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Peptide record

TPDB13591

Antibacterial Antifungal Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB13591
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
SQRKLAAKLTSKGGGRLLRPLLQLLKQKLR
Physicochemical Analysis
C150H276N50O37
NDCEHIMFWYV
L
3372.15
12.89
9
0
11
+9
5.43
-0.510
123.67
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
6
Residue Composition
number
2
A
4
R
0
N
0
D
0
C
0
E
3
Q
3
G
0
H
0
I
9
L
5
K
0
M
0
F
1
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 3 G: 3 H: 0 I: 0 L: 9 K: 5 M: 0 F: 0 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
30
C150H276N50O37
3372.15
12.89
+9
5.43
-0.510
Evidence Records 2 records
Evidence 1 Activity

Activity

2% Hemolysis
Toxicity
65 µM
Hemolytic Cytotoxic
2% Hemolysis | 65 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Development of a Novel Hybrid Antimicrobial Peptide for Targeted Killing of Pseudomonas Aeruginosa. | Eur J Med Chem | 2020
Evidence 2 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.31678742]PA2-GNU7 was not toxic to human RBCs at the tested concentrations (0 - 65 µM).The haemolysis was less than 2.5 % up to the concentration of 65 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Med Chem. 2020 Jan 1 185:111814. doi: 10.1016/j.ejmech.2019.111814. Epub 2019 Oct 25.