (MIC 10.44 uM), K. peneumoniae clinical strain (MIC 10.44 uM), P. aeruginosa ATCC27853 (MIC 10.44 uM), Gram+ S. aureus ATCC25923 (MIC 20.88 uM), B. cer
Evidence 4 Activity

Activity

MIC
Antibacterial
10.44 µM

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP

Other

ysenteriae clinical strain (MIC 10.44 uM), K. peneumoniae clinical strain (MIC 10.44 uM), P. aeruginosa ATCC27853 (MIC 10.44 uM), Gram+ S. aureus ATCC25923 (MIC 20.88 uM), B. cereus clinical strain (MIC 1.3 uM), B. sub
Evidence 5 Activity

Activity

MIC
Antibacterial
20.88 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP

Other

peneumoniae clinical strain (MIC 10.44 uM), P. aeruginosa ATCC27853 (MIC 10.44 uM), Gram+ S. aureus ATCC25923 (MIC 20.88 uM), B. cereus clinical strain (MIC 1.3 uM), B. subtilis clinical strain (MIC 5.22 uM), E. fa
Evidence 6 Activity

Activity

MIC
Antibacterial
1.3 µM

Target

B. cereus clinical strain

Source & Reference

dbAMP

Other

44 uM), P. aeruginosa ATCC27853 (MIC 10.44 uM), Gram+ S. aureus ATCC25923 (MIC 20.88 uM), B. cereus clinical strain (MIC 1.3 uM), B. subtilis clinical strain (MIC 5.22 uM), E. faecium clinical strain (MIC 10.44 uM), N.
Evidence 7 Activity

Activity

MIC
Antibacterial
5.22 µM

Target

B. subtilis clinical strain

Source & Reference

dbAMP

Other

44 uM), Gram+ S. aureus ATCC25923 (MIC 20.88 uM), B. cereus clinical strain (MIC 1.3 uM), B. subtilis clinical strain (MIC 5.22 uM), E. faecium clinical strain (MIC 10.44 uM), N. asteroides clinical strain (MIC 10.4 uM),
Evidence 8 Activity

Activity

MIC
Antibacterial
10.44 µM

Target

E. faecium clinical strain

Source & Reference

dbAMP

Other

8 uM), B. cereus clinical strain (MIC 1.3 uM), B. subtilis clinical strain (MIC 5.22 uM), E. faecium clinical strain (MIC 10.44 uM), N. asteroides clinical strain (MIC 10.4 uM), fungi C. albicans (MIC 5.22-10.44 uM) and C
Evidence 9 Activity

Activity

MIC
Antibacterial
10.4 µM

Target

N. asteroides clinical strain

Source & Reference

dbAMP

Other

M), B. subtilis clinical strain (MIC 5.22 uM), E. faecium clinical strain (MIC 10.44 uM), N. asteroides clinical strain (MIC 10.4 uM), fungi C. albicans (MIC 5.22-10.44 uM) and C. glabrata clinical strains (MIC 10.4 uM). In
Evidence 10 Activity

Activity

MIC
Antibacterial
5.22-10.44 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

aecium clinical strain (MIC 10.44 uM), N. asteroides clinical strain (MIC 10.4 uM), fungi C. albicans (MIC 5.22-10.44 uM) and C. glabrata clinical strains (MIC 10.4 uM). In addition, SA-CATH showed a dose-depend
Evidence 11 Activity

Activity

MIC
Antibacterial
10.4 µM

Target

C. glabrata clinical strains

Source & Reference

dbAMP

Other

), N. asteroides clinical strain (MIC 10.4 uM), fungi C. albicans (MIC 5.22-10.44 uM) and C. glabrata clinical strains (MIC 10.4 uM). In addition, SA-CATH showed a dose-dependent inhibitory effect on the biofilm formation
Evidence 12 Activity

Activity

MIC
Antifungal
5.22-20.88 µM

Target

Escherichia coli ATCC25922 or clinical strain

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli ATCC25922 or clinical strain (MIC 5.22-20.88 uM), S. dysenteriae clinical strain (MIC 10.44 uM), K. peneumoniae clinical strain (MIC 10.44
Evidence 13 Activity

Activity

MIC
Antifungal
10.44 µM

Target

S. dysenteriae clinical strain

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli ATCC25922 or clinical strain (MIC 5.22-20.88 uM), S. dysenteriae clinical strain (MIC 10.44 uM), K. peneumoniae clinical strain (MIC 10.44 uM), P. aeruginosa ATCC27853 (MIC 10.44 uM), G
Evidence 14 Activity

Activity

MIC
Antifungal
10.44 µM

Target

K. peneumoniae clinical strain

Source & Reference

dbAMP CAFPdb Antifungipept

Other

22 or clinical strain (MIC 5.22-20.88 uM), S. dysenteriae clinical strain (MIC 10.44 uM), K. peneumoniae clinical strain (MIC 10.44 uM), P. aeruginosa ATCC27853 (MIC 10.44 uM), Gram+ S. aureus ATCC25923 (MIC 20.88 uM), B. cer
Evidence 15 Activity

Activity

MIC
Antifungal
10.44 µM

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ysenteriae clinical strain (MIC 10.44 uM), K. peneumoniae clinical strain (MIC 10.44 uM), P. aeruginosa ATCC27853 (MIC 10.44 uM), Gram+ S. aureus ATCC25923 (MIC 20.88 uM), B. cereus clinical strain (MIC 1.3 uM), B. sub
Evidence 16 Activity

Activity

MIC
Antifungal
20.88 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

peneumoniae clinical strain (MIC 10.44 uM), P. aeruginosa ATCC27853 (MIC 10.44 uM), Gram+ S. aureus ATCC25923 (MIC 20.88 uM), B. cereus clinical strain (MIC 1.3 uM), B. subtilis clinical strain (MIC 5.22 uM), E. fa
Evidence 17 Activity

Activity

MIC
Antifungal
1.3 µM

Target

B. cereus clinical strain

Source & Reference

dbAMP CAFPdb Antifungipept

Other

44 uM), P. aeruginosa ATCC27853 (MIC 10.44 uM), Gram+ S. aureus ATCC25923 (MIC 20.88 uM), B. cereus clinical strain (MIC 1.3 uM), B. subtilis clinical strain (MIC 5.22 uM), E. faecium clinical strain (MIC 10.44 uM), N.
Evidence 18 Activity

Activity

MIC
Antifungal
5.22 µM

Target

B. subtilis clinical strain

Source & Reference

dbAMP CAFPdb Antifungipept

Other

44 uM), Gram+ S. aureus ATCC25923 (MIC 20.88 uM), B. cereus clinical strain (MIC 1.3 uM), B. subtilis clinical strain (MIC 5.22 uM), E. faecium clinical strain (MIC 10.44 uM), N. asteroides clinical strain (MIC 10.4 uM),
Evidence 19 Activity

Activity

MIC
Antifungal
10.44 µM

Target

E. faecium clinical strain

Source & Reference

dbAMP CAFPdb Antifungipept

Other

8 uM), B. cereus clinical strain (MIC 1.3 uM), B. subtilis clinical strain (MIC 5.22 uM), E. faecium clinical strain (MIC 10.44 uM), N. asteroides clinical strain (MIC 10.4 uM), fungi C. albicans (MIC 5.22-10.44 uM) and C
Evidence 20 Activity

Activity

MIC
Antifungal
10.4 µM

Target

N. asteroides clinical strain

Source & Reference

dbAMP CAFPdb Antifungipept

Other

M), B. subtilis clinical strain (MIC 5.22 uM), E. faecium clinical strain (MIC 10.44 uM), N. asteroides clinical strain (MIC 10.4 uM), fungi C. albicans (MIC 5.22-10.44 uM) and C. glabrata clinical strains (MIC 10.4 uM). In
Evidence 21 Activity

Activity

MIC
Antifungal
5.22-10.44 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

aecium clinical strain (MIC 10.44 uM), N. asteroides clinical strain (MIC 10.4 uM), fungi C. albicans (MIC 5.22-10.44 uM) and C. glabrata clinical strains (MIC 10.4 uM). In addition, SA-CATH showed a dose-depend
Evidence 22 Activity

Activity

MIC
Antifungal
10.4 µM

Target

C. glabrata clinical strains

Source & Reference

dbAMP CAFPdb Antifungipept

Other

), N. asteroides clinical strain (MIC 10.4 uM), fungi C. albicans (MIC 5.22-10.44 uM) and C. glabrata clinical strains (MIC 10.4 uM). In addition, SA-CATH showed a dose-dependent inhibitory effect on the biofilm formation
Evidence 23 Activity

Activity

3.45% Killing
Toxicity
200 µg/mL
Cytotoxic
3.45% Killing | 200 | µg/mL | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
Characterization of a Cathelicidin from the Colubrinae Snake, Sinonatrix annularis. | Zoolog Sci | 2019
Evidence 24 Activity

Activity

4.76% Killing
Toxicity
200 µg/mL
Cytotoxic
4.76% Killing | 200 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Characterization of a Cathelicidin from the Colubrinae Snake, Sinonatrix annularis. | Zoolog Sci | 2019
Evidence 25 Activity

Activity

5.12% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
5.12% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of a Cathelicidin from the Colubrinae Snake, Sinonatrix annularis. | Zoolog Sci | 2019